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The map label for this gene is aroB

Identifier: 188585907

GI number: 188585907

Start: 1350149

End: 1351255

Strand: Direct

Name: aroB

Synonym: Nther_1281

Alternate gene names: 188585907

Gene position: 1350149-1351255 (Clockwise)

Preceding gene: 188585906

Following gene: 188585908

Centisome position: 42.65

GC content: 37.22

Gene sequence:

>1107_bases
TTGAAAAATAAATTTGACACTTTAACAGTTGAAACAGGGGTTAAATCCAAAAAAAAGTATCCTATCTATATTGGTAAAGC
CATTCTCAATCTGTTAGATAAGGTGATACCAAGAAATGTAAGTGTTTTGATAGTTATTGATTCGCGGATAGCAAGGTTGC
ACAGGGATAAAATCACACGATTGATAGAGTTTTTAACCGAGTCGCGAACGGTCAATCAAATTATCATACCAGGAGAAGAG
GATAGCAAGTCTTTATCAGTTTCAGAATCGCTATATGAGAAGGCTGCTAGCCTTAATCTTGACAGGTCTTCTTGGTTCAT
TGGGATTGGTGGTGGTGTCGTAGGAGACTTAACAGGTTTTGTAGCAGCTACTTACATGCGTGGGGCTAATCTCCTTCATG
TACCGACAACCTTACTTGCTCAGGTGGATAGCAGTGTTGGAGGAAAGGTTGCAATAAATCAAAGTGGCTATAAAAATTTA
GTAGGTAATTTCTATCAGCCCAAAGCAGTAATAATAGATACAAATTTTTTAGATACTCTTCCCATCAGGGAACTCAGGGC
TGGTTTGGCAGAAGTTTTTAAATATGGTATTCTATGTGACCGGGAGTTATTTTTAACAGTGAAATCTTTATTTGAAGACT
GTGAACCCCTTAATAATGTTTCCTGGGAAAGGTATTCGTATCTAATCCACAAATCTTGTGAAATCAAAGCAGATATTGTA
TCTCAGGATGAAATTGATACTGGCATTAGGATGTTGTTAAATTTAGGGCATACCTTCGCTCATGCCCTGGAAGGAGCAAC
ATCTTATAACTATTTTAAGCATGGAGAAGCTGTGATGTGGGGACTTGCCATGTCAGCAGAACTTTCCTATAAACTAAACA
AGCTGACCTATAAGGATTATCAAGCAATCGCCGAGTTACCAGAGTTAACAAAAGTTCCAGAAGTACCTATACAAGTTAAA
GACCCAAATATAATTGAGGAATTGCTGCTTAGAGATAAGAAAAAAACTGGAGAAGAGTTAACAGTAATTTTACCTACATC
AATTGGATCAGCTGAAATTTGTAAATGTCCCGCAACAGCACTGATAAAAGTTATTCTAGAATCATAG

Upstream 100 bases:

>100_bases
AGTGAAAGAAAAATTTGGTAGTGATTCAATAGATGAATTGAGACGAAATTATCAAGCTTACTTTGAGTATTTAGATACTA
GATAATATAGGGGGATTTTT

Downstream 100 bases:

>100_bases
GAGGTGTTGCTATGGCAGATCTTAAAAAGCTGATAGCCACTCTTTCCAGGATCGATGGGAAAGGCTATAAGGCCTATAAA
GACATTCAAGGGATGTATAA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKNKFDTLTVETGVKSKKKYPIYIGKAILNLLDKVIPRNVSVLIVIDSRIARLHRDKITRLIEFLTESRTVNQIIIPGEE
DSKSLSVSESLYEKAASLNLDRSSWFIGIGGGVVGDLTGFVAATYMRGANLLHVPTTLLAQVDSSVGGKVAINQSGYKNL
VGNFYQPKAVIIDTNFLDTLPIRELRAGLAEVFKYGILCDRELFLTVKSLFEDCEPLNNVSWERYSYLIHKSCEIKADIV
SQDEIDTGIRMLLNLGHTFAHALEGATSYNYFKHGEAVMWGLAMSAELSYKLNKLTYKDYQAIAELPELTKVPEVPIQVK
DPNIIEELLLRDKKKTGEELTVILPTSIGSAEICKCPATALIKVILES

Sequences:

>Translated_368_residues
MKNKFDTLTVETGVKSKKKYPIYIGKAILNLLDKVIPRNVSVLIVIDSRIARLHRDKITRLIEFLTESRTVNQIIIPGEE
DSKSLSVSESLYEKAASLNLDRSSWFIGIGGGVVGDLTGFVAATYMRGANLLHVPTTLLAQVDSSVGGKVAINQSGYKNL
VGNFYQPKAVIIDTNFLDTLPIRELRAGLAEVFKYGILCDRELFLTVKSLFEDCEPLNNVSWERYSYLIHKSCEIKADIV
SQDEIDTGIRMLLNLGHTFAHALEGATSYNYFKHGEAVMWGLAMSAELSYKLNKLTYKDYQAIAELPELTKVPEVPIQVK
DPNIIEELLLRDKKKTGEELTVILPTSIGSAEICKCPATALIKVILES
>Mature_368_residues
MKNKFDTLTVETGVKSKKKYPIYIGKAILNLLDKVIPRNVSVLIVIDSRIARLHRDKITRLIEFLTESRTVNQIIIPGEE
DSKSLSVSESLYEKAASLNLDRSSWFIGIGGGVVGDLTGFVAATYMRGANLLHVPTTLLAQVDSSVGGKVAINQSGYKNL
VGNFYQPKAVIIDTNFLDTLPIRELRAGLAEVFKYGILCDRELFLTVKSLFEDCEPLNNVSWERYSYLIHKSCEIKADIV
SQDEIDTGIRMLLNLGHTFAHALEGATSYNYFKHGEAVMWGLAMSAELSYKLNKLTYKDYQAIAELPELTKVPEVPIQVK
DPNIIEELLLRDKKKTGEELTVILPTSIGSAEICKCPATALIKVILES

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=345, Percent_Identity=40, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320332, Length=316, Percent_Identity=33.8607594936709, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_NATTJ (B2A259)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917452.1
- ProteinModelPortal:   B2A259
- SMR:   B2A259
- GeneID:   6315527
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1281
- HOGENOM:   HBG632303
- OMA:   SEIVEIC
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40931; Mature: 40931

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKFDTLTVETGVKSKKKYPIYIGKAILNLLDKVIPRNVSVLIVIDSRIARLHRDKITR
CCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LIEFLTESRTVNQIIIPGEEDSKSLSVSESLYEKAASLNLDRSSWFIGIGGGVVGDLTGF
HHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
VAATYMRGANLLHVPTTLLAQVDSSVGGKVAINQSGYKNLVGNFYQPKAVIIDTNFLDTL
HHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCEEEEECCCCCCC
PIRELRAGLAEVFKYGILCDRELFLTVKSLFEDCEPLNNVSWERYSYLIHKSCEIKADIV
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECC
SQDEIDTGIRMLLNLGHTFAHALEGATSYNYFKHGEAVMWGLAMSAELSYKLNKLTYKDY
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHCCHHHH
QAIAELPELTKVPEVPIQVKDPNIIEELLLRDKKKTGEELTVILPTSIGSAEICKCPATA
HHHHHCHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCHHH
LIKVILES
HHHHHHCC
>Mature Secondary Structure
MKNKFDTLTVETGVKSKKKYPIYIGKAILNLLDKVIPRNVSVLIVIDSRIARLHRDKITR
CCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LIEFLTESRTVNQIIIPGEEDSKSLSVSESLYEKAASLNLDRSSWFIGIGGGVVGDLTGF
HHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
VAATYMRGANLLHVPTTLLAQVDSSVGGKVAINQSGYKNLVGNFYQPKAVIIDTNFLDTL
HHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCEEEEECCCCCCC
PIRELRAGLAEVFKYGILCDRELFLTVKSLFEDCEPLNNVSWERYSYLIHKSCEIKADIV
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECC
SQDEIDTGIRMLLNLGHTFAHALEGATSYNYFKHGEAVMWGLAMSAELSYKLNKLTYKDY
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHCCHHHH
QAIAELPELTKVPEVPIQVKDPNIIEELLLRDKKKTGEELTVILPTSIGSAEICKCPATA
HHHHHCHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCHHH
LIKVILES
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA