Click here to switch to the map view.

The map label for this gene is fabH

Identifier: 188585983

GI number: 188585983

Start: 1429161

End: 1430150

Strand: Direct

Name: fabH

Synonym: Nther_1357

Alternate gene names: 188585983

Gene position: 1429161-1430150 (Clockwise)

Preceding gene: 188585982

Following gene: 188585984

Centisome position: 45.15

GC content: 39.49

Gene sequence:

>990_bases
ATGAGTAATGCGAAAATACTGGCCACAGGAAAAAGTGTACCTGATTCAATTTTCACCAATGAAGATTTGGAGAAGATGGT
GGAAACCAGTGATAGTTGGATCACATCAAGAACAGGCATCAAGGAACGTAGGATTGCAGATGAAAACACAGCTACGTCTC
ATTTGTCAGTACAAGCGGCCGAAATAGCTTTGAACAAATCTGGAATTGAACCAGCCGATTTGGATATGATCATTGTAGCT
ACGGTTACTCCTGACATGGCTTTCCCTTCTACGGCTTGCCTTGTTCAAGATAAATTAGGAGCTGATCAAGCATGTGCATT
TGACTTGGAAGCTGCCTGTACAGGCTTTTTGTATGGATTGCGGATAGCCAGTCAGTTTATAGCTACTGATACCCATAAAT
ATATCTTGGTTATAGGATCAGAAACCCTGTCCAAAATTGTTGATTGGGAAGATAGAAACACCTGCGTTCTTTTTGGTGAT
GGAGCCGGCGCAGCAGTACTTGGCCCTGTAGAGAATGGTGAAGAAGACAAAGGTTTGATCTCTTTTGATTTAGGTGCTGA
TGGCTCCAAGGGGGAATTATTGCAGCAACCTGCAGGAGGTTCCTTAAAGCCGGCTACATTAGAAACAGTTAGTAGTAAAG
AGCATTTTATCAAAATGAATGGAAATGAAGTCTTTAAATTTGCTGTGAAAGTTATTGGTGATACAACGGAAAAGGCTTTG
AAAAAAATTGACAAAACAACTGAAGATATTGATTTATTTATTCCTCATCAGGCAAATCAGAGAATTATTGATTCCGCTAC
TAATCGTCTTGGTATAAGTAAGGAGAAAACTTTTGTTAATCTACAAAATTATGGAAATATGTCAGCAGCTTCGATTCCGG
TTGCTTTAGATGAAGCTATTGAAGAAAATTTAATAAAGGAAGATGACTTGGTTGCCTTAGTAGGTTTTGGTGGAGGTTTG
ACCTGGGGCTCTTGTCTCATTAAATGGTAG

Upstream 100 bases:

>100_bases
ACCGCCATTAAAAATGCTATTGTGCGCCAAGTATATCATTTTGTCAATAACGAAGTTTTGACGGCTTTTTCACAGGAAAT
AGAGAAAGGGGTAGAAACTG

Downstream 100 bases:

>100_bases
TAGAAAATGGAGGGTTTATCATGAATACTAAACAATTATTACAATTACTTGATATTGATTATCCTATAATTCAAGGTGGG
ATGGCTTGGGTTGCCACAGG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAAEIALNKSGIEPADLDMIIVA
TVTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGLRIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGD
GAGAAVLGPVENGEEDKGLISFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKAL
KKIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAIEENLIKEDDLVALVGFGGGL
TWGSCLIKW

Sequences:

>Translated_329_residues
MSNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAAEIALNKSGIEPADLDMIIVA
TVTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGLRIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGD
GAGAAVLGPVENGEEDKGLISFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKAL
KKIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAIEENLIKEDDLVALVGFGGGL
TWGSCLIKW
>Mature_328_residues
SNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAAEIALNKSGIEPADLDMIIVAT
VTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGLRIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGDG
AGAAVLGPVENGEEDKGLISFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKALK
KIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAIEENLIKEDDLVALVGFGGGLT
WGSCLIKW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=325, Percent_Identity=44.6153846153846, Blast_Score=278, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_NATTJ (B2A2M5)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917528.1
- ProteinModelPortal:   B2A2M5
- SMR:   B2A2M5
- GeneID:   6314531
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1357
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35308; Mature: 35177

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 256-256 ACT_SITE 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAA
CCCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCEEEEEEE
EIALNKSGIEPADLDMIIVATVTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGL
EEEECCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEHHCCCCCCEEEEHHHHHHHHHHHH
RIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGDGAGAAVLGPVENGEEDKGLI
HHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCCEE
SFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKAL
EEECCCCCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHH
KKIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAI
HHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
EENLIKEDDLVALVGFGGGLTWGSCLIKW
HHHCCCCCCEEEEEECCCCCCCCCEEECC
>Mature Secondary Structure 
SNAKILATGKSVPDSIFTNEDLEKMVETSDSWITSRTGIKERRIADENTATSHLSVQAA
CCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCEEEEEEE
EIALNKSGIEPADLDMIIVATVTPDMAFPSTACLVQDKLGADQACAFDLEAACTGFLYGL
EEEECCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEHHCCCCCCEEEEHHHHHHHHHHHH
RIASQFIATDTHKYILVIGSETLSKIVDWEDRNTCVLFGDGAGAAVLGPVENGEEDKGLI
HHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCCEE
SFDLGADGSKGELLQQPAGGSLKPATLETVSSKEHFIKMNGNEVFKFAVKVIGDTTEKAL
EEECCCCCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHH
KKIDKTTEDIDLFIPHQANQRIIDSATNRLGISKEKTFVNLQNYGNMSAASIPVALDEAI
HHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
EENLIKEDDLVALVGFGGGLTWGSCLIKW
HHHCCCCCCEEEEEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA