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The map label for this gene is dxr1 [H]

Identifier: 188586061

GI number: 188586061

Start: 1501107

End: 1502267

Strand: Direct

Name: dxr1 [H]

Synonym: Nther_1435

Alternate gene names: 188586061

Gene position: 1501107-1502267 (Clockwise)

Preceding gene: 188586060

Following gene: 188586062

Centisome position: 47.42

GC content: 34.71

Gene sequence:

>1161_bases
ATGTTTGAAAAAAATATTAGTATTTTAGGATCTACTGGCTCTATTGGAACACAAACTTTGGAAATAGTGGAGAATAATCC
TGATAAATACAATGTAGTAGCTTTGACTACTAATTCTAATATTGATACTCTAATTAATCAAGCTAAAAAATTTCACCCAA
ATTTATTGGTAGTTAATGATAGTTCTTTGAAAGATGAATTATGGAATAAACTTAAGGAAGAAAATTTAAACAATATAAAA
ATCGCTTCTGGACAGGAAGGTATGATCCAAGCTGGAGAAATGGCAGAGGCTGAATTAGTAGTTGTTTCTGTAGTAGGTTT
TAGTGGTGTAATCCCCACAATATCTGCATTGAAGGCCGATAAAGATGTTGCTTTGGCGAATAAAGAGACCCTTGTAGCTG
CCGGAGAACAGGTGATGCGATTAAGCCACCAATCAAAAGGACGCTTACTTCCAATAGACAGTGAACACTCGGCTATATTT
CAAGCTCTTATGGGTGAAAAAAATGATTCTGTAAATAAATTGATTTTAACAGCTTCAGGGGGACCTTTTTTCGGTAAAAC
AAAAGAAGAATTATATAACATTTCTCCTAAAGACGCTTTAAAGCACCCTAATTGGGATATGGGGAACAAAATAAGTATAG
ACTCAGCAACTTTAATGAACAAAGGATTGGAAGTGATAGAAGCTCACTGGTTATTTAATATACCTTTTGAACAAATAGAT
GTTGTGATTCACCCCCAGTCTATAGTTCATTCCTTAGTTGAGTTTGTGGACGGTGCAATGAAGGCAGAATTGGGATTACC
CGATATGAGAATTCCGATACAATTCGCTCTCGGATATCCTCAAAGGGAAGCCAATAATTTTGAACGATTAGATCTAACGG
ATTTTGATTTGACATTTAAAAAACCTGATACTAAAACATTTCCCTGTTTATCACTGGCTTATCAGGCTGGAAAAATTGGA
GGATCTATGCCTTGTGTTTTAAACGCAGCTAACGAGCAGGCAGTTTATCAATTTTTAGCTAAAAAGATCACTTTTTTACA
AATCCCGGAATTAATTGAAAAGGTTATGGAGAAACATGAGGTAATAAAGAATCCTTCCATTGAGAACTTAATCTCAGTAG
ATAATTGGGCAAGAAAAGCTACTGATGAAAATATAACTTAG

Upstream 100 bases:

>100_bases
CAGTTATCAACATTCAACTTTAATATAGCATATATCTAAACAAATATAATTAATAGTTTATGTTAACAATACGGAAAATA
ACTGTTATGGAGGCTTCCAA

Downstream 100 bases:

>100_bases
TTAAAAAGGGTGTATATTTATGGAAACATTGATTTATTCCATTATAATTTTTGGTTTATTGATATTCATGCATGAATTTG
GTCATTTTATCATAGCAAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 1; 1-deoxyxylulose-5-phosphate reductoisomerase 1; 2-C-methyl-D-erythritol 4-phosphate synthase 1 [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MFEKNISILGSTGSIGTQTLEIVENNPDKYNVVALTTNSNIDTLINQAKKFHPNLLVVNDSSLKDELWNKLKEENLNNIK
IASGQEGMIQAGEMAEAELVVVSVVGFSGVIPTISALKADKDVALANKETLVAAGEQVMRLSHQSKGRLLPIDSEHSAIF
QALMGEKNDSVNKLILTASGGPFFGKTKEELYNISPKDALKHPNWDMGNKISIDSATLMNKGLEVIEAHWLFNIPFEQID
VVIHPQSIVHSLVEFVDGAMKAELGLPDMRIPIQFALGYPQREANNFERLDLTDFDLTFKKPDTKTFPCLSLAYQAGKIG
GSMPCVLNAANEQAVYQFLAKKITFLQIPELIEKVMEKHEVIKNPSIENLISVDNWARKATDENIT

Sequences:

>Translated_386_residues
MFEKNISILGSTGSIGTQTLEIVENNPDKYNVVALTTNSNIDTLINQAKKFHPNLLVVNDSSLKDELWNKLKEENLNNIK
IASGQEGMIQAGEMAEAELVVVSVVGFSGVIPTISALKADKDVALANKETLVAAGEQVMRLSHQSKGRLLPIDSEHSAIF
QALMGEKNDSVNKLILTASGGPFFGKTKEELYNISPKDALKHPNWDMGNKISIDSATLMNKGLEVIEAHWLFNIPFEQID
VVIHPQSIVHSLVEFVDGAMKAELGLPDMRIPIQFALGYPQREANNFERLDLTDFDLTFKKPDTKTFPCLSLAYQAGKIG
GSMPCVLNAANEQAVYQFLAKKITFLQIPELIEKVMEKHEVIKNPSIENLISVDNWARKATDENIT
>Mature_386_residues
MFEKNISILGSTGSIGTQTLEIVENNPDKYNVVALTTNSNIDTLINQAKKFHPNLLVVNDSSLKDELWNKLKEENLNNIK
IASGQEGMIQAGEMAEAELVVVSVVGFSGVIPTISALKADKDVALANKETLVAAGEQVMRLSHQSKGRLLPIDSEHSAIF
QALMGEKNDSVNKLILTASGGPFFGKTKEELYNISPKDALKHPNWDMGNKISIDSATLMNKGLEVIEAHWLFNIPFEQID
VVIHPQSIVHSLVEFVDGAMKAELGLPDMRIPIQFALGYPQREANNFERLDLTDFDLTFKKPDTKTFPCLSLAYQAGKIG
GSMPCVLNAANEQAVYQFLAKKITFLQIPELIEKVMEKHEVIKNPSIENLISVDNWARKATDENIT

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=41.1167512690355, Blast_Score=305, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42644; Mature: 42644

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKNISILGSTGSIGTQTLEIVENNPDKYNVVALTTNSNIDTLINQAKKFHPNLLVVND
CCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEC
SSLKDELWNKLKEENLNNIKIASGQEGMIQAGEMAEAELVVVSVVGFSGVIPTISALKAD
CHHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCCCCEEEEEEECCCCCHHHHHHHHCCC
KDVALANKETLVAAGEQVMRLSHQSKGRLLPIDSEHSAIFQALMGEKNDSVNKLILTASG
CCEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEEEECC
GPFFGKTKEELYNISPKDALKHPNWDMGNKISIDSATLMNKGLEVIEAHWLFNIPFEQID
CCCCCCCHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHCCHHHEEEEEEEECCHHHEE
VVIHPQSIVHSLVEFVDGAMKAELGLPDMRIPIQFALGYPQREANNFERLDLTDFDLTFK
EEECCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEEECCCCHHCCCCCEECCCCCEEEEE
KPDTKTFPCLSLAYQAGKIGGSMPCVLNAANEQAVYQFLAKKITFLQIPELIEKVMEKHE
CCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKNPSIENLISVDNWARKATDENIT
HHCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFEKNISILGSTGSIGTQTLEIVENNPDKYNVVALTTNSNIDTLINQAKKFHPNLLVVND
CCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEC
SSLKDELWNKLKEENLNNIKIASGQEGMIQAGEMAEAELVVVSVVGFSGVIPTISALKAD
CHHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCCCCEEEEEEECCCCCHHHHHHHHCCC
KDVALANKETLVAAGEQVMRLSHQSKGRLLPIDSEHSAIFQALMGEKNDSVNKLILTASG
CCEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEEEECC
GPFFGKTKEELYNISPKDALKHPNWDMGNKISIDSATLMNKGLEVIEAHWLFNIPFEQID
CCCCCCCHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHCCHHHEEEEEEEECCHHHEE
VVIHPQSIVHSLVEFVDGAMKAELGLPDMRIPIQFALGYPQREANNFERLDLTDFDLTFK
EEECCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEEECCCCHHCCCCCEECCCCCEEEEE
KPDTKTFPCLSLAYQAGKIGGSMPCVLNAANEQAVYQFLAKKITFLQIPELIEKVMEKHE
CCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKNPSIENLISVDNWARKATDENIT
HHCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]