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The map label for this gene is uraA [H]

Identifier: 188585716

GI number: 188585716

Start: 1150095

End: 1151387

Strand: Reverse

Name: uraA [H]

Synonym: Nther_1089

Alternate gene names: 188585716

Gene position: 1151387-1150095 (Counterclockwise)

Preceding gene: 188585717

Following gene: 188585715

Centisome position: 36.37

GC content: 39.29

Gene sequence:

>1293_bases
ATGAAAACTAACACAAACCAATTACTAACCCAACTTCCCATGGCTTTTCAACACGTATTTGCCATGTTTGGGGCTACAGT
TTTAGTCCCTTTCATTACTGGGCTGAACCCCTCTGTAGCTTTGTTTACAGCCGGATTGGGAACTCTCATCTTTCACTTAG
TAACGGGAGGAAAGGTTCCAGTCTTTTTAGGTTCGTCATTTGCTTTTATCGCAGGTATCCAAGCAGTAAACGCTAATTTT
GGACTAGCCCATGCCACTGGGTCTCTGATAGCAGTTGGTGTTGTTTATCTGTTAATAGCGGGAGCTGTAGTATTAATTGG
AATAAATAATATCAGGCGTCTTTTTCCTCCAATAGTTACTGGCCCAATTATCATAGTAATAGGTCTTATCCTAGCACCTA
ATGCCATAGAAATGGCTGCAGAACATTGGGGTATCGCACTCATTACAATAGTGGCAGTATTAACTACAGGGATTATGGGA
AAAGGATTTTTAAAGATAATCCCCATCTTAATTGGAATCACCACAGGTTACGTAGCTAGTGTTTTGTTCGGAATAATTGA
TTTTGATCCTATCCGAGATGCAGCTTGGTTGAGATTTCCTGAATTCATGGCTCCTGAGTTTTCCATGGATGCGTTAAAAA
TTATGATCCCTATTGCATTGGTAACCGTTATTGAGCATATTGGGGACATTACCACCAACGGTGCTGTAGTAGGTAAAGAC
TTTTTTAAAAATCCTGGCCTACACAAGACATTAATCGGTGACGGAATTGCTACAATCGTAGGTGGTGCCTTAGGAGGACC
TCCTAACACCACATACGGTGAAAATACAGGAGTATTAGCCCTAACAAAAAACTATAACCCAGCCATCATAAGAATAGCGG
CAGTACTAGCCATTGGTTTCAGTTTTATTGGTAAACTTGGAGCATTCATCATGACTATCCCAGAACCAGTAATGGGCGGA
GTTAGCTTCGTACTTTTCGGCATGATTGCCAGCGTTGGAGTTAGAACATTAGTTGATTCAGGTCCTGATCTGTCTAATTT
GAGAAACTCAAGTGTAGTATTCATAATATTAATAGTAGGAATCTCATATTTACAAGGAGAAGAAAATCTTGCAACTATTC
AATTGACAGAATACGCTAGTCTTGAAGGGTTAAGTTTAGCTGCCCTGCTAGGGATATCATTAAATGCAGTTTTCGAATTT
ATTTTGCCCAAAATATCAGCAATTGAAAATATTATCCCTTCAAATGAAGGGTATAACTCCACTGAAAAAGTGGCTCCAAA
TAAATCAAAATAA

Upstream 100 bases:

>100_bases
CATCCATTTCAATAACTATTAACAAGATTTCATGAACCAAATCCTGCAGCTGTAACACTATCCTAAAGGCCAAAAAATTC
TATGAAGGAGGAACTTGCTA

Downstream 100 bases:

>100_bases
TGTCAGAAATAAATTCTCTTTGTTAAGGGCTCCTATATAGGAGCCCTTATTTTTTGTTGTTCATGAAAACAAAAGTTTTA
TGTTTTATGGTTTATAAATG

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKTNTNQLLTQLPMAFQHVFAMFGATVLVPFITGLNPSVALFTAGLGTLIFHLVTGGKVPVFLGSSFAFIAGIQAVNANF
GLAHATGSLIAVGVVYLLIAGAVVLIGINNIRRLFPPIVTGPIIIVIGLILAPNAIEMAAEHWGIALITIVAVLTTGIMG
KGFLKIIPILIGITTGYVASVLFGIIDFDPIRDAAWLRFPEFMAPEFSMDALKIMIPIALVTVIEHIGDITTNGAVVGKD
FFKNPGLHKTLIGDGIATIVGGALGGPPNTTYGENTGVLALTKNYNPAIIRIAAVLAIGFSFIGKLGAFIMTIPEPVMGG
VSFVLFGMIASVGVRTLVDSGPDLSNLRNSSVVFIILIVGISYLQGEENLATIQLTEYASLEGLSLAALLGISLNAVFEF
ILPKISAIENIIPSNEGYNSTEKVAPNKSK

Sequences:

>Translated_430_residues
MKTNTNQLLTQLPMAFQHVFAMFGATVLVPFITGLNPSVALFTAGLGTLIFHLVTGGKVPVFLGSSFAFIAGIQAVNANF
GLAHATGSLIAVGVVYLLIAGAVVLIGINNIRRLFPPIVTGPIIIVIGLILAPNAIEMAAEHWGIALITIVAVLTTGIMG
KGFLKIIPILIGITTGYVASVLFGIIDFDPIRDAAWLRFPEFMAPEFSMDALKIMIPIALVTVIEHIGDITTNGAVVGKD
FFKNPGLHKTLIGDGIATIVGGALGGPPNTTYGENTGVLALTKNYNPAIIRIAAVLAIGFSFIGKLGAFIMTIPEPVMGG
VSFVLFGMIASVGVRTLVDSGPDLSNLRNSSVVFIILIVGISYLQGEENLATIQLTEYASLEGLSLAALLGISLNAVFEF
ILPKISAIENIIPSNEGYNSTEKVAPNKSK
>Mature_430_residues
MKTNTNQLLTQLPMAFQHVFAMFGATVLVPFITGLNPSVALFTAGLGTLIFHLVTGGKVPVFLGSSFAFIAGIQAVNANF
GLAHATGSLIAVGVVYLLIAGAVVLIGINNIRRLFPPIVTGPIIIVIGLILAPNAIEMAAEHWGIALITIVAVLTTGIMG
KGFLKIIPILIGITTGYVASVLFGIIDFDPIRDAAWLRFPEFMAPEFSMDALKIMIPIALVTVIEHIGDITTNGAVVGKD
FFKNPGLHKTLIGDGIATIVGGALGGPPNTTYGENTGVLALTKNYNPAIIRIAAVLAIGFSFIGKLGAFIMTIPEPVMGG
VSFVLFGMIASVGVRTLVDSGPDLSNLRNSSVVFIILIVGISYLQGEENLATIQLTEYASLEGLSLAALLGISLNAVFEF
ILPKISAIENIIPSNEGYNSTEKVAPNKSK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=437, Percent_Identity=23.7986270022883, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI40316845, Length=437, Percent_Identity=23.7986270022883, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI44680143, Length=421, Percent_Identity=24.4655581947743, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI44680145, Length=417, Percent_Identity=24.4604316546763, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1788843, Length=427, Percent_Identity=39.344262295082, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI87081818, Length=369, Percent_Identity=37.6693766937669, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87082181, Length=418, Percent_Identity=26.555023923445, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082178, Length=238, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790087, Length=397, Percent_Identity=23.9294710327456, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=369, Percent_Identity=24.1192411924119, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=383, Percent_Identity=22.1932114882507, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356175, Length=413, Percent_Identity=25.4237288135593, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45081; Mature: 45081

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNTNQLLTQLPMAFQHVFAMFGATVLVPFITGLNPSVALFTAGLGTLIFHLVTGGKVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEE
VFLGSSFAFIAGIQAVNANFGLAHATGSLIAVGVVYLLIAGAVVLIGINNIRRLFPPIVT
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GPIIIVIGLILAPNAIEMAAEHWGIALITIVAVLTTGIMGKGFLKIIPILIGITTGYVAS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VLFGIIDFDPIRDAAWLRFPEFMAPEFSMDALKIMIPIALVTVIEHIGDITTNGAVVGKD
HHHHHHCCCCCCCHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHH
FFKNPGLHKTLIGDGIATIVGGALGGPPNTTYGENTGVLALTKNYNPAIIRIAAVLAIGF
HHCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
SFIGKLGAFIMTIPEPVMGGVSFVLFGMIASVGVRTLVDSGPDLSNLRNSSVVFIILIVG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEHHHHHH
ISYLQGEENLATIQLTEYASLEGLSLAALLGISLNAVFEFILPKISAIENIIPSNEGYNS
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TEKVAPNKSK
HHCCCCCCCC
>Mature Secondary Structure
MKTNTNQLLTQLPMAFQHVFAMFGATVLVPFITGLNPSVALFTAGLGTLIFHLVTGGKVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEE
VFLGSSFAFIAGIQAVNANFGLAHATGSLIAVGVVYLLIAGAVVLIGINNIRRLFPPIVT
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GPIIIVIGLILAPNAIEMAAEHWGIALITIVAVLTTGIMGKGFLKIIPILIGITTGYVAS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VLFGIIDFDPIRDAAWLRFPEFMAPEFSMDALKIMIPIALVTVIEHIGDITTNGAVVGKD
HHHHHHCCCCCCCHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHH
FFKNPGLHKTLIGDGIATIVGGALGGPPNTTYGENTGVLALTKNYNPAIIRIAAVLAIGF
HHCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
SFIGKLGAFIMTIPEPVMGGVSFVLFGMIASVGVRTLVDSGPDLSNLRNSSVVFIILIVG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEHHHHHH
ISYLQGEENLATIQLTEYASLEGLSLAALLGISLNAVFEFILPKISAIENIIPSNEGYNS
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TEKVAPNKSK
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]