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The map label for this gene is accC [H]

Identifier: 188585473

GI number: 188585473

Start: 890132

End: 891469

Strand: Direct

Name: accC [H]

Synonym: Nther_0845

Alternate gene names: 188585473

Gene position: 890132-891469 (Clockwise)

Preceding gene: 188585472

Following gene: 188585474

Centisome position: 28.12

GC content: 38.49

Gene sequence:

>1338_bases
ATGTTTAATAAAATTTTGGTGGCTAATAGAGGTGAAATTGCTGTTAGAATAATCAGAGCTTGTAGAGAAATGGGGATTGA
AACAGTAGCTGTTTATTCTACTGTAGATGAAGAAGCTCTACACGTCCAAATGGCAGATGAATCCGTTTGTATCGGCACGG
CAACCGATAACTGCTATACGAATATTAGCAGGATATTGACTGCTGCGGAAATCACTGATGCTGAAGCCATCCATCCTGGA
TTTGGGTTTTTATCAGAAAACAGTCGTTTTGCCGATGTCTGTAGAAAATGTAATATTACATTTATTGGTCCCAGGCCAGA
GGTGATTGAGAACATGGGAAACAAGTCCAATGCCAGGAAGTTAATGGCAAATGCTGATGTTCCAGTGGTCCCAGGTTCTA
AGAAACCTTTAACAGATGAGCAAGATGCTGTACAGATGGCTGACGAACTTGGATATCCGGTGATGATTAAAGCATCAGCC
GGTGGTGGTGGCAGAGGTATACGAATTATCAGAAGCCAAGCCGAACTGTTAAATGCTCTTGGTACAGCCAAACAAGAAGC
CGCTACTTTTTTCGGTGATGACACAATGTATATGGAAAAGTATTTAGAAAAGCCAAGACACGTGGAAATACAAATACTTG
CTGATAAATACGGGAATGTACTGCACCTAGGGGAAAGAGATTGCTCTATCCAGAGAAGGAATCAAAAAGTTTTAGAAGAA
GCCCCATGTCCAGTGATGACTGAGGAACTCAGAGAAAAAATGGGACAAGCTGCAGTCAGGGCAGCTAAATATGTGGGATA
TCAAAATGCGGGAACAATTGAATTTTTATTAGACAAACACAACAATTTCTATTTTATGGAAATGAATACCAGGATTCAAG
TTGAACACCCGGTTACAGAACAAATAGTGGGACTGGATTTGATAAAGGAGCAAATAAAAATTGCTGCAGGACAAAGGCTC
GAAAAAACTCAAGAGGAGATAAATTTAAACGGACATTCCATCGAATGTAGAATCAATGCCGAGGATCCGCAAAAAAATTT
CATGCCATGTCCGGGTAAGGTAAACGGGCTATTTATACCTAGTGGTTTAGGAGTAAGAGTTGATTCTTTGTTGTATGATG
GCTATGAGATACCATCAACCTACGATTCAATGATAGCAAAACTGATAGTCCATGGCAAAGATAGGGAAGAAGCAATTAAT
AAAATGAAGAGAGCCTTAGGAGAATTTGTGATACTTGGTGTTAAAAATAATGTTGAATTCCACTTAAATATCTTAAATAA
TGATGATTTTGTGAAAGGCATTTATGATACTAATTTCATAAATGACAAAATCTTTTAA

Upstream 100 bases:

>100_bases
GAACGGTGATACGGTAGAATACGGCCAGGAACTCTTTAAAATTAAAACAAGTCAATAACAACCTGATAACAAGCCAATAA
TGTAATAAAGGATGATGAAT

Downstream 100 bases:

>100_bases
TCTAAAGAACAAGGGGATGGTCAAGTGTTTAAAGGACTATTTAAAAAAACAAAGTATATTTCCCTAAATCCCGAAAGAAA
AACTGAATTAAGGTCTGATC

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFNKILVANRGEIAVRIIRACREMGIETVAVYSTVDEEALHVQMADESVCIGTATDNCYTNISRILTAAEITDAEAIHPG
FGFLSENSRFADVCRKCNITFIGPRPEVIENMGNKSNARKLMANADVPVVPGSKKPLTDEQDAVQMADELGYPVMIKASA
GGGGRGIRIIRSQAELLNALGTAKQEAATFFGDDTMYMEKYLEKPRHVEIQILADKYGNVLHLGERDCSIQRRNQKVLEE
APCPVMTEELREKMGQAAVRAAKYVGYQNAGTIEFLLDKHNNFYFMEMNTRIQVEHPVTEQIVGLDLIKEQIKIAAGQRL
EKTQEEINLNGHSIECRINAEDPQKNFMPCPGKVNGLFIPSGLGVRVDSLLYDGYEIPSTYDSMIAKLIVHGKDREEAIN
KMKRALGEFVILGVKNNVEFHLNILNNDDFVKGIYDTNFINDKIF

Sequences:

>Translated_445_residues
MFNKILVANRGEIAVRIIRACREMGIETVAVYSTVDEEALHVQMADESVCIGTATDNCYTNISRILTAAEITDAEAIHPG
FGFLSENSRFADVCRKCNITFIGPRPEVIENMGNKSNARKLMANADVPVVPGSKKPLTDEQDAVQMADELGYPVMIKASA
GGGGRGIRIIRSQAELLNALGTAKQEAATFFGDDTMYMEKYLEKPRHVEIQILADKYGNVLHLGERDCSIQRRNQKVLEE
APCPVMTEELREKMGQAAVRAAKYVGYQNAGTIEFLLDKHNNFYFMEMNTRIQVEHPVTEQIVGLDLIKEQIKIAAGQRL
EKTQEEINLNGHSIECRINAEDPQKNFMPCPGKVNGLFIPSGLGVRVDSLLYDGYEIPSTYDSMIAKLIVHGKDREEAIN
KMKRALGEFVILGVKNNVEFHLNILNNDDFVKGIYDTNFINDKIF
>Mature_445_residues
MFNKILVANRGEIAVRIIRACREMGIETVAVYSTVDEEALHVQMADESVCIGTATDNCYTNISRILTAAEITDAEAIHPG
FGFLSENSRFADVCRKCNITFIGPRPEVIENMGNKSNARKLMANADVPVVPGSKKPLTDEQDAVQMADELGYPVMIKASA
GGGGRGIRIIRSQAELLNALGTAKQEAATFFGDDTMYMEKYLEKPRHVEIQILADKYGNVLHLGERDCSIQRRNQKVLEE
APCPVMTEELREKMGQAAVRAAKYVGYQNAGTIEFLLDKHNNFYFMEMNTRIQVEHPVTEQIVGLDLIKEQIKIAAGQRL
EKTQEEINLNGHSIECRINAEDPQKNFMPCPGKVNGLFIPSGLGVRVDSLLYDGYEIPSTYDSMIAKLIVHGKDREEAIN
KMKRALGEFVILGVKNNVEFHLNILNNDDFVKGIYDTNFINDKIF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=48.2993197278912, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=50.6756756756757, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=50.6756756756757, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=50.6756756756757, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.8609865470852, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.8609865470852, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.8609865470852, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI38679960, Length=502, Percent_Identity=32.2709163346614, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=32.2709163346614, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=32.2709163346614, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=32.2709163346614, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=32.2709163346614, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=31.3609467455621, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=53.8116591928251, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=49.0950226244344, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=46.9387755102041, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=45.1901565995526, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=30.9572301425662, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=440, Percent_Identity=30.2272727272727, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=440, Percent_Identity=30.2272727272727, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=44.2437923250564, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=47.7777777777778, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=47.7678571428571, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=31.9688109161793, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=489, Percent_Identity=32.3108384458078, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.2921348314607, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.2972972972973, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.2972972972973, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.2972972972973, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.2972972972973, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.2972972972973, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.2972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.2972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.2972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.2972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.2972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.343137254902, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=31.7269076305221, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=31.7269076305221, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=31.7269076305221, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=31.7269076305221, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49672; Mature: 49672

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILVANRGEIAVRIIRACREMGIETVAVYSTVDEEALHVQMADESVCIGTATDNCYT
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCHHHH
NISRILTAAEITDAEAIHPGFGFLSENSRFADVCRKCNITFIGPRPEVIENMGNKSNARK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCHHHH
LMANADVPVVPGSKKPLTDEQDAVQMADELGYPVMIKASAGGGGRGIRIIRSQAELLNAL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHHHHHHH
GTAKQEAATFFGDDTMYMEKYLEKPRHVEIQILADKYGNVLHLGERDCSIQRRNQKVLEE
CCCHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
APCPVMTEELREKMGQAAVRAAKYVGYQNAGTIEFLLDKHNNFYFMEMNTRIQVEHPVTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHHH
QIVGLDLIKEQIKIAAGQRLEKTQEEINLNGHSIECRINAEDPQKNFMPCPGKVNGLFIP
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEC
SGLGVRVDSLLYDGYEIPSTYDSMIAKLIVHGKDREEAINKMKRALGEFVILGVKNNVEF
CCCCCEEHHHEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCEEE
HLNILNNDDFVKGIYDTNFINDKIF
EEEEECCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MFNKILVANRGEIAVRIIRACREMGIETVAVYSTVDEEALHVQMADESVCIGTATDNCYT
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCHHHH
NISRILTAAEITDAEAIHPGFGFLSENSRFADVCRKCNITFIGPRPEVIENMGNKSNARK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCHHHH
LMANADVPVVPGSKKPLTDEQDAVQMADELGYPVMIKASAGGGGRGIRIIRSQAELLNAL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHHHHHHH
GTAKQEAATFFGDDTMYMEKYLEKPRHVEIQILADKYGNVLHLGERDCSIQRRNQKVLEE
CCCHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
APCPVMTEELREKMGQAAVRAAKYVGYQNAGTIEFLLDKHNNFYFMEMNTRIQVEHPVTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHHH
QIVGLDLIKEQIKIAAGQRLEKTQEEINLNGHSIECRINAEDPQKNFMPCPGKVNGLFIP
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEC
SGLGVRVDSLLYDGYEIPSTYDSMIAKLIVHGKDREEAINKMKRALGEFVILGVKNNVEF
CCCCCEEHHHEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCEEE
HLNILNNDDFVKGIYDTNFINDKIF
EEEEECCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]