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The map label for this gene is moaA [H]

Identifier: 188585891

GI number: 188585891

Start: 1336298

End: 1337308

Strand: Direct

Name: moaA [H]

Synonym: Nther_1265

Alternate gene names: 188585891

Gene position: 1336298-1337308 (Clockwise)

Preceding gene: 188585890

Following gene: 188585892

Centisome position: 42.21

GC content: 36.1

Gene sequence:

>1011_bases
ATGACAAATGAATTAGACAAAAATCTAGACATGTACGGAAGACGGATTGACTATTTAAGAATTTCGGTCACTGATAGGTG
TAATCTGCGCTGCTTTTATTGCATGCCAACTAGTGGTGTAGAGAAAATGTCTCACCCCCAAATTTTGAACTTTGAAGATA
TTGAAAGAATAGTAACAGCGGCTGCCAATTTAGGAGTATCAAAAATTAGATTTACGGGGGGCGAACCCCTTGTGCGTAAG
GATTTTTCTAAACTAGTTAATACCATATCAAGAATACCAGGAATAGAGGATCTGTCATTGACTACTAATGGGGTCTTGTT
GGCCCAACAAGGTGAACAGCTCCTAGAAGCTGGAATAAATCGAGTTAATATCAGTTTAGATACCTTAGATAATACTAAAT
TTTCTCAAATTACTAGGGGAGGAACTCTGGCTCAAGTCTTAAAAGGCAAAGAAACTGCTCGGAATTTGGGTTTAACCCCT
TTAAAACTAAATGTTGTGGTTATTAAAGGAATGAATGATGATGAAATTGCTGATTTTGCCAGGTTAACAATGAATGAGGA
TATTGAGGTACGTTTTATTGAATACATGCCCATGAGTGATGGTGAAAATTGGAAAAAATCCTATCTACCAATTACAGATA
TTAAAGAAAAATGTAGTCAAGTTGGCAAATTGTTACCTGTGGAAACGGCAAAAGGAAATGGGCCTGCCAAGTACTATAGA
CTTGAACATGGTGTAGGTAAAATAGGGTTTATTTCCGCTGTAAGTGAGCACTTTTGTGGAGATTGTAATCGTCTTAGGCT
TACTTCCGATGGAAAAATTAAAACATGCTTATTTTCCGATGAAGAATTGGACTTAAGAGTAGCTTTAAAATCTAATTATG
ATATAGAGAGATTGTTACTTAAAGCTATATTAGCAAAACCTAGCCAGCATAATCTTTCGACCATTCATTCAGAGGATATG
CTGACAAATGATTTAAATAGAAAGAGAGGGATGAGTCAAATTGGAGGCTAA

Upstream 100 bases:

>100_bases
CGTTAGGAAAAAGGGGAAACCCTTTTTCCCCCCGTGCTTGGAAAGGAGAACTGCATCAACTGTTTCCAAGCAGTTGATGT
TTATTTATGGAGGGAATAAA

Downstream 100 bases:

>100_bases
TAAAAATAATCAAACAAGAAGGGCTGAGGTAGTAGCTGTTTGCAAGAGTGGACAAACAGGTGAACGAAAGTCAGTAGTTG
ATGAAGGGAAACTTATTGAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTNELDKNLDMYGRRIDYLRISVTDRCNLRCFYCMPTSGVEKMSHPQILNFEDIERIVTAAANLGVSKIRFTGGEPLVRK
DFSKLVNTISRIPGIEDLSLTTNGVLLAQQGEQLLEAGINRVNISLDTLDNTKFSQITRGGTLAQVLKGKETARNLGLTP
LKLNVVVIKGMNDDEIADFARLTMNEDIEVRFIEYMPMSDGENWKKSYLPITDIKEKCSQVGKLLPVETAKGNGPAKYYR
LEHGVGKIGFISAVSEHFCGDCNRLRLTSDGKIKTCLFSDEELDLRVALKSNYDIERLLLKAILAKPSQHNLSTIHSEDM
LTNDLNRKRGMSQIGG

Sequences:

>Translated_336_residues
MTNELDKNLDMYGRRIDYLRISVTDRCNLRCFYCMPTSGVEKMSHPQILNFEDIERIVTAAANLGVSKIRFTGGEPLVRK
DFSKLVNTISRIPGIEDLSLTTNGVLLAQQGEQLLEAGINRVNISLDTLDNTKFSQITRGGTLAQVLKGKETARNLGLTP
LKLNVVVIKGMNDDEIADFARLTMNEDIEVRFIEYMPMSDGENWKKSYLPITDIKEKCSQVGKLLPVETAKGNGPAKYYR
LEHGVGKIGFISAVSEHFCGDCNRLRLTSDGKIKTCLFSDEELDLRVALKSNYDIERLLLKAILAKPSQHNLSTIHSEDM
LTNDLNRKRGMSQIGG
>Mature_335_residues
TNELDKNLDMYGRRIDYLRISVTDRCNLRCFYCMPTSGVEKMSHPQILNFEDIERIVTAAANLGVSKIRFTGGEPLVRKD
FSKLVNTISRIPGIEDLSLTTNGVLLAQQGEQLLEAGINRVNISLDTLDNTKFSQITRGGTLAQVLKGKETARNLGLTPL
KLNVVVIKGMNDDEIADFARLTMNEDIEVRFIEYMPMSDGENWKKSYLPITDIKEKCSQVGKLLPVETAKGNGPAKYYRL
EHGVGKIGFISAVSEHFCGDCNRLRLTSDGKIKTCLFSDEELDLRVALKSNYDIERLLLKAILAKPSQHNLSTIHSEDML
TNDLNRKRGMSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=335, Percent_Identity=40.5970149253731, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI22027536, Length=335, Percent_Identity=40.5970149253731, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1786999, Length=332, Percent_Identity=30.7228915662651, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=38.7622149837134, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI32566329, Length=333, Percent_Identity=38.4384384384384, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17561210, Length=333, Percent_Identity=37.5375375375375, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574488, Length=323, Percent_Identity=41.4860681114551, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574490, Length=308, Percent_Identity=42.2077922077922, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37592; Mature: 37461

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNELDKNLDMYGRRIDYLRISVTDRCNLRCFYCMPTSGVEKMSHPQILNFEDIERIVTA
CCCCHHCCHHHHCCEEEEEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHH
AANLGVSKIRFTGGEPLVRKDFSKLVNTISRIPGIEDLSLTTNGVLLAQQGEQLLEAGIN
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCHHHHHCCCC
RVNISLDTLDNTKFSQITRGGTLAQVLKGKETARNLGLTPLKLNVVVIKGMNDDEIADFA
EEEEEEECCCCCHHHHHHCCCHHHHHHHCHHHHHHCCCCEEEEEEEEEECCCCHHHHHHH
RLTMNEDIEVRFIEYMPMSDGENWKKSYLPITDIKEKCSQVGKLLPVETAKGNGPAKYYR
HHHCCCCCEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHCEECEECCCCCCCCEEEE
LEHGVGKIGFISAVSEHFCGDCNRLRLTSDGKIKTCLFSDEELDLRVALKSNYDIERLLL
ECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHH
KAILAKPSQHNLSTIHSEDMLTNDLNRKRGMSQIGG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
TNELDKNLDMYGRRIDYLRISVTDRCNLRCFYCMPTSGVEKMSHPQILNFEDIERIVTA
CCCHHCCHHHHCCEEEEEEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHH
AANLGVSKIRFTGGEPLVRKDFSKLVNTISRIPGIEDLSLTTNGVLLAQQGEQLLEAGIN
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCHHHHHCCCC
RVNISLDTLDNTKFSQITRGGTLAQVLKGKETARNLGLTPLKLNVVVIKGMNDDEIADFA
EEEEEEECCCCCHHHHHHCCCHHHHHHHCHHHHHHCCCCEEEEEEEEEECCCCHHHHHHH
RLTMNEDIEVRFIEYMPMSDGENWKKSYLPITDIKEKCSQVGKLLPVETAKGNGPAKYYR
HHHCCCCCEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHCEECEECCCCCCCCEEEE
LEHGVGKIGFISAVSEHFCGDCNRLRLTSDGKIKTCLFSDEELDLRVALKSNYDIERLLL
ECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHH
KAILAKPSQHNLSTIHSEDMLTNDLNRKRGMSQIGG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA