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The map label for this gene is xerC

Identifier: 188586009

GI number: 188586009

Start: 1455451

End: 1456350

Strand: Direct

Name: xerC

Synonym: Nther_1383

Alternate gene names: 188586009

Gene position: 1455451-1456350 (Clockwise)

Preceding gene: 188586008

Following gene: 188586010

Centisome position: 45.98

GC content: 36.33

Gene sequence:

>900_bases
TTGAGAAACGAGTTGCTCGACTTTTTGGAATTTTTAAAAGGAGAAAAGAATTTATCCCATTATACCGTAGACAATTACTA
TAAAGACCTTACTCAGGCAGAAAACTTTTTTAATGAACAATTTGAGCTATATCAATGGGATGAAGTGACACATAAACATA
TTAGACATTTTCTTGCCTATTTAAAAGATAAAAACTACGAAAAAAGCACAACGGCTAGAAAGTTGTCAGCTATTAGGTCA
TTGTTCAAATTTTTAACCAGGGAAGAAAAAATAAGGTCTAACACTAGCGCTTTATTAGCCACACCAAAAAAAGAGCGCAA
ACTACCGGAGTTTTTGTCAATAGAAGAAGTTGAAATGTTGATAAATGCCCCAGGTGATGATCCTTTTGGACTCCGTGATA
AGGCAATCTTGGAGGTTTTTTATTGTTCAGGCATAAGGCTAGGAGAATTATGGGGCCTTGATTTACAAAATTTAGATTTA
CAAACTGGTTACTTAAAAGTGACTGGAAAAGGCAATATTGAGCGGTTGGCACCCTTGGGAAGCTTTGCCTTGGCAGCTAT
AGAAGATTATCTTTATAATGCCAGGCCTGAATTACTTAAAAAGAATAAGTCAGTTGAAAACTGTGATGCCTTATTCTTGA
ATAAATTTGGAACAAGGATATCTCAGCGCAGTATTAGGAGAAGGGTAAAAAAATACGTCCAACAAACTGCCTCAGAACAT
AGAGTTTCTCCTCATAGTTTAAGACATAGTTTTGCAACCCATTTACTAGAAGGTGGTGCCGATCTCAGGGCTGTTCAAGA
ATTACTGGGACATGTGAATATATCTACGACTCAAATTTATACCCATGTTAATCAAGCCAGGATGACGGAGGTTTACAATA
AATATCATCCCAGGGCTTAA

Upstream 100 bases:

>100_bases
TAAAAATATTGGAAGAATTTATTGAAAGAAAATTGTAACTATTTTAGTTGCAAATCTTTTACGAATTGTGTTATGATTTG
TCAGAAGGGAGAACTCGAAA

Downstream 100 bases:

>100_bases
AATTATATTATCACGAATGAAGTTTTAAGGTGGTGAACATTATGCTTGATGGTACTACAATAGCAGCATGTAAAACCGAT
AAAGGAACTGCCATTGCAGG

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRNELLDFLEFLKGEKNLSHYTVDNYYKDLTQAENFFNEQFELYQWDEVTHKHIRHFLAYLKDKNYEKSTTARKLSAIRS
LFKFLTREEKIRSNTSALLATPKKERKLPEFLSIEEVEMLINAPGDDPFGLRDKAILEVFYCSGIRLGELWGLDLQNLDL
QTGYLKVTGKGNIERLAPLGSFALAAIEDYLYNARPELLKKNKSVENCDALFLNKFGTRISQRSIRRRVKKYVQQTASEH
RVSPHSLRHSFATHLLEGGADLRAVQELLGHVNISTTQIYTHVNQARMTEVYNKYHPRA

Sequences:

>Translated_299_residues
MRNELLDFLEFLKGEKNLSHYTVDNYYKDLTQAENFFNEQFELYQWDEVTHKHIRHFLAYLKDKNYEKSTTARKLSAIRS
LFKFLTREEKIRSNTSALLATPKKERKLPEFLSIEEVEMLINAPGDDPFGLRDKAILEVFYCSGIRLGELWGLDLQNLDL
QTGYLKVTGKGNIERLAPLGSFALAAIEDYLYNARPELLKKNKSVENCDALFLNKFGTRISQRSIRRRVKKYVQQTASEH
RVSPHSLRHSFATHLLEGGADLRAVQELLGHVNISTTQIYTHVNQARMTEVYNKYHPRA
>Mature_299_residues
MRNELLDFLEFLKGEKNLSHYTVDNYYKDLTQAENFFNEQFELYQWDEVTHKHIRHFLAYLKDKNYEKSTTARKLSAIRS
LFKFLTREEKIRSNTSALLATPKKERKLPEFLSIEEVEMLINAPGDDPFGLRDKAILEVFYCSGIRLGELWGLDLQNLDL
QTGYLKVTGKGNIERLAPLGSFALAAIEDYLYNARPELLKKNKSVENCDALFLNKFGTRISQRSIRRRVKKYVQQTASEH
RVSPHSLRHSFATHLLEGGADLRAVQELLGHVNISTTQIYTHVNQARMTEVYNKYHPRA

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=292, Percent_Identity=40.4109589041096, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1789261, Length=297, Percent_Identity=41.7508417508418, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790768, Length=185, Percent_Identity=29.1891891891892, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790767, Length=198, Percent_Identity=24.7474747474747, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_NATTJ (B2A335)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917554.1
- ProteinModelPortal:   B2A335
- SMR:   B2A335
- GeneID:   6316636
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1383
- HOGENOM:   HBG727654
- OMA:   DESEYLL
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 34775; Mature: 34775

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: ACT_SITE 146-146 ACT_SITE 170-170 ACT_SITE 245-245 ACT_SITE 248-248 ACT_SITE 271-271 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNELLDFLEFLKGEKNLSHYTVDNYYKDLTQAENFFNEQFELYQWDEVTHKHIRHFLAY
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKDKNYEKSTTARKLSAIRSLFKFLTREEKIRSNTSALLATPKKERKLPEFLSIEEVEML
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHCCHHHHHHHHHHHH
INAPGDDPFGLRDKAILEVFYCSGIRLGELWGLDLQNLDLQTGYLKVTGKGNIERLAPLG
HCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHH
SFALAAIEDYLYNARPELLKKNKSVENCDALFLNKFGTRISQRSIRRRVKKYVQQTASEH
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVSPHSLRHSFATHLLEGGADLRAVQELLGHVNISTTQIYTHVNQARMTEVYNKYHPRA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRNELLDFLEFLKGEKNLSHYTVDNYYKDLTQAENFFNEQFELYQWDEVTHKHIRHFLAY
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKDKNYEKSTTARKLSAIRSLFKFLTREEKIRSNTSALLATPKKERKLPEFLSIEEVEML
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHCCHHHHHHHHHHHH
INAPGDDPFGLRDKAILEVFYCSGIRLGELWGLDLQNLDLQTGYLKVTGKGNIERLAPLG
HCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHH
SFALAAIEDYLYNARPELLKKNKSVENCDALFLNKFGTRISQRSIRRRVKKYVQQTASEH
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVSPHSLRHSFATHLLEGGADLRAVQELLGHVNISTTQIYTHVNQARMTEVYNKYHPRA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA