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The map label for this gene is gmk [H]

Identifier: 188585955

GI number: 188585955

Start: 1402944

End: 1403558

Strand: Direct

Name: gmk [H]

Synonym: Nther_1329

Alternate gene names: 188585955

Gene position: 1402944-1403558 (Clockwise)

Preceding gene: 188585954

Following gene: 188585956

Centisome position: 44.32

GC content: 34.96

Gene sequence:

>615_bases
ATGAAAAAAGAAGGTTTACTAGTAGTTCTTTCTGGTCCATCAGGAGTAGGAAAAGGTACTATTTGTGATCATTTACTTGA
TAAATACTCGGATTTGGAATATTCTATCTCTATGACTACCAGATCTCCAAGAGCTGGAGAAATCCATGGAGAAGATTATT
ACTTTGTTTCGAAAAGTGAATTTCAAGAAATGATCGCTGATGATGAATTTTTAGAGTGGGCAGAAGTATTTGGTAATTAT
TACGGGACACCAAGAAAATTTGTCAACTCTAAACTTAGAGAAGGTAAAAGTGTTGTCTTAGAAATTGATATTCAAGGAGC
ATTACAGGTAAAGCAACGATGTCCAAATGGTGTATTTATTTTCTTATTACCACCATCCTTGGATGAATTACACAAGCGTA
TCCGAAAGCGGGGAACTGAACAAGATAAGGATATGCAGACGCGATTAACGGCAGCAAAAAATGAAATTAAAACTGTACAT
CAATACGACTATGCAGTTGTTAATAATAATATAGGTGACACTGCTGACTTGATTTATTCAGTTATCAAAGCTGAAAAATG
CAGTGTTAGCAGGGTTGGACAAAAACTCGTTAAAGAGGTGATAGATAATGAATGA

Upstream 100 bases:

>100_bases
TATTTTATCAGCTGTTCAACCGGAAACAGTTAAACAAAGACTACACACTGATTCCTCAGAGGACGATGAAGAAATAAATT
AAATATAGGTGGGACAAACT

Downstream 100 bases:

>100_bases
ACCTGCAGTTGATAACTTAGTAGAACAGGTGGAGAGTAAGTACTCTCTGGTTATTGCTGTTGCCAAGCGAGCAAGGGAGA
TAGTGGATGGCTCTCCTTCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MKKEGLLVVLSGPSGVGKGTICDHLLDKYSDLEYSISMTTRSPRAGEIHGEDYYFVSKSEFQEMIADDEFLEWAEVFGNY
YGTPRKFVNSKLREGKSVVLEIDIQGALQVKQRCPNGVFIFLLPPSLDELHKRIRKRGTEQDKDMQTRLTAAKNEIKTVH
QYDYAVVNNNIGDTADLIYSVIKAEKCSVSRVGQKLVKEVIDNE

Sequences:

>Translated_204_residues
MKKEGLLVVLSGPSGVGKGTICDHLLDKYSDLEYSISMTTRSPRAGEIHGEDYYFVSKSEFQEMIADDEFLEWAEVFGNY
YGTPRKFVNSKLREGKSVVLEIDIQGALQVKQRCPNGVFIFLLPPSLDELHKRIRKRGTEQDKDMQTRLTAAKNEIKTVH
QYDYAVVNNNIGDTADLIYSVIKAEKCSVSRVGQKLVKEVIDNE
>Mature_204_residues
MKKEGLLVVLSGPSGVGKGTICDHLLDKYSDLEYSISMTTRSPRAGEIHGEDYYFVSKSEFQEMIADDEFLEWAEVFGNY
YGTPRKFVNSKLREGKSVVLEIDIQGALQVKQRCPNGVFIFLLPPSLDELHKRIRKRGTEQDKDMQTRLTAAKNEIKTVH
QYDYAVVNNNIGDTADLIYSVIKAEKCSVSRVGQKLVKEVIDNE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=180, Percent_Identity=38.3333333333333, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4504221, Length=180, Percent_Identity=38.3333333333333, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI226874831, Length=180, Percent_Identity=38.3333333333333, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI14780902, Length=196, Percent_Identity=30.6122448979592, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4505237, Length=168, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=168, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI38570142, Length=167, Percent_Identity=28.7425149700599, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI262118255, Length=168, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI262118263, Length=168, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186972120, Length=171, Percent_Identity=29.2397660818713, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI186700627, Length=171, Percent_Identity=29.2397660818713, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI186700629, Length=171, Percent_Identity=29.2397660818713, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=43.298969072165, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=169, Percent_Identity=40.2366863905325, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=169, Percent_Identity=40.2366863905325, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=167, Percent_Identity=32.3353293413174, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=174, Percent_Identity=29.3103448275862, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=174, Percent_Identity=29.3103448275862, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=42.3913043478261, Blast_Score=150, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356141, Length=165, Percent_Identity=42.4242424242424, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI116007136, Length=198, Percent_Identity=25.2525252525253, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554489, Length=198, Percent_Identity=25.2525252525253, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI85724806, Length=198, Percent_Identity=25.2525252525253, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554481, Length=198, Percent_Identity=25.2525252525253, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640542, Length=198, Percent_Identity=25.2525252525253, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077626, Length=198, Percent_Identity=25.2525252525253, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648808, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362230, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161078487, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161078485, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648810, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281362232, Length=178, Percent_Identity=28.6516853932584, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554813, Length=181, Percent_Identity=32.5966850828729, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23086; Mature: 23086

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEGLLVVLSGPSGVGKGTICDHLLDKYSDLEYSISMTTRSPRAGEIHGEDYYFVSKSE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECHHH
FQEMIADDEFLEWAEVFGNYYGTPRKFVNSKLREGKSVVLEIDIQGALQVKQRCPNGVFI
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCEEE
FLLPPSLDELHKRIRKRGTEQDKDMQTRLTAAKNEIKTVHQYDYAVVNNNIGDTADLIYS
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHH
VIKAEKCSVSRVGQKLVKEVIDNE
HHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKEGLLVVLSGPSGVGKGTICDHLLDKYSDLEYSISMTTRSPRAGEIHGEDYYFVSKSE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECHHH
FQEMIADDEFLEWAEVFGNYYGTPRKFVNSKLREGKSVVLEIDIQGALQVKQRCPNGVFI
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCEEE
FLLPPSLDELHKRIRKRGTEQDKDMQTRLTAAKNEIKTVHQYDYAVVNNNIGDTADLIYS
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHH
VIKAEKCSVSRVGQKLVKEVIDNE
HHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]