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The map label for this gene is tlpC [H]

Identifier: 188585635

GI number: 188585635

Start: 1073900

End: 1075624

Strand: Direct

Name: tlpC [H]

Synonym: Nther_1008

Alternate gene names: 188585635

Gene position: 1073900-1075624 (Clockwise)

Preceding gene: 188585634

Following gene: 188585636

Centisome position: 33.92

GC content: 35.94

Gene sequence:

>1725_bases
ATGTTGAATAATATGGGAATTAAGCCGAAGTTAATGTTGTTTATAGTGCTCATAATTGTGATCGCCACTGCTTGTTTTTG
GGTTTTAAATAATTATACAGTAAACAATATAGTTGATGAAAGGGCAGCAAACCAACTGGATTCAGAACATAGCATGAGTA
TGAGACTAATAGATGAACATTCTACTGGGGCTTGGACGCTAATGGAAAGGGAAGATCGGACCTATATGTATAAAGGCGGT
ACTCCCGTCCACACACTTGATGATGTACTTGATGAATTTCATGAAAAGACTGGTTCCGCTTTTGCAGTTTTCAGACGTGA
TACCATAGAAGCTACTACTATAGAGGGAGATGATGGTGAAAGAATCATAGGGGCTCAGGCTGAGGAAAGAATTGCTGAAA
CAGTATTAGAAGAAGGGGAAAACTATTCCGGAGAAGTTGAAATTGCAGGAACTTCTTATGAGGCTCGATATGCTCCCCTT
GAGGATGAAGATGGTAATATAGTCGGTATGTGGTTAGTAGGAACACCTGTAGAAGAAATAAATCAAATGGTTAGTCAAGC
AGGTCTGAATTTTCTCATGTTTTCTGGATTAATAATTATTATTTCCTTAATTATTACTCACTTTATAACAAATAATTTTA
CCAAACCTATTAAAAATTTAACATCAAATATAAGTAAATTAGCTGATTATGACTTTACTTTTGATGAGGATAGTGTTACA
AATAACTATCTAAACAGAAAAGATGAGATAGGTATCATTACTAATGCTTTGACTAATATGCAAACAAATATTATTTCGTT
AATAAAAAATATCAATGAAAAGTCGGAACAAGTTGCTTCATCAGCTGAAGAAATGAGTGCCAACAGTGAAGAAAACACCA
ATGCTGCCAATGAAGTGTCCCGAGCTGTAGAAGATATAGCAAGCGGTGCAACAAATCAAGCTGAAAAAACTGAGCAAACT
TCAGAAAACATTAATAAGCTGGGAGAAATTATTGAAAATGACCAAAAACAGGTTATGGAGTTAAGTGATGTTACTGAAGA
TGTTGATAAATTACGTGAAGAAGGAAGTACTACAGTTTCTGATTTAGCAGATAAAGCAGTAGAGAGTAATCAAGCAGCTG
AAGAGATATTTAATACTGTTAAGGAAACAAAAAACAGTGCTAAAGAGATTGAACAGGCCAGTAGTACAATTCAGGACATT
GCAGAACAGACTAATTTACTAGCTCTAAATGCAAGTATTGAAGCGGCTAGAGCTGGAGAGTCAGGCTCAGGATTTGCCGT
TGTAGCCGATGAAATACGCCAGTTAGCCGAACGATCTAATGAACACTCAGAGGAAATTTCCAAAATAGTACGCGATCTAA
ATAAAAAGTCCGATAATGCAGTGAGTACAATGGAGACTCTTGAAGAGGTTGTGAAAGCACAAACTGAAGGTGTTGAAAAT
ACTAAAGAAAAGTTCCAAGGAATTTCTCAAGGGATACAGAAGATTAAAGAAAATGTAGAATCGCTACGAGAATCCAGTGA
AGAAATGAGAGCTAAAAAGGAAGAAATTACAACTGCTTTACAAGAGTTGTCTGCCATAGCTGAAGAGAATTCATCAAGCA
CTCAGGAAATTTCATCATCAGTAGAAGAACAAACTGCTTCTATGGATGAAATAGCTAAAGCCAGTGATAGTTTGGCACAG
TTAGCTGAGGAAATGCAGCAACAGGTATCTAAATTTAAATATTAA

Upstream 100 bases:

>100_bases
AGTATTCGATCATTTTCCTGATAAGGAGGTGGAATCCTATTTAGACCTCTGGGCAGAGTGAAGAAAGGGTTTGATATGTT
AGTTAAAGGGGAGGTTTTAC

Downstream 100 bases:

>100_bases
TGTTAACCTTTAAATTATTGATTCTTTGATGATTCTCTAATATAGTAGAAATCCGTAGATGATCCCTGCACTTTAATTTT
AGAGTGCAGGGATTTTTATT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MLNNMGIKPKLMLFIVLIIVIATACFWVLNNYTVNNIVDERAANQLDSEHSMSMRLIDEHSTGAWTLMEREDRTYMYKGG
TPVHTLDDVLDEFHEKTGSAFAVFRRDTIEATTIEGDDGERIIGAQAEERIAETVLEEGENYSGEVEIAGTSYEARYAPL
EDEDGNIVGMWLVGTPVEEINQMVSQAGLNFLMFSGLIIIISLIITHFITNNFTKPIKNLTSNISKLADYDFTFDEDSVT
NNYLNRKDEIGIITNALTNMQTNIISLIKNINEKSEQVASSAEEMSANSEENTNAANEVSRAVEDIASGATNQAEKTEQT
SENINKLGEIIENDQKQVMELSDVTEDVDKLREEGSTTVSDLADKAVESNQAAEEIFNTVKETKNSAKEIEQASSTIQDI
AEQTNLLALNASIEAARAGESGSGFAVVADEIRQLAERSNEHSEEISKIVRDLNKKSDNAVSTMETLEEVVKAQTEGVEN
TKEKFQGISQGIQKIKENVESLRESSEEMRAKKEEITTALQELSAIAEENSSSTQEISSSVEEQTASMDEIAKASDSLAQ
LAEEMQQQVSKFKY

Sequences:

>Translated_574_residues
MLNNMGIKPKLMLFIVLIIVIATACFWVLNNYTVNNIVDERAANQLDSEHSMSMRLIDEHSTGAWTLMEREDRTYMYKGG
TPVHTLDDVLDEFHEKTGSAFAVFRRDTIEATTIEGDDGERIIGAQAEERIAETVLEEGENYSGEVEIAGTSYEARYAPL
EDEDGNIVGMWLVGTPVEEINQMVSQAGLNFLMFSGLIIIISLIITHFITNNFTKPIKNLTSNISKLADYDFTFDEDSVT
NNYLNRKDEIGIITNALTNMQTNIISLIKNINEKSEQVASSAEEMSANSEENTNAANEVSRAVEDIASGATNQAEKTEQT
SENINKLGEIIENDQKQVMELSDVTEDVDKLREEGSTTVSDLADKAVESNQAAEEIFNTVKETKNSAKEIEQASSTIQDI
AEQTNLLALNASIEAARAGESGSGFAVVADEIRQLAERSNEHSEEISKIVRDLNKKSDNAVSTMETLEEVVKAQTEGVEN
TKEKFQGISQGIQKIKENVESLRESSEEMRAKKEEITTALQELSAIAEENSSSTQEISSSVEEQTASMDEIAKASDSLAQ
LAEEMQQQVSKFKY
>Mature_574_residues
MLNNMGIKPKLMLFIVLIIVIATACFWVLNNYTVNNIVDERAANQLDSEHSMSMRLIDEHSTGAWTLMEREDRTYMYKGG
TPVHTLDDVLDEFHEKTGSAFAVFRRDTIEATTIEGDDGERIIGAQAEERIAETVLEEGENYSGEVEIAGTSYEARYAPL
EDEDGNIVGMWLVGTPVEEINQMVSQAGLNFLMFSGLIIIISLIITHFITNNFTKPIKNLTSNISKLADYDFTFDEDSVT
NNYLNRKDEIGIITNALTNMQTNIISLIKNINEKSEQVASSAEEMSANSEENTNAANEVSRAVEDIASGATNQAEKTEQT
SENINKLGEIIENDQKQVMELSDVTEDVDKLREEGSTTVSDLADKAVESNQAAEEIFNTVKETKNSAKEIEQASSTIQDI
AEQTNLLALNASIEAARAGESGSGFAVVADEIRQLAERSNEHSEEISKIVRDLNKKSDNAVSTMETLEEVVKAQTEGVEN
TKEKFQGISQGIQKIKENVESLRESSEEMRAKKEEITTALQELSAIAEENSSSTQEISSSVEEQTASMDEIAKASDSLAQ
LAEEMQQQVSKFKY

Specific function: Mediates Taxis To The Sugars Ribose And Galactose VIa An Interaction With The Periplasmic Ribose- Or Galactose-Binding Proteins. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of Attractants And Repellents In The Environment, Trans

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=382, Percent_Identity=25.9162303664921, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789453, Length=384, Percent_Identity=27.0833333333333, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788195, Length=289, Percent_Identity=26.2975778546713, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI2367378, Length=292, Percent_Identity=25.3424657534247, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788194, Length=378, Percent_Identity=23.015873015873, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 63497; Mature: 63497

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNNMGIKPKLMLFIVLIIVIATACFWVLNNYTVNNIVDERAANQLDSEHSMSMRLIDEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCHHHHHCCC
STGAWTLMEREDRTYMYKGGTPVHTLDDVLDEFHEKTGSAFAVFRRDTIEATTIEGDDGE
CCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCC
RIIGAQAEERIAETVLEEGENYSGEVEIAGTSYEARYAPLEDEDGNIVGMWLVGTPVEEI
EEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCHHHH
NQMVSQAGLNFLMFSGLIIIISLIITHFITNNFTKPIKNLTSNISKLADYDFTFDEDSVT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
NNYLNRKDEIGIITNALTNMQTNIISLIKNINEKSEQVASSAEEMSANSEENTNAANEVS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RAVEDIASGATNQAEKTEQTSENINKLGEIIENDQKQVMELSDVTEDVDKLREEGSTTVS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DLADKAVESNQAAEEIFNTVKETKNSAKEIEQASSTIQDIAEQTNLLALNASIEAARAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCC
SGSGFAVVADEIRQLAERSNEHSEEISKIVRDLNKKSDNAVSTMETLEEVVKAQTEGVEN
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHH
TKEKFQGISQGIQKIKENVESLRESSEEMRAKKEEITTALQELSAIAEENSSSTQEISSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VEEQTASMDEIAKASDSLAQLAEEMQQQVSKFKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNNMGIKPKLMLFIVLIIVIATACFWVLNNYTVNNIVDERAANQLDSEHSMSMRLIDEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCHHHHHCCC
STGAWTLMEREDRTYMYKGGTPVHTLDDVLDEFHEKTGSAFAVFRRDTIEATTIEGDDGE
CCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCC
RIIGAQAEERIAETVLEEGENYSGEVEIAGTSYEARYAPLEDEDGNIVGMWLVGTPVEEI
EEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCHHHH
NQMVSQAGLNFLMFSGLIIIISLIITHFITNNFTKPIKNLTSNISKLADYDFTFDEDSVT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
NNYLNRKDEIGIITNALTNMQTNIISLIKNINEKSEQVASSAEEMSANSEENTNAANEVS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RAVEDIASGATNQAEKTEQTSENINKLGEIIENDQKQVMELSDVTEDVDKLREEGSTTVS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DLADKAVESNQAAEEIFNTVKETKNSAKEIEQASSTIQDIAEQTNLLALNASIEAARAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCC
SGSGFAVVADEIRQLAERSNEHSEEISKIVRDLNKKSDNAVSTMETLEEVVKAQTEGVEN
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHH
TKEKFQGISQGIQKIKENVESLRESSEEMRAKKEEITTALQELSAIAEENSSSTQEISSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VEEQTASMDEIAKASDSLAQLAEEMQQQVSKFKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]