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The map label for this gene is nuoF2 [H]

Identifier: 188585874

GI number: 188585874

Start: 1316837

End: 1318651

Strand: Direct

Name: nuoF2 [H]

Synonym: Nther_1248

Alternate gene names: 188585874

Gene position: 1316837-1318651 (Clockwise)

Preceding gene: 188585873

Following gene: 188585875

Centisome position: 41.6

GC content: 39.39

Gene sequence:

>1815_bases
ATGGTACCAGTTGTAAAAATCGGAATGGCCAGTTGTGGTATAGCTGCAGGGGCTAAAAAAGTTTATGACCTTTTCTCCGA
TGAAGCTCAAAGTAAAGCTTCTGTTCAAGAAACTGGCTGTGTCGGAATGTGTTTTAAAGAACCTCTGGTTGAAGTGATCG
ATAATGAGGGACGTTTTATTTACGGGGATGTGGATGAGAAAAAAGCGCAGCAAATTATTGAAGATCACTTGGATAATGGT
CAACCTGTAGAGGATTTGATAGTTTATTCTGACAAAATTGAATCTGAAATTCAAAAATATTTGGATAGTCAAAAACGAAT
TTTATTGAAAAACAGTGGTAAAATTGATCCAGAAAATATAGAAAGTTATTTAGAAGAAGGCGGTTATCAAGGCTTATTAA
ATGCTTTAAAAGAAATGACTCCCAAAGATGTGATAGAAGAAGTTCAAAGCTCTGGTCTTAGAGGCCGAGGAGGAGCTGGC
TTTCCTACTTTCAAAAAATGGGAATTTACAAGAATTGAAGAAAGACAGCCTAAATACGTGATTTGCAATGCCGATGAAGG
TGACCCGGGTGCTTTCATGGATAGAAGTGTCTTGGAAAGTGATCCCCATAGTTTACTAGAAGGAATGGCAATTGCCGGTT
ATGCTATTGGGGCTAACACTGGATATATCTATATTAGAGCTGAATATCCACTTGCCGTTAAGAGGCTAGAGATAGCTATA
GAACAGGCTAAAGAAAAGGGTTATTTAGGTAAAAACATTCAAGATACTGGATTTGATTTTGATATATATATTCGTGAAGG
TGCAGGTGCTTTCGTTTGCGGTGAGGAGACAGCGTTAATAGCAAGTATTGAAGGTAAACGTGGAACACCTACTTTTAAAC
CGCCATTCCCAGCCCAAAAAGGTTTATGGACTCAACCAAGTTGTATTAATAACGTAGAAACCTTAGCTAATGTACCCAGG
GTCTTTTTACAAGGAGCTGAAGCTTACAGTGAACTTGGTACTGAAAATAGCAAAGGTACAAAGGTATTTGCCCTGGCTGG
TGACGTAAAACGCGGTGGTTTGATTGAAGTTCCTATGGGAATTAAAATCAAAGATATCGTTTATGAAGTTGGCGGCGGAA
TTGTTGAAGACAAAGGGTTCAAGGCTGTTCAGATAGGCGGACCTTCTGGAGGTTGTATACCTGCTAAATATCAGGATGTA
TCAGTTGATTACGAGTCACTAAATGAGCTAGGTGCTATCATGGGTTCAGGTGGTTTGCTCGTAATGGATGAGGATACTTG
TATGGTAGACGTAGCCAAGTTTTTCTTGGACTTTACTGCTGAAGAGTCCTGCGGTAAATGTACTTTCTGCCGAATCGGAA
CTCATCAGATGCTTGATATTTTAGATAAAATCACTGAAGGTCGAGGAGAAATGGAAGACATTGATCGTTTAGAAGATTTG
GGTAGTAAAATCATTAAAGGATCCCTATGTGGATTGGGTCAAACTGCTCCTAACCCGGTATTAACAACCTTGAAGTACTT
TAGAGATGAGTACGAAGCTCATGTTAAAGAAAATAGATGTCCAGCTGGCACTTGTAAAGAGCTGATCGCCTTCTCCATAA
CAGATGATTGTATTGGTTGCGGAGTTTGTAAGAAGAGCTGTCCAGTTGGAGCGATTTCTGGAGATAAAAAAGAGATCCAT
ATCATAGATCAAGAAGAATGTGTAAAATGCGGTATGTGCGTATCAGCATGTAAATTTGATGCTATTCACGTAGTTAGTGG
TGAAGAGAAAGAGAGGATAACTAGCAAGGGAGGGGATAAAGGTGACGAAAGTTAA

Upstream 100 bases:

>100_bases
TTTAGCACCAGTTATGACTATAAATGGTGAAACTCACGGCAGGCTGACTCCTGACAAAGCTGTTAAAATAGCTAAAAACA
TCTAGGAGGTGGACAAAAGT

Downstream 100 bases:

>100_bases
AGTAACAATTGATAACAAAACTGTTGAAGTGAATCCAGGAGCGACTGTTTTAGAAGCTGCGGAAAAGGCTGATGTGGAAA
TCCCCACCTTGTGTCATGAT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MVPVVKIGMASCGIAAGAKKVYDLFSDEAQSKASVQETGCVGMCFKEPLVEVIDNEGRFIYGDVDEKKAQQIIEDHLDNG
QPVEDLIVYSDKIESEIQKYLDSQKRILLKNSGKIDPENIESYLEEGGYQGLLNALKEMTPKDVIEEVQSSGLRGRGGAG
FPTFKKWEFTRIEERQPKYVICNADEGDPGAFMDRSVLESDPHSLLEGMAIAGYAIGANTGYIYIRAEYPLAVKRLEIAI
EQAKEKGYLGKNIQDTGFDFDIYIREGAGAFVCGEETALIASIEGKRGTPTFKPPFPAQKGLWTQPSCINNVETLANVPR
VFLQGAEAYSELGTENSKGTKVFALAGDVKRGGLIEVPMGIKIKDIVYEVGGGIVEDKGFKAVQIGGPSGGCIPAKYQDV
SVDYESLNELGAIMGSGGLLVMDEDTCMVDVAKFFLDFTAEESCGKCTFCRIGTHQMLDILDKITEGRGEMEDIDRLEDL
GSKIIKGSLCGLGQTAPNPVLTTLKYFRDEYEAHVKENRCPAGTCKELIAFSITDDCIGCGVCKKSCPVGAISGDKKEIH
IIDQEECVKCGMCVSACKFDAIHVVSGEEKERITSKGGDKGDES

Sequences:

>Translated_604_residues
MVPVVKIGMASCGIAAGAKKVYDLFSDEAQSKASVQETGCVGMCFKEPLVEVIDNEGRFIYGDVDEKKAQQIIEDHLDNG
QPVEDLIVYSDKIESEIQKYLDSQKRILLKNSGKIDPENIESYLEEGGYQGLLNALKEMTPKDVIEEVQSSGLRGRGGAG
FPTFKKWEFTRIEERQPKYVICNADEGDPGAFMDRSVLESDPHSLLEGMAIAGYAIGANTGYIYIRAEYPLAVKRLEIAI
EQAKEKGYLGKNIQDTGFDFDIYIREGAGAFVCGEETALIASIEGKRGTPTFKPPFPAQKGLWTQPSCINNVETLANVPR
VFLQGAEAYSELGTENSKGTKVFALAGDVKRGGLIEVPMGIKIKDIVYEVGGGIVEDKGFKAVQIGGPSGGCIPAKYQDV
SVDYESLNELGAIMGSGGLLVMDEDTCMVDVAKFFLDFTAEESCGKCTFCRIGTHQMLDILDKITEGRGEMEDIDRLEDL
GSKIIKGSLCGLGQTAPNPVLTTLKYFRDEYEAHVKENRCPAGTCKELIAFSITDDCIGCGVCKKSCPVGAISGDKKEIH
IIDQEECVKCGMCVSACKFDAIHVVSGEEKERITSKGGDKGDES
>Mature_604_residues
MVPVVKIGMASCGIAAGAKKVYDLFSDEAQSKASVQETGCVGMCFKEPLVEVIDNEGRFIYGDVDEKKAQQIIEDHLDNG
QPVEDLIVYSDKIESEIQKYLDSQKRILLKNSGKIDPENIESYLEEGGYQGLLNALKEMTPKDVIEEVQSSGLRGRGGAG
FPTFKKWEFTRIEERQPKYVICNADEGDPGAFMDRSVLESDPHSLLEGMAIAGYAIGANTGYIYIRAEYPLAVKRLEIAI
EQAKEKGYLGKNIQDTGFDFDIYIREGAGAFVCGEETALIASIEGKRGTPTFKPPFPAQKGLWTQPSCINNVETLANVPR
VFLQGAEAYSELGTENSKGTKVFALAGDVKRGGLIEVPMGIKIKDIVYEVGGGIVEDKGFKAVQIGGPSGGCIPAKYQDV
SVDYESLNELGAIMGSGGLLVMDEDTCMVDVAKFFLDFTAEESCGKCTFCRIGTHQMLDILDKITEGRGEMEDIDRLEDL
GSKIIKGSLCGLGQTAPNPVLTTLKYFRDEYEAHVKENRCPAGTCKELIAFSITDDCIGCGVCKKSCPVGAISGDKKEIH
IIDQEECVKCGMCVSACKFDAIHVVSGEEKERITSKGGDKGDES

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=380, Percent_Identity=39.4736842105263, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI20149568, Length=420, Percent_Identity=37.6190476190476, Blast_Score=291, Evalue=2e-78,
Organism=Escherichia coli, GI1788620, Length=403, Percent_Identity=40.4466501240695, Blast_Score=328, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=377, Percent_Identity=38.7267904509284, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI45550452, Length=379, Percent_Identity=39.8416886543536, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI19920794, Length=376, Percent_Identity=39.0957446808511, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=32.7272727272727, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24653817, Length=357, Percent_Identity=31.0924369747899, Blast_Score=192, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 65590; Mature: 65590

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPVVKIGMASCGIAAGAKKVYDLFSDEAQSKASVQETGCVGMCFKEPLVEVIDNEGRFI
CCCEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCEE
YGDVDEKKAQQIIEDHLDNGQPVEDLIVYSDKIESEIQKYLDSQKRILLKNSGKIDPENI
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHH
ESYLEEGGYQGLLNALKEMTPKDVIEEVQSSGLRGRGGAGFPTFKKWEFTRIEERQPKYV
HHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCCCCEE
ICNADEGDPGAFMDRSVLESDPHSLLEGMAIAGYAIGANTGYIYIRAEYPLAVKRLEIAI
EEECCCCCCCCHHHHHHHCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHH
EQAKEKGYLGKNIQDTGFDFDIYIREGAGAFVCGEETALIASIEGKRGTPTFKPPFPAQK
HHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
GLWTQPSCINNVETLANVPRVFLQGAEAYSELGTENSKGTKVFALAGDVKRGGLIEVPMG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCC
IKIKDIVYEVGGGIVEDKGFKAVQIGGPSGGCIPAKYQDVSVDYESLNELGAIMGSGGLL
CCHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
VMDEDTCMVDVAKFFLDFTAEESCGKCTFCRIGTHQMLDILDKITEGRGEMEDIDRLEDL
EEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHH
GSKIIKGSLCGLGQTAPNPVLTTLKYFRDEYEAHVKENRCPAGTCKELIAFSITDDCIGC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECCHHHHHC
GVCKKSCPVGAISGDKKEIHIIDQEECVKCGMCVSACKFDAIHVVSGEEKERITSKGGDK
CCHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCC
GDES
CCCC
>Mature Secondary Structure
MVPVVKIGMASCGIAAGAKKVYDLFSDEAQSKASVQETGCVGMCFKEPLVEVIDNEGRFI
CCCEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCEE
YGDVDEKKAQQIIEDHLDNGQPVEDLIVYSDKIESEIQKYLDSQKRILLKNSGKIDPENI
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHH
ESYLEEGGYQGLLNALKEMTPKDVIEEVQSSGLRGRGGAGFPTFKKWEFTRIEERQPKYV
HHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCCCCEE
ICNADEGDPGAFMDRSVLESDPHSLLEGMAIAGYAIGANTGYIYIRAEYPLAVKRLEIAI
EEECCCCCCCCHHHHHHHCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHH
EQAKEKGYLGKNIQDTGFDFDIYIREGAGAFVCGEETALIASIEGKRGTPTFKPPFPAQK
HHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
GLWTQPSCINNVETLANVPRVFLQGAEAYSELGTENSKGTKVFALAGDVKRGGLIEVPMG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCC
IKIKDIVYEVGGGIVEDKGFKAVQIGGPSGGCIPAKYQDVSVDYESLNELGAIMGSGGLL
CCHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
VMDEDTCMVDVAKFFLDFTAEESCGKCTFCRIGTHQMLDILDKITEGRGEMEDIDRLEDL
EEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHH
GSKIIKGSLCGLGQTAPNPVLTTLKYFRDEYEAHVKENRCPAGTCKELIAFSITDDCIGC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECCHHHHHC
GVCKKSCPVGAISGDKKEIHIIDQEECVKCGMCVSACKFDAIHVVSGEEKERITSKGGDK
CCHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCC
GDES
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]