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The map label for this gene is accD

Identifier: 188585474

GI number: 188585474

Start: 891494

End: 893311

Strand: Direct

Name: accD

Synonym: Nther_0846

Alternate gene names: 188585474

Gene position: 891494-893311 (Clockwise)

Preceding gene: 188585473

Following gene: 188585475

Centisome position: 28.16

GC content: 36.08

Gene sequence:

>1818_bases
GTGTTTAAAGGACTATTTAAAAAAACAAAGTATATTTCCCTAAATCCCGAAAGAAAAACTGAATTAAGGTCTGATCAAAA
TGATAATAAGTCCAATAAGCCACATATTCCCGATGGATTGTGGGAAAAATGTGATAGCTGTAAGTCAATCATTTATGCTG
AAGACCTAAAAAAGAATTATCATATATGTCATGAATGTGGCCATCACTTTAGGATTGGTGCCCAGGAGCGAATTAACCAA
ATAATTGATGAAGATACCTGGGTGGAGTTAGATCAAAATATCATCTCTGAAAATCCTTTAGAATTTGAAGGCTACAGTGA
AAAAGTTGACAAGCTACAGAAAAAAACGGAATTGAAAGAAGCTATTCTAACCGGCTTAGGAAAAATTAATGGTCAGCAAG
CAGTGATCGGTGCTATGGATAGTAGGTTTTTAATGGGGAGTATGGGCTCTGTTGTCGGTGAAAAAGTTACTAGGGCTATA
GAGACTGGAATTGACGAAAACTTACCTGTTATTATGTTTACAGCATCAGGTGGGGCAAGAATGCAGGAAGGTATCTATTC
ATTGATGCAAATGGCAAAAACCAGTGCAGCAATTTCTAAACTTAAAGACAAGGGACTACCGTACATAGTAGTCCTTACGG
ACCCCACTACTGGTGGTGTTACTGCTAGTTTTGCTATGTTGGGTGATATAATTTTAGCAGAGCCCAATGCTTTAATAGGG
TTTGCCGGCAAAAGAGTTATAGAGCAAACTATTAAGCAAAAGCTACCTAAAGAATTTCAGAGAGCTGAATTTTTGTTAAA
ACACGGATTTGTAGACAAAGTGATAAATCGTAAAGAGATGAGAAATAAACTTAGTCACATTTTAAAGTTACACAAGACTA
AACAACCTTCTAGAATGTTAGATGGAAATGACTGTTCTTACTATTCCTCTAAAGATGCAAGTAAGAAGGCAAGTGCAAAA
AGTGTAGAGGAAATAAGGCAACAAGGTAAAAAGTTAACACCCTATGATAAAGTTAAGTTGGTGAGAAGTAAAGAGAGGCC
AACATCTTTAGACTATATAGATAATATATTTGAAGGCTTTATAGAATTTCACGGAGACAGATATTTCGCCGATGATACCA
GTATAGTTGGAGGATTGGCCTTCTTAAATGGTTTACCAGTAACCGTTATAGGACAGCAAAAGGGAAGAGATTTACAAGAA
AATATTTATAGGAATTTTGGCATGCCTAATCCTGAAGGTTATCGCAAGGCCGTAAGGCTTATGCAACAAGCTGAAAAGTT
TAACAGACCGATTATAAATTTTGTAGATACTTCAGGTGCTGGATGTGGTAAAGGAGCAGAAGAAAGGGGACAAGGTGAAG
CAATTGCACAAAACCTCTATACAATGTCTTCTTTAAAGGTTCCCATTATATCATTAGTCATCGGTGAAGGCGGTAGTGGA
GGTGCTTTAGCTTTAACGGTAGCTGATGAAGTATGGATGTTAGAGAATTCGGTTTACTCCATAGTTTCCCCTGAAGGTTT
TGCCAGCATATTATGGAAAGATTCTTCCAAGGCAAAAGAAGCAGCAGATGTAATGAAAATCACTGCTCAGGACTTGCAGG
AATTACAAATAATAGATAAAATCCTTGAAGAACCTTACCAAGATGCCAGTAAAGACGGCCAAGCCATGTCTGAAATTATT
AAAAATAACCTTTTGAAGACTCTTGATAACTTATCTAAAAAAGAAACAAATGACTTATTAACAAAAAGATATGAGAAGTT
CAGAAGTATAGGTAGATTTATTGAGAAATCCAATTTAGATAGTAGTATTAATCAATAG

Upstream 100 bases:

>100_bases
CTTAAATATCTTAAATAATGATGATTTTGTGAAAGGCATTTATGATACTAATTTCATAAATGACAAAATCTTTTAATCTA
AAGAACAAGGGGATGGTCAA

Downstream 100 bases:

>100_bases
TTAATGTTGTGAACAGCCATTATGATGACTAATACTAAAATTATAATTCCAATAAGATATCGCTTCATATTTACAAACAC
CCCTCTTAAAATTTCTAATC

Product: acetyl-CoA carboxylase, carboxyl transferase, beta subunit

Products: NA

Alternate protein names: ACCase subunits beta/alpha; Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MFKGLFKKTKYISLNPERKTELRSDQNDNKSNKPHIPDGLWEKCDSCKSIIYAEDLKKNYHICHECGHHFRIGAQERINQ
IIDEDTWVELDQNIISENPLEFEGYSEKVDKLQKKTELKEAILTGLGKINGQQAVIGAMDSRFLMGSMGSVVGEKVTRAI
ETGIDENLPVIMFTASGGARMQEGIYSLMQMAKTSAAISKLKDKGLPYIVVLTDPTTGGVTASFAMLGDIILAEPNALIG
FAGKRVIEQTIKQKLPKEFQRAEFLLKHGFVDKVINRKEMRNKLSHILKLHKTKQPSRMLDGNDCSYYSSKDASKKASAK
SVEEIRQQGKKLTPYDKVKLVRSKERPTSLDYIDNIFEGFIEFHGDRYFADDTSIVGGLAFLNGLPVTVIGQQKGRDLQE
NIYRNFGMPNPEGYRKAVRLMQQAEKFNRPIINFVDTSGAGCGKGAEERGQGEAIAQNLYTMSSLKVPIISLVIGEGGSG
GALALTVADEVWMLENSVYSIVSPEGFASILWKDSSKAKEAADVMKITAQDLQELQIIDKILEEPYQDASKDGQAMSEII
KNNLLKTLDNLSKKETNDLLTKRYEKFRSIGRFIEKSNLDSSINQ

Sequences:

>Translated_605_residues
MFKGLFKKTKYISLNPERKTELRSDQNDNKSNKPHIPDGLWEKCDSCKSIIYAEDLKKNYHICHECGHHFRIGAQERINQ
IIDEDTWVELDQNIISENPLEFEGYSEKVDKLQKKTELKEAILTGLGKINGQQAVIGAMDSRFLMGSMGSVVGEKVTRAI
ETGIDENLPVIMFTASGGARMQEGIYSLMQMAKTSAAISKLKDKGLPYIVVLTDPTTGGVTASFAMLGDIILAEPNALIG
FAGKRVIEQTIKQKLPKEFQRAEFLLKHGFVDKVINRKEMRNKLSHILKLHKTKQPSRMLDGNDCSYYSSKDASKKASAK
SVEEIRQQGKKLTPYDKVKLVRSKERPTSLDYIDNIFEGFIEFHGDRYFADDTSIVGGLAFLNGLPVTVIGQQKGRDLQE
NIYRNFGMPNPEGYRKAVRLMQQAEKFNRPIINFVDTSGAGCGKGAEERGQGEAIAQNLYTMSSLKVPIISLVIGEGGSG
GALALTVADEVWMLENSVYSIVSPEGFASILWKDSSKAKEAADVMKITAQDLQELQIIDKILEEPYQDASKDGQAMSEII
KNNLLKTLDNLSKKETNDLLTKRYEKFRSIGRFIEKSNLDSSINQ
>Mature_605_residues
MFKGLFKKTKYISLNPERKTELRSDQNDNKSNKPHIPDGLWEKCDSCKSIIYAEDLKKNYHICHECGHHFRIGAQERINQ
IIDEDTWVELDQNIISENPLEFEGYSEKVDKLQKKTELKEAILTGLGKINGQQAVIGAMDSRFLMGSMGSVVGEKVTRAI
ETGIDENLPVIMFTASGGARMQEGIYSLMQMAKTSAAISKLKDKGLPYIVVLTDPTTGGVTASFAMLGDIILAEPNALIG
FAGKRVIEQTIKQKLPKEFQRAEFLLKHGFVDKVINRKEMRNKLSHILKLHKTKQPSRMLDGNDCSYYSSKDASKKASAK
SVEEIRQQGKKLTPYDKVKLVRSKERPTSLDYIDNIFEGFIEFHGDRYFADDTSIVGGLAFLNGLPVTVIGQQKGRDLQE
NIYRNFGMPNPEGYRKAVRLMQQAEKFNRPIINFVDTSGAGCGKGAEERGQGEAIAQNLYTMSSLKVPIISLVIGEGGSG
GALALTVADEVWMLENSVYSIVSPEGFASILWKDSSKAKEAADVMKITAQDLQELQIIDKILEEPYQDASKDGQAMSEII
KNNLLKTLDNLSKKETNDLLTKRYEKFRSIGRFIEKSNLDSSINQ

Specific function: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

COG id: COG0825

COG function: function code I; Acetyl-CoA carboxylase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the AccA family

Homologues:

Organism=Escherichia coli, GI1788655, Length=279, Percent_Identity=48.7455197132617, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1786382, Length=272, Percent_Identity=53.6764705882353, Blast_Score=287, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI25147359, Length=459, Percent_Identity=21.1328976034858, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=459, Percent_Identity=21.1328976034858, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCDA_NATTJ (B2A865)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917019.1
- ProteinModelPortal:   B2A865
- GeneID:   6315657
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0846
- HOGENOM:   HBG668219
- OMA:   GASAIVH
- ProtClustDB:   CLSK911920
- HAMAP:   MF_00823
- HAMAP:   MF_01395
- InterPro:   IPR001095
- InterPro:   IPR000438
- InterPro:   IPR011763
- InterPro:   IPR011762
- PANTHER:   PTHR22855:SF3
- PRINTS:   PR01069
- TIGRFAMs:   TIGR00513
- TIGRFAMs:   TIGR00515

Pfam domain/function: PF03255 ACCA

EC number: =6.4.1.2

Molecular weight: Translated: 67609; Mature: 67609

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKGLFKKTKYISLNPERKTELRSDQNDNKSNKPHIPDGLWEKCDSCKSIIYAEDLKKNY
CCCCHHCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HICHECGHHFRIGAQERINQIIDEDTWVELDQNIISENPLEFEGYSEKVDKLQKKTELKE
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AILTGLGKINGQQAVIGAMDSRFLMGSMGSVVGEKVTRAIETGIDENLPVIMFTASGGAR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
MQEGIYSLMQMAKTSAAISKLKDKGLPYIVVLTDPTTGGVTASFAMLGDIILAEPNALIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHEECCCHHEE
FAGKRVIEQTIKQKLPKEFQRAEFLLKHGFVDKVINRKEMRNKLSHILKLHKTKQPSRML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DGNDCSYYSSKDASKKASAKSVEEIRQQGKKLTPYDKVKLVRSKERPTSLDYIDNIFEGF
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
IEFHGDRYFADDTSIVGGLAFLNGLPVTVIGQQKGRDLQENIYRNFGMPNPEGYRKAVRL
HHHCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
MQQAEKFNRPIINFVDTSGAGCGKGAEERGQGEAIAQNLYTMSSLKVPIISLVIGEGGSG
HHHHHHHCCCCEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GALALTVADEVWMLENSVYSIVSPEGFASILWKDSSKAKEAADVMKITAQDLQELQIIDK
CEEEEEEHHHHHHHHCCHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILEEPYQDASKDGQAMSEIIKNNLLKTLDNLSKKETNDLLTKRYEKFRSIGRFIEKSNLD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSINQ
CCCCC
>Mature Secondary Structure
MFKGLFKKTKYISLNPERKTELRSDQNDNKSNKPHIPDGLWEKCDSCKSIIYAEDLKKNY
CCCCHHCCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HICHECGHHFRIGAQERINQIIDEDTWVELDQNIISENPLEFEGYSEKVDKLQKKTELKE
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AILTGLGKINGQQAVIGAMDSRFLMGSMGSVVGEKVTRAIETGIDENLPVIMFTASGGAR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
MQEGIYSLMQMAKTSAAISKLKDKGLPYIVVLTDPTTGGVTASFAMLGDIILAEPNALIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHEECCCHHEE
FAGKRVIEQTIKQKLPKEFQRAEFLLKHGFVDKVINRKEMRNKLSHILKLHKTKQPSRML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DGNDCSYYSSKDASKKASAKSVEEIRQQGKKLTPYDKVKLVRSKERPTSLDYIDNIFEGF
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
IEFHGDRYFADDTSIVGGLAFLNGLPVTVIGQQKGRDLQENIYRNFGMPNPEGYRKAVRL
HHHCCCEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
MQQAEKFNRPIINFVDTSGAGCGKGAEERGQGEAIAQNLYTMSSLKVPIISLVIGEGGSG
HHHHHHHCCCCEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GALALTVADEVWMLENSVYSIVSPEGFASILWKDSSKAKEAADVMKITAQDLQELQIIDK
CEEEEEEHHHHHHHHCCHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILEEPYQDASKDGQAMSEIIKNNLLKTLDNLSKKETNDLLTKRYEKFRSIGRFIEKSNLD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSINQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA