Click here to switch to the map view.

The map label for this gene is coaD

Identifier: 188585975

GI number: 188585975

Start: 1422211

End: 1422699

Strand: Direct

Name: coaD

Synonym: Nther_1349

Alternate gene names: 188585975

Gene position: 1422211-1422699 (Clockwise)

Preceding gene: 188585974

Following gene: 188585977

Centisome position: 44.93

GC content: 32.52

Gene sequence:

>489_bases
ATGAAAACGGTAATTTATCCCGGAAGTTTTGATCCACCAACAAATGGCCATTTGGATATTATTCAAAGAGCTGCTCGGGT
TTTTGATAAAGTTATAGTTGCTGTGTTAAATAATCCAGAGAAAAACCCTATGTTTACAGTGGCAGAACGTCGAAAAATGT
TGGAAATGATCACTAAGGAATATGCCAATGTAGAAATTGATGATTTTAATGGGTTACTAGTTGATTATGTTAGAGAAAAA
CAAGTTAGCATAGTTATTAAAGGTCTTCGAGCTATATCGGATTTTGAAAATGAAATGCAAATGGCTCTGACGAATAGAAA
ATTAGCACCTGATATTGAAACTATTTTCATGATGACTAATCATAAATGTTCATTTTTAAGTTCCAGTGTAGTAAAAGAAG
TAGTAGCTTTTGATGGATGTATTGAGGGATTAGTACCAGAACAAATTCAAGACTACATTATTGAAAAAAGGAACTCTCAA
AGGAAATGA

Upstream 100 bases:

>100_bases
AATTAATTGAAACTGAGCTAAAACTATGGAAACAAGTAAAGGAAAAAAATTATGGTGATACTACAATTACAATCCTAACA
CCGTTAAGGAGTGAATAGTT

Downstream 100 bases:

>100_bases
TATCATATATCCGTAATTATTTACGGTTTTTAAACAGGACTAATACTTTTTTGCTAATCCCTAGAGTATATAATAACATT
AGTAAAATTGTGAACAATAT

Product: Phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKTVIYPGSFDPPTNGHLDIIQRAARVFDKVIVAVLNNPEKNPMFTVAERRKMLEMITKEYANVEIDDFNGLLVDYVREK
QVSIVIKGLRAISDFENEMQMALTNRKLAPDIETIFMMTNHKCSFLSSSVVKEVVAFDGCIEGLVPEQIQDYIIEKRNSQ
RK

Sequences:

>Translated_162_residues
MKTVIYPGSFDPPTNGHLDIIQRAARVFDKVIVAVLNNPEKNPMFTVAERRKMLEMITKEYANVEIDDFNGLLVDYVREK
QVSIVIKGLRAISDFENEMQMALTNRKLAPDIETIFMMTNHKCSFLSSSVVKEVVAFDGCIEGLVPEQIQDYIIEKRNSQ
RK
>Mature_162_residues
MKTVIYPGSFDPPTNGHLDIIQRAARVFDKVIVAVLNNPEKNPMFTVAERRKMLEMITKEYANVEIDDFNGLLVDYVREK
QVSIVIKGLRAISDFENEMQMALTNRKLAPDIETIFMMTNHKCSFLSSSVVKEVVAFDGCIEGLVPEQIQDYIIEKRNSQ
RK

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=155, Percent_Identity=43.8709677419355, Blast_Score=159, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_NATTJ (B2A2L7)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917520.1
- ProteinModelPortal:   B2A2L7
- SMR:   B2A2L7
- GeneID:   6315598
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1349
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 18543; Mature: 18543

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVIYPGSFDPPTNGHLDIIQRAARVFDKVIVAVLNNPEKNPMFTVAERRKMLEMITKE
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHH
YANVEIDDFNGLLVDYVREKQVSIVIKGLRAISDFENEMQMALTNRKLAPDIETIFMMTN
HCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECC
HKCSFLSSSVVKEVVAFDGCIEGLVPEQIQDYIIEKRNSQRK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKTVIYPGSFDPPTNGHLDIIQRAARVFDKVIVAVLNNPEKNPMFTVAERRKMLEMITKE
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHH
YANVEIDDFNGLLVDYVREKQVSIVIKGLRAISDFENEMQMALTNRKLAPDIETIFMMTN
HCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECC
HKCSFLSSSVVKEVVAFDGCIEGLVPEQIQDYIIEKRNSQRK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA