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The map label for this gene is betT [C]

Identifier: 188585630

GI number: 188585630

Start: 1065800

End: 1067461

Strand: Direct

Name: betT [C]

Synonym: Nther_1003

Alternate gene names: 188585630

Gene position: 1065800-1067461 (Clockwise)

Preceding gene: 188585628

Following gene: 188585634

Centisome position: 33.67

GC content: 33.75

Gene sequence:

>1662_bases
ATGGCTGCCAATGATAATAGAAGAAATAGAAATGAGGATCAAGAAATAGATAGAGATAAAATAGAAGAATTATTGTTCAG
TAGAAATACAAAGAAATTTGGTTTTGATTTAAATCCAGTGGTTTCCTTAGGTGCAGGTATAATAATTATAATTTTTTCTG
CTTTTGCTTTGATCAATCTTGAAAGAGCTAATATTTTAGTTAATTCAGTCAATGAAATCATAGTGACAAACTTTGATTGG
ATTTTTATTCTCTCGAGCAGTTTTTTTATTTTGATTTGCATATATATAGCTTTTTCCAAATTAGGTAAAGTCAAAATAGG
TGGATTAAATGCCGAGCGAGAATTTAGTAACTTTGCCTGGTATTCCATGCTAATATCAGCAGGGATGGGTATTGGACTGA
TGTTTTGGGCAGTTGGTGAGCCCTTAACTCATTTTGAAGTTTTACCTCCAGTATTTGATAGCCCTTTCGATAAACATACT
GCCATGGCCACTACTTTTTTTCACTGGGGCTTACACCCTTGGGCAGTTTATTCTTTAATAGCTTTAGCTTTAGCCTTTTT
CGCTTATAATAAGCATTTGCCATTATCAATTAGATCAGTCTTTTATCCTTTTTTTAAAGAAAGAGTGTACGGAACCCTAG
GTGATGTTATCGATACTTTAGCGGTGCTTTCAACTCTGTTTGGATTAGCTACTTCCTTGGGTTTAGGGGCTCAACAAATA
AACAGTGGTCTTGATTATTTATTTGATATTGGTTTTAGTGTTAACATCCAAGTAGCTTTAATAATTGGAATCACATTATT
AGCTACCATTTCCGTATTATCGGGTATAGATAAAGGAGTAAAGTTTCTGTCAAAAATGAATATTAGATTGGCTGCAATTT
TAATGGGAATTATCTTATTATTGGGACCTACTGGTTTTATCTTAAGGCTTTTTTCCAATTCTTTGGGCTTATATTTTAAT
AATATTATTGAATACTCTTTCTTTATTGCAGTAGAAGAAACAGGGTGGCAAGCAAATTGGTCGATCTTTTATTTAGCTTG
GTGGATATCCTGGTCTCCCTTTGTTGGAATGTTTATTGCAAGAATTTCAAAAGGTAGGACCATCAGGGAATTGATCTTAG
GAGTAATGATAGTACCGTCACTGTTATCATTTTTATGGTTATCTGTTTTTGGTGGTAGTGCAATTTTTATTAACGAACAA
GTAGGAGGTTTGTATGAAGTAGTTCAGGATGATTTACCTGTAGCCTTGTATGAGTTGGTTAATTTATTAAATTTACCATT
ATTAGCCGAATTATTTAGAATTTTATTGTTTATATTAATAACTTTCTTAGTGGCAGTATATTTCATAACCTCCTCTGATT
CGGGGTCACTAGTAGTTAATAAAATTACATCAAGTGGTAAACTTAATACTCCGGCAAATCAACGTGCTTTTTGGGCAATT
TTAGAGGGTTTGTTAGCAGCAGTTCTGTTATTGATTGGTGGAGAAAAAGCTTTACTTGCTCTACAGACAGCAGTAATTAG
TACTGGACTTCCATTTGCAGTGGTATTAACCGCCATGGCTTTTGCCTTGATTAAGGGAATTGAAGATACTCGTCGAGAAC
AAAAACGGAAACGGGAGCGGAGAAAATTTGAAAAACTTTTAAAAGCTCACGACCAAGAATAA

Upstream 100 bases:

>100_bases
GATAAAAATAAAAATGATCTAATCTGAATATTATATATATTTGATTTCTCAACGTGCTGTCAAAACGCCTTAATGAAATA
ATGAAAGGGGTCTAAATAAT

Downstream 100 bases:

>100_bases
TATTGCTATTCAAACGGCTAGTCTAGCAATATAAATGAACCTCCCAGAGATTCAATAAACTTTCTGGGAGGTTCTCACTT
CTTCTCTTAGTCCACGTGCT

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MAANDNRRNRNEDQEIDRDKIEELLFSRNTKKFGFDLNPVVSLGAGIIIIIFSAFALINLERANILVNSVNEIIVTNFDW
IFILSSSFFILICIYIAFSKLGKVKIGGLNAEREFSNFAWYSMLISAGMGIGLMFWAVGEPLTHFEVLPPVFDSPFDKHT
AMATTFFHWGLHPWAVYSLIALALAFFAYNKHLPLSIRSVFYPFFKERVYGTLGDVIDTLAVLSTLFGLATSLGLGAQQI
NSGLDYLFDIGFSVNIQVALIIGITLLATISVLSGIDKGVKFLSKMNIRLAAILMGIILLLGPTGFILRLFSNSLGLYFN
NIIEYSFFIAVEETGWQANWSIFYLAWWISWSPFVGMFIARISKGRTIRELILGVMIVPSLLSFLWLSVFGGSAIFINEQ
VGGLYEVVQDDLPVALYELVNLLNLPLLAELFRILLFILITFLVAVYFITSSDSGSLVVNKITSSGKLNTPANQRAFWAI
LEGLLAAVLLLIGGEKALLALQTAVISTGLPFAVVLTAMAFALIKGIEDTRREQKRKRERRKFEKLLKAHDQE

Sequences:

>Translated_553_residues
MAANDNRRNRNEDQEIDRDKIEELLFSRNTKKFGFDLNPVVSLGAGIIIIIFSAFALINLERANILVNSVNEIIVTNFDW
IFILSSSFFILICIYIAFSKLGKVKIGGLNAEREFSNFAWYSMLISAGMGIGLMFWAVGEPLTHFEVLPPVFDSPFDKHT
AMATTFFHWGLHPWAVYSLIALALAFFAYNKHLPLSIRSVFYPFFKERVYGTLGDVIDTLAVLSTLFGLATSLGLGAQQI
NSGLDYLFDIGFSVNIQVALIIGITLLATISVLSGIDKGVKFLSKMNIRLAAILMGIILLLGPTGFILRLFSNSLGLYFN
NIIEYSFFIAVEETGWQANWSIFYLAWWISWSPFVGMFIARISKGRTIRELILGVMIVPSLLSFLWLSVFGGSAIFINEQ
VGGLYEVVQDDLPVALYELVNLLNLPLLAELFRILLFILITFLVAVYFITSSDSGSLVVNKITSSGKLNTPANQRAFWAI
LEGLLAAVLLLIGGEKALLALQTAVISTGLPFAVVLTAMAFALIKGIEDTRREQKRKRERRKFEKLLKAHDQE
>Mature_552_residues
AANDNRRNRNEDQEIDRDKIEELLFSRNTKKFGFDLNPVVSLGAGIIIIIFSAFALINLERANILVNSVNEIIVTNFDWI
FILSSSFFILICIYIAFSKLGKVKIGGLNAEREFSNFAWYSMLISAGMGIGLMFWAVGEPLTHFEVLPPVFDSPFDKHTA
MATTFFHWGLHPWAVYSLIALALAFFAYNKHLPLSIRSVFYPFFKERVYGTLGDVIDTLAVLSTLFGLATSLGLGAQQIN
SGLDYLFDIGFSVNIQVALIIGITLLATISVLSGIDKGVKFLSKMNIRLAAILMGIILLLGPTGFILRLFSNSLGLYFNN
IIEYSFFIAVEETGWQANWSIFYLAWWISWSPFVGMFIARISKGRTIRELILGVMIVPSLLSFLWLSVFGGSAIFINEQV
GGLYEVVQDDLPVALYELVNLLNLPLLAELFRILLFILITFLVAVYFITSSDSGSLVVNKITSSGKLNTPANQRAFWAIL
EGLLAAVLLLIGGEKALLALQTAVISTGLPFAVVLTAMAFALIKGIEDTRREQKRKRERRKFEKLLKAHDQE

Specific function: High-Affinity Uptake Of Choline Driven By A Proton- Motive Force. [C]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=537, Percent_Identity=36.6852886405959, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1786224, Length=521, Percent_Identity=26.1036468330134, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788102, Length=445, Percent_Identity=28.5393258426966, Blast_Score=158, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 61672; Mature: 61541

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANDNRRNRNEDQEIDRDKIEELLFSRNTKKFGFDLNPVVSLGAGIIIIIFSAFALINL
CCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
ERANILVNSVNEIIVTNFDWIFILSSSFFILICIYIAFSKLGKVKIGGLNAEREFSNFAW
HHHHHHHHCCCHHEEECCCEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
YSMLISAGMGIGLMFWAVGEPLTHFEVLPPVFDSPFDKHTAMATTFFHWGLHPWAVYSLI
HHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
ALALAFFAYNKHLPLSIRSVFYPFFKERVYGTLGDVIDTLAVLSTLFGLATSLGLGAQQI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NSGLDYLFDIGFSVNIQVALIIGITLLATISVLSGIDKGVKFLSKMNIRLAAILMGIILL
HCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGPTGFILRLFSNSLGLYFNNIIEYSFFIAVEETGWQANWSIFYLAWWISWSPFVGMFIA
HCCHHHHHHHHHCCHHHHHHHHHHEEEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHH
RISKGRTIRELILGVMIVPSLLSFLWLSVFGGSAIFINEQVGGLYEVVQDDLPVALYELV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCHHHHHHH
NLLNLPLLAELFRILLFILITFLVAVYFITSSDSGSLVVNKITSSGKLNTPANQRAFWAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
LEGLLAAVLLLIGGEKALLALQTAVISTGLPFAVVLTAMAFALIKGIEDTRREQKRKRER
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RKFEKLLKAHDQE
HHHHHHHHHCCCC
>Mature Secondary Structure 
AANDNRRNRNEDQEIDRDKIEELLFSRNTKKFGFDLNPVVSLGAGIIIIIFSAFALINL
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
ERANILVNSVNEIIVTNFDWIFILSSSFFILICIYIAFSKLGKVKIGGLNAEREFSNFAW
HHHHHHHHCCCHHEEECCCEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
YSMLISAGMGIGLMFWAVGEPLTHFEVLPPVFDSPFDKHTAMATTFFHWGLHPWAVYSLI
HHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
ALALAFFAYNKHLPLSIRSVFYPFFKERVYGTLGDVIDTLAVLSTLFGLATSLGLGAQQI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NSGLDYLFDIGFSVNIQVALIIGITLLATISVLSGIDKGVKFLSKMNIRLAAILMGIILL
HCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGPTGFILRLFSNSLGLYFNNIIEYSFFIAVEETGWQANWSIFYLAWWISWSPFVGMFIA
HCCHHHHHHHHHCCHHHHHHHHHHEEEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHH
RISKGRTIRELILGVMIVPSLLSFLWLSVFGGSAIFINEQVGGLYEVVQDDLPVALYELV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCHHHHHHH
NLLNLPLLAELFRILLFILITFLVAVYFITSSDSGSLVVNKITSSGKLNTPANQRAFWAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
LEGLLAAVLLLIGGEKALLALQTAVISTGLPFAVVLTAMAFALIKGIEDTRREQKRKRER
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RKFEKLLKAHDQE
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]