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The map label for this gene is ahcY [H]

Identifier: 188585726

GI number: 188585726

Start: 1160848

End: 1162107

Strand: Direct

Name: ahcY [H]

Synonym: Nther_1099

Alternate gene names: 188585726

Gene position: 1160848-1162107 (Clockwise)

Preceding gene: 188585724

Following gene: 188585727

Centisome position: 36.67

GC content: 39.44

Gene sequence:

>1260_bases
ATGGATATGACAGAAAAGATTAACACTGAGTTAGTGGAGCAGGGGAAAAACAAAATAATGTGGGCAAGAAACAAAATGCC
AGTTATCAGAAATATTTCCGAGCGCTGGAAACGTGAACAACCCCTGGCCGGGATCAGGGTAGCAGCGTGTTTACACGTGA
CCTCAAAAACTGCGAATTTATTAATAACTTTGAAGGATGGTGGGGCTGAAGTAGCCCTTTGTGGCTCAAATCCCTTAAGT
ACACAAGATGACGTGGTAGCGGCTTTGAATGAAGTTTATGATGTCCCAACTCATGCCAAACGAGGAGAAGACAAAGATTC
CTTTTATAATCGTATTTTAACCGTATTAGACTTGCAACCTCATATCACAGTAGATGATGGTGCTGATTTAATCACTACAT
TACATAGCCAGAGAAAAGAATTACTGGATTCAGTACTGGGCGGTACCGAAGAGACTACTACAGGTGTTACACGTTTAAAA
GCAATGGCCAAAGATAATTATTTAAAGTATCCTGTGATTGCTGTTAATGATGCCATGACTAAACATATGTTTGACAACCG
TTATGGTACAGGCCAGTCAACTATTGATGGTATTATGAGAGCTACGAATTATTTATTGGCAGGGGCTCATTTTGTAGTAG
TCGGTTATGGTTGGTGCGGACGAGGTATTGCAAAAGATGCTAGCGGCATGGGTGCTCGGGTAACAGTGGTGGAAGTAGAT
TCAGTCAGAGCTTTAGAAGCTGCTTTAGATGGTTTCGAAGTTTCTAGTATGGATGAAGCTGCGGAAAAAGCAGATTTTAT
AGTGACAACAACGGGGAATAAAAATGTGGTTGATAAGAAACATTTAGACAAGATCAATGATGGTTGTATATTATCTAATG
CCGGTCACTTTAATGTAGAAATTAATTTGCAGGCCTTAGAGGAAATGACTAAGGAACAGCGAGAAGTTCGTCCTGATGTG
CAAGAGTATTCCTTCAAAGATGGGCGAAAGGTATATTTGATTGGGGAAGGTAGATTGGTAAATCTAACTGCTGGTGAAGG
ACATCCGGCTGATGTCATGGATATGAGTTTTTCTAATCAAGCCTTATCTGTAGAATATTTAGCCAAAGAACATGAACAAT
TAGCTAAAGATGTTTATCCAGTTCCACGGCATTTAGATGAGAGTATTGCTAAGTTAAAACTTAAGTCAATGGGAATGGAG
CTTGAACAGTTAACTGATGAACAAATTGATTATCTTAACTCTTGGGAAATAGGTACTTAA

Upstream 100 bases:

>100_bases
GAAGGGGAAAATATGTAATAAAGTTTATCGTTGAGTCATTTATTATTATAGAGGAGAATTTGGTCAAGTAATGGAATATT
TATAAAAAAGGGAGGTTTTG

Downstream 100 bases:

>100_bases
TAAGCTAGCTGTTACGGATGAGTAGGGAGTGGATTTTTCATGAAAGAATGGAATAAAATATTTTATATTTTTGTTGCAGT
ATTTGGCTTGATAGCTTTTG

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MDMTEKINTELVEQGKNKIMWARNKMPVIRNISERWKREQPLAGIRVAACLHVTSKTANLLITLKDGGAEVALCGSNPLS
TQDDVVAALNEVYDVPTHAKRGEDKDSFYNRILTVLDLQPHITVDDGADLITTLHSQRKELLDSVLGGTEETTTGVTRLK
AMAKDNYLKYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLLAGAHFVVVGYGWCGRGIAKDASGMGARVTVVEVD
SVRALEAALDGFEVSSMDEAAEKADFIVTTTGNKNVVDKKHLDKINDGCILSNAGHFNVEINLQALEEMTKEQREVRPDV
QEYSFKDGRKVYLIGEGRLVNLTAGEGHPADVMDMSFSNQALSVEYLAKEHEQLAKDVYPVPRHLDESIAKLKLKSMGME
LEQLTDEQIDYLNSWEIGT

Sequences:

>Translated_419_residues
MDMTEKINTELVEQGKNKIMWARNKMPVIRNISERWKREQPLAGIRVAACLHVTSKTANLLITLKDGGAEVALCGSNPLS
TQDDVVAALNEVYDVPTHAKRGEDKDSFYNRILTVLDLQPHITVDDGADLITTLHSQRKELLDSVLGGTEETTTGVTRLK
AMAKDNYLKYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLLAGAHFVVVGYGWCGRGIAKDASGMGARVTVVEVD
SVRALEAALDGFEVSSMDEAAEKADFIVTTTGNKNVVDKKHLDKINDGCILSNAGHFNVEINLQALEEMTKEQREVRPDV
QEYSFKDGRKVYLIGEGRLVNLTAGEGHPADVMDMSFSNQALSVEYLAKEHEQLAKDVYPVPRHLDESIAKLKLKSMGME
LEQLTDEQIDYLNSWEIGT
>Mature_419_residues
MDMTEKINTELVEQGKNKIMWARNKMPVIRNISERWKREQPLAGIRVAACLHVTSKTANLLITLKDGGAEVALCGSNPLS
TQDDVVAALNEVYDVPTHAKRGEDKDSFYNRILTVLDLQPHITVDDGADLITTLHSQRKELLDSVLGGTEETTTGVTRLK
AMAKDNYLKYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLLAGAHFVVVGYGWCGRGIAKDASGMGARVTVVEVD
SVRALEAALDGFEVSSMDEAAEKADFIVTTTGNKNVVDKKHLDKINDGCILSNAGHFNVEINLQALEEMTKEQREVRPDV
QEYSFKDGRKVYLIGEGRLVNLTAGEGHPADVMDMSFSNQALSVEYLAKEHEQLAKDVYPVPRHLDESIAKLKLKSMGME
LEQLTDEQIDYLNSWEIGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=405, Percent_Identity=40, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=40.5128205128205, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI298286489, Length=409, Percent_Identity=36.1858190709046, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI195539349, Length=409, Percent_Identity=36.1858190709046, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI24308043, Length=409, Percent_Identity=36.1858190709046, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI195539337, Length=409, Percent_Identity=36.1858190709046, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI21361647, Length=409, Percent_Identity=35.6968215158924, Blast_Score=256, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17506425, Length=412, Percent_Identity=41.2621359223301, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6320882, Length=430, Percent_Identity=38.6046511627907, Blast_Score=282, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24642172, Length=412, Percent_Identity=40.2912621359223, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=35.5721393034826, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI45553385, Length=401, Percent_Identity=36.6583541147132, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI45553387, Length=401, Percent_Identity=36.6583541147132, Blast_Score=245, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46379; Mature: 46379

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTEKINTELVEQGKNKIMWARNKMPVIRNISERWKREQPLAGIRVAACLHVTSKTANL
CCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCEE
LITLKDGGAEVALCGSNPLSTQDDVVAALNEVYDVPTHAKRGEDKDSFYNRILTVLDLQP
EEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEECCC
HITVDDGADLITTLHSQRKELLDSVLGGTEETTTGVTRLKAMAKDNYLKYPVIAVNDAMT
CEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCEEEECHHHH
KHMFDNRYGTGQSTIDGIMRATNYLLAGAHFVVVGYGWCGRGIAKDASGMGARVTVVEVD
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEC
SVRALEAALDGFEVSSMDEAAEKADFIVTTTGNKNVVDKKHLDKINDGCILSNAGHFNVE
CHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCEEEECCCEEEEE
INLQALEEMTKEQREVRPDVQEYSFKDGRKVYLIGEGRLVNLTAGEGHPADVMDMSFSNQ
EEHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCEECCCCCC
ALSVEYLAKEHEQLAKDVYPVPRHLDESIAKLKLKSMGMELEQLTDEQIDYLNSWEIGT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCC
>Mature Secondary Structure
MDMTEKINTELVEQGKNKIMWARNKMPVIRNISERWKREQPLAGIRVAACLHVTSKTANL
CCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCEE
LITLKDGGAEVALCGSNPLSTQDDVVAALNEVYDVPTHAKRGEDKDSFYNRILTVLDLQP
EEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEECCC
HITVDDGADLITTLHSQRKELLDSVLGGTEETTTGVTRLKAMAKDNYLKYPVIAVNDAMT
CEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCEEEECHHHH
KHMFDNRYGTGQSTIDGIMRATNYLLAGAHFVVVGYGWCGRGIAKDASGMGARVTVVEVD
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEC
SVRALEAALDGFEVSSMDEAAEKADFIVTTTGNKNVVDKKHLDKINDGCILSNAGHFNVE
CHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCEEEECCCEEEEE
INLQALEEMTKEQREVRPDVQEYSFKDGRKVYLIGEGRLVNLTAGEGHPADVMDMSFSNQ
EEHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCEECCCCCC
ALSVEYLAKEHEQLAKDVYPVPRHLDESIAKLKLKSMGMELEQLTDEQIDYLNSWEIGT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]