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The map label for this gene is rnc

Identifier: 188585989

GI number: 188585989

Start: 1434493

End: 1435185

Strand: Direct

Name: rnc

Synonym: Nther_1363

Alternate gene names: 188585989

Gene position: 1434493-1435185 (Clockwise)

Preceding gene: 188585988

Following gene: 188585990

Centisome position: 45.32

GC content: 35.64

Gene sequence:

>693_bases
ATGGGTAAGGAATGCCGCGATATTGTTGAACTAAAAGAAAAGTTAGGTATTTATGTGGATGATAAGTTACTACTACAAGC
AGTGACTCATACTTCCTATGCCCATGAACAAAAAGATGTTGTTGATCACAATGAAAGGCTTGAGTTTTTAGGAGATGCTG
TTTTAGAACTGGCAATCAGCGAAACATTATATAAAAAATACCCTGAGCTACCTGAGGGTGAGCTTACCAAATTAAGAGCA
GAGTTAGTGTGCGAATTATCTTTAGTTAAAATTGCAGAAAAATTAGATCTGGGAAAATATTTAAGGTTAGGCAAAGGCGA
GGATAGTACTGGAGGAAGAGACCGGCGTTCTACCCTGGCAGATACAGTTGAAGCTTTAATTGGAGCTGTTTACTTACAAA
CAAATTACGATCAAACGAAACAACTGATTCTTGACTTATTTAAAGATCAATTAAGTCATATTGATAATCAACGGATTGGT
GATTATAAAACTATGATACAAGAATTAGTACAGGATAGATATGGTGATCCACCTAAATATCAAATTGTTAAAGAATCGGG
TCCAGATCATGACAAGAGTTTTGTTGCTGAAGTCCAAATTAACAATGAAGTCGTGGGTAGAGGCAGTGGTAAAAGCAAAA
AAGAGGCAGAACAGAATGCGGCTCATTTTGCTTTTCAAAAATTAAGTAAATAA

Upstream 100 bases:

>100_bases
CTAGATACTACTTTAGTGAATAATTTTGGCTTTGGTGGGACAAATGCTAGCTTAATTTTTAAAAGCTTGAAGGATTAACT
ATTTAAGTGAGGGATGTAAA

Downstream 100 bases:

>100_bases
ATTAATTTTAACCAAGTGGCAGGAATTTGCTATGAACATATAGTATATTATAAAGTAAGCTAAAACAATTCAATTAAAGT
TTTGGTGCATTTCAAAGTTA

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MGKECRDIVELKEKLGIYVDDKLLLQAVTHTSYAHEQKDVVDHNERLEFLGDAVLELAISETLYKKYPELPEGELTKLRA
ELVCELSLVKIAEKLDLGKYLRLGKGEDSTGGRDRRSTLADTVEALIGAVYLQTNYDQTKQLILDLFKDQLSHIDNQRIG
DYKTMIQELVQDRYGDPPKYQIVKESGPDHDKSFVAEVQINNEVVGRGSGKSKKEAEQNAAHFAFQKLSK

Sequences:

>Translated_230_residues
MGKECRDIVELKEKLGIYVDDKLLLQAVTHTSYAHEQKDVVDHNERLEFLGDAVLELAISETLYKKYPELPEGELTKLRA
ELVCELSLVKIAEKLDLGKYLRLGKGEDSTGGRDRRSTLADTVEALIGAVYLQTNYDQTKQLILDLFKDQLSHIDNQRIG
DYKTMIQELVQDRYGDPPKYQIVKESGPDHDKSFVAEVQINNEVVGRGSGKSKKEAEQNAAHFAFQKLSK
>Mature_229_residues
GKECRDIVELKEKLGIYVDDKLLLQAVTHTSYAHEQKDVVDHNERLEFLGDAVLELAISETLYKKYPELPEGELTKLRAE
LVCELSLVKIAEKLDLGKYLRLGKGEDSTGGRDRRSTLADTVEALIGAVYLQTNYDQTKQLILDLFKDQLSHIDNQRIGD
YKTMIQELVQDRYGDPPKYQIVKESGPDHDKSFVAEVQINNEVVGRGSGKSKKEAEQNAAHFAFQKLSK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=29.6943231441048, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=29.6943231441048, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1788920, Length=213, Percent_Identity=40.8450704225352, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17506883, Length=228, Percent_Identity=27.1929824561404, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=228, Percent_Identity=27.1929824561404, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137682, Length=224, Percent_Identity=30.8035714285714, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_NATTJ (B2A2N1)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917534.1
- ProteinModelPortal:   B2A2N1
- SMR:   B2A2N1
- GeneID:   6314537
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1363
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26040; Mature: 25909

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKECRDIVELKEKLGIYVDDKLLLQAVTHTSYAHEQKDVVDHNERLEFLGDAVLELAIS
CCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLYKKYPELPEGELTKLRAELVCELSLVKIAEKLDLGKYLRLGKGEDSTGGRDRRSTLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
DTVEALIGAVYLQTNYDQTKQLILDLFKDQLSHIDNQRIGDYKTMIQELVQDRYGDPPKY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCE
QIVKESGPDHDKSFVAEVQINNEVVGRGSGKSKKEAEQNAAHFAFQKLSK
EEECCCCCCCCHHEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKECRDIVELKEKLGIYVDDKLLLQAVTHTSYAHEQKDVVDHNERLEFLGDAVLELAIS
CHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLYKKYPELPEGELTKLRAELVCELSLVKIAEKLDLGKYLRLGKGEDSTGGRDRRSTLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
DTVEALIGAVYLQTNYDQTKQLILDLFKDQLSHIDNQRIGDYKTMIQELVQDRYGDPPKY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCE
QIVKESGPDHDKSFVAEVQINNEVVGRGSGKSKKEAEQNAAHFAFQKLSK
EEECCCCCCCCHHEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA