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The map label for this gene is lexA [H]

Identifier: 188585438

GI number: 188585438

Start: 843362

End: 845809

Strand: Direct

Name: lexA [H]

Synonym: Nther_0809

Alternate gene names: 188585438

Gene position: 843362-845809 (Clockwise)

Preceding gene: 188585437

Following gene: 188585439

Centisome position: 26.64

GC content: 33.37

Gene sequence:

>2448_bases
ATGGAACTAAATGTTGATCAGAAGCGGATTATTGAAACCAAACCTGGTGGACACATGTTGATAAGAGGAGTGGCAGGAAG
CGGGAAAACAACTGTAGCTGTACATAAAATTCCTCATTTACTCAATCACTATTGCTCTCAGGATGACAAGGTCCTGGTTA
TTACCTTTACTAAAACTTTAATAAACTACATTAATTATATATACAACAATATAGAACATGAAACCACCTTATTTTCTATG
ATAAATAGTGATCAAAATTTACAGATCTCAACTGCAGATAAAATCATCTTTCACCTTTATCGAAAGTATGAAGAAAAAGC
AGGGATAGAAGAGCGAGAGATCATACCTCAAAAAGAAAAATATAGATTATTAAACCAAGCTATTAAATATATTTCAAAGA
AATATCCAGATCAGACTGTTGTTTCTGATAGGAATGTTAATTTCTTAATTGATGAAATCGAGTGGATCAAAAGCAATAGA
TACACTGAGCTAGAAGTATATCAAAATGTAGATAGATTAGGTAGAAGCAGGAATATGGAAGAAGACGGTCCTCAAAGAAT
ACTAAAAAACTCCACTAACAGAGAAGCCATATTTAAGACTATGGTGCTTTACGATGAATTGATGGACAAGGAAGGTTATA
CTGATTTTAAAAACATGGCCCTTCAGGTGTTGAAGGGAATAGAAGAAGGTGTAATCACTTGCGATAAATTCACTCATATA
TTGGTAGATGAAAGTCAAGATCTCAGCAGAGTCCAGTTAGAAATTATTAAAAATATGTTTAAAAATGATAAGAATTACTC
AAGTGTTATTTTCATAGCCGATACAGCTCAGAGTATTTACCTCCAGTCCTGGCTGTCTCATCAAAGTTTTAAAAGTATTG
GCTTTGATATGTCAGGTAGGGCCAGAACTTTATCTAAGAATTATAGGACAACAGCTGAAATAGCTGAAGCAGCCTATAGT
TTAATTGAAGATGATCAAACCATTGTTAATAACGAAAATTATGTAGAACCAGCAATTATTGATCGAAGGGGAGAACACCC
TGTTTATAAGCAATTTGACTCTGATGGAGAAGAGTTAGATTATGTCTGTGATATGATTAAAAATAATTTATATAAACACT
ATGATCTCAAGGATATAGCCATAATAGCTAAAACCAGGAGACAATTAGAAAATGCTAAAAGATATCTACTAAATAATAAA
GTTGATTGCAAGATTTTGAGTAAACGGGAAAATCATTTTTCCGATGATAAGGTTAAATTGTTGACCATGCATTCTATCAA
AGGCCTGGAATATAAAGTTGTGTTCATTATTGGTATTAATGAAAATGTGATTCCATATAGCCCTGATGGTAATATTGACC
TGGAACAAGAGTCCATGGAACGAAGGTTATTATATGTAGGAATGACCCGGGCCAAAGACAAGCTATTTTTAACCTCTAGT
GGAAACCCCTCCAAATTCATTAATGATATCAATCCCAAGTACCTTAAACTAAATAATGAAAATGGGTTTTCCAGGTTTAA
TCATATTGGTATAGATAGTTACAGGTTTAAGGAAAAAATAGTGGATCTATACAGCCATGAAGAAGTGGTTAGACAATGGG
TGATAGAAGAGCTAATCAATACTTTAAATTATCCCTTAGAACTAATAGACATAGAATATGAAATTCAATTGTTTTCAGCC
ACGGGATATGTAGATATCGTTGTCTTTAAAAATATGAAAGGAAAAATTGTCCCCTATATATTCATAGAGGCTAAACATTA
TAATACCAGCTTAGATAAACAAGATGTCAACCAGCTGAAATCGTACCTAGAAGGAAATAGTAGTGTAGAATATGGTATGC
TGACAAATGGTAAAGATTTCAAGATACTAAAAAAGCAAAGTAAAAAGGGTGAATTTGAATATATTGATTCATTACCGGAT
TATCAAGGGGATATCAATAGTCTCTTTGAAGAATTTGAATATATAGACCTGAAGCGAGATAAAAAATACAAGCTCCATCG
AAATCTAGAAGATAAATCATTGATTCATGTATATGATGAAAAAATAGATAATTCTCTAGAAGTTTCGGAGTATGTAAAAC
TAAATGTCTATGGAGAACTGACAGCTGGAGAGTTGAAATATGCTCATCAAGATATCCAGGGGGATGTGGAACTACCTAAA
GAGATTGTACCTAATCCAGATAACTGTTTCATGTTAGAAGTGACGGGGGATAGTATGATTAATGCTGGTATCGATAAAGG
TGACTATGTAATAGTCCAAAAACAAAATTATGCCGAAAACCTGGATATAGTAGTTGCGGTGATAGATCAAGAAGCGACCT
TGAAGAAGTATAGCCGGATGGGAGATACGATCCTGCTAATGCCTGAGAATAAGAACTATGAACCAATTATTGTTAGTGAG
GAAGATTTAATAATTAATGGAAAGGTGATTGGGGTGTTGAAGACATAA

Upstream 100 bases:

>100_bases
TTAGTCTAGAATTACGAAATTTGTAGGATTTCCTGAAGAATTGTAGAAGAAATAAAACAAGGCATTACCAAAAAATTGAA
ACTATGAATTGGGTGATTAC

Downstream 100 bases:

>100_bases
ATATATGTGAATCATTATAATTCAGATAGAACAAATTAGTTTGGAGAAGGGAGAGAGTTTAATTGGATAACTCTAATATT
AAAGCCGGTGAAATTTATGT

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MELNVDQKRIIETKPGGHMLIRGVAGSGKTTVAVHKIPHLLNHYCSQDDKVLVITFTKTLINYINYIYNNIEHETTLFSM
INSDQNLQISTADKIIFHLYRKYEEKAGIEEREIIPQKEKYRLLNQAIKYISKKYPDQTVVSDRNVNFLIDEIEWIKSNR
YTELEVYQNVDRLGRSRNMEEDGPQRILKNSTNREAIFKTMVLYDELMDKEGYTDFKNMALQVLKGIEEGVITCDKFTHI
LVDESQDLSRVQLEIIKNMFKNDKNYSSVIFIADTAQSIYLQSWLSHQSFKSIGFDMSGRARTLSKNYRTTAEIAEAAYS
LIEDDQTIVNNENYVEPAIIDRRGEHPVYKQFDSDGEELDYVCDMIKNNLYKHYDLKDIAIIAKTRRQLENAKRYLLNNK
VDCKILSKRENHFSDDKVKLLTMHSIKGLEYKVVFIIGINENVIPYSPDGNIDLEQESMERRLLYVGMTRAKDKLFLTSS
GNPSKFINDINPKYLKLNNENGFSRFNHIGIDSYRFKEKIVDLYSHEEVVRQWVIEELINTLNYPLELIDIEYEIQLFSA
TGYVDIVVFKNMKGKIVPYIFIEAKHYNTSLDKQDVNQLKSYLEGNSSVEYGMLTNGKDFKILKKQSKKGEFEYIDSLPD
YQGDINSLFEEFEYIDLKRDKKYKLHRNLEDKSLIHVYDEKIDNSLEVSEYVKLNVYGELTAGELKYAHQDIQGDVELPK
EIVPNPDNCFMLEVTGDSMINAGIDKGDYVIVQKQNYAENLDIVVAVIDQEATLKKYSRMGDTILLMPENKNYEPIIVSE
EDLIINGKVIGVLKT

Sequences:

>Translated_815_residues
MELNVDQKRIIETKPGGHMLIRGVAGSGKTTVAVHKIPHLLNHYCSQDDKVLVITFTKTLINYINYIYNNIEHETTLFSM
INSDQNLQISTADKIIFHLYRKYEEKAGIEEREIIPQKEKYRLLNQAIKYISKKYPDQTVVSDRNVNFLIDEIEWIKSNR
YTELEVYQNVDRLGRSRNMEEDGPQRILKNSTNREAIFKTMVLYDELMDKEGYTDFKNMALQVLKGIEEGVITCDKFTHI
LVDESQDLSRVQLEIIKNMFKNDKNYSSVIFIADTAQSIYLQSWLSHQSFKSIGFDMSGRARTLSKNYRTTAEIAEAAYS
LIEDDQTIVNNENYVEPAIIDRRGEHPVYKQFDSDGEELDYVCDMIKNNLYKHYDLKDIAIIAKTRRQLENAKRYLLNNK
VDCKILSKRENHFSDDKVKLLTMHSIKGLEYKVVFIIGINENVIPYSPDGNIDLEQESMERRLLYVGMTRAKDKLFLTSS
GNPSKFINDINPKYLKLNNENGFSRFNHIGIDSYRFKEKIVDLYSHEEVVRQWVIEELINTLNYPLELIDIEYEIQLFSA
TGYVDIVVFKNMKGKIVPYIFIEAKHYNTSLDKQDVNQLKSYLEGNSSVEYGMLTNGKDFKILKKQSKKGEFEYIDSLPD
YQGDINSLFEEFEYIDLKRDKKYKLHRNLEDKSLIHVYDEKIDNSLEVSEYVKLNVYGELTAGELKYAHQDIQGDVELPK
EIVPNPDNCFMLEVTGDSMINAGIDKGDYVIVQKQNYAENLDIVVAVIDQEATLKKYSRMGDTILLMPENKNYEPIIVSE
EDLIINGKVIGVLKT
>Mature_815_residues
MELNVDQKRIIETKPGGHMLIRGVAGSGKTTVAVHKIPHLLNHYCSQDDKVLVITFTKTLINYINYIYNNIEHETTLFSM
INSDQNLQISTADKIIFHLYRKYEEKAGIEEREIIPQKEKYRLLNQAIKYISKKYPDQTVVSDRNVNFLIDEIEWIKSNR
YTELEVYQNVDRLGRSRNMEEDGPQRILKNSTNREAIFKTMVLYDELMDKEGYTDFKNMALQVLKGIEEGVITCDKFTHI
LVDESQDLSRVQLEIIKNMFKNDKNYSSVIFIADTAQSIYLQSWLSHQSFKSIGFDMSGRARTLSKNYRTTAEIAEAAYS
LIEDDQTIVNNENYVEPAIIDRRGEHPVYKQFDSDGEELDYVCDMIKNNLYKHYDLKDIAIIAKTRRQLENAKRYLLNNK
VDCKILSKRENHFSDDKVKLLTMHSIKGLEYKVVFIIGINENVIPYSPDGNIDLEQESMERRLLYVGMTRAKDKLFLTSS
GNPSKFINDINPKYLKLNNENGFSRFNHIGIDSYRFKEKIVDLYSHEEVVRQWVIEELINTLNYPLELIDIEYEIQLFSA
TGYVDIVVFKNMKGKIVPYIFIEAKHYNTSLDKQDVNQLKSYLEGNSSVEYGMLTNGKDFKILKKQSKKGEFEYIDSLPD
YQGDINSLFEEFEYIDLKRDKKYKLHRNLEDKSLIHVYDEKIDNSLEVSEYVKLNVYGELTAGELKYAHQDIQGDVELPK
EIVPNPDNCFMLEVTGDSMINAGIDKGDYVIVQKQNYAENLDIVVAVIDQEATLKKYSRMGDTILLMPENKNYEPIIVSE
EDLIINGKVIGVLKT

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=124, Percent_Identity=37.0967741935484, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787431, Length=104, Percent_Identity=37.5, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 94725; Mature: 94725

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNVDQKRIIETKPGGHMLIRGVAGSGKTTVAVHKIPHLLNHYCSQDDKVLVITFTKTL
CCCCCCHHHHEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEHHHH
INYINYIYNNIEHETTLFSMINSDQNLQISTADKIIFHLYRKYEEKAGIEEREIIPQKEK
HHHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHCCCCHHH
YRLLNQAIKYISKKYPDQTVVSDRNVNFLIDEIEWIKSNRYTELEVYQNVDRLGRSRNME
HHHHHHHHHHHHHHCCCCCEECCCCCEEEEHHHHHHHCCCCEEHHHHHHHHHHHHCCCCC
EDGPQRILKNSTNREAIFKTMVLYDELMDKEGYTDFKNMALQVLKGIEEGVITCDKFTHI
CCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEHHHHEEE
LVDESQDLSRVQLEIIKNMFKNDKNYSSVIFIADTAQSIYLQSWLSHQSFKSIGFDMSGR
EECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
ARTLSKNYRTTAEIAEAAYSLIEDDQTIVNNENYVEPAIIDRRGEHPVYKQFDSDGEELD
HHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCCCCCCCCHHHHCCCCCHHHH
YVCDMIKNNLYKHYDLKDIAIIAKTRRQLENAKRYLLNNKVDCKILSKRENHFSDDKVKL
HHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEE
LTMHSIKGLEYKVVFIIGINENVIPYSPDGNIDLEQESMERRLLYVGMTRAKDKLFLTSS
EEEECCCCCEEEEEEEEECCCCCCCCCCCCCEEECHHHHHCEEEEEEEECCCCEEEEECC
GNPSKFINDINPKYLKLNNENGFSRFNHIGIDSYRFKEKIVDLYSHEEVVRQWVIEELIN
CCHHHHHHCCCCCEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLNYPLELIDIEYEIQLFSATGYVDIVVFKNMKGKIVPYIFIEAKHYNTSLDKQDVNQLK
HHCCCEEEEEEEEEEEEEEECCEEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHH
SYLEGNSSVEYGMLTNGKDFKILKKQSKKGEFEYIDSLPDYQGDINSLFEEFEYIDLKRD
HHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHEECCCC
KKYKLHRNLEDKSLIHVYDEKIDNSLEVSEYVKLNVYGELTAGELKYAHQDIQGDVELPK
CCHHHHCCCCCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCH
EIVPNPDNCFMLEVTGDSMINAGIDKGDYVIVQKQNYAENLDIVVAVIDQEATLKKYSRM
HHCCCCCCEEEEEECCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHC
GDTILLMPENKNYEPIIVSEEDLIINGKVIGVLKT
CCEEEEEECCCCCCEEEECCCCEEECCEEEEEEEC
>Mature Secondary Structure
MELNVDQKRIIETKPGGHMLIRGVAGSGKTTVAVHKIPHLLNHYCSQDDKVLVITFTKTL
CCCCCCHHHHEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEHHHH
INYINYIYNNIEHETTLFSMINSDQNLQISTADKIIFHLYRKYEEKAGIEEREIIPQKEK
HHHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHCCCCHHH
YRLLNQAIKYISKKYPDQTVVSDRNVNFLIDEIEWIKSNRYTELEVYQNVDRLGRSRNME
HHHHHHHHHHHHHHCCCCCEECCCCCEEEEHHHHHHHCCCCEEHHHHHHHHHHHHCCCCC
EDGPQRILKNSTNREAIFKTMVLYDELMDKEGYTDFKNMALQVLKGIEEGVITCDKFTHI
CCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEHHHHEEE
LVDESQDLSRVQLEIIKNMFKNDKNYSSVIFIADTAQSIYLQSWLSHQSFKSIGFDMSGR
EECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
ARTLSKNYRTTAEIAEAAYSLIEDDQTIVNNENYVEPAIIDRRGEHPVYKQFDSDGEELD
HHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCCCCCCCCHHHHCCCCCHHHH
YVCDMIKNNLYKHYDLKDIAIIAKTRRQLENAKRYLLNNKVDCKILSKRENHFSDDKVKL
HHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEE
LTMHSIKGLEYKVVFIIGINENVIPYSPDGNIDLEQESMERRLLYVGMTRAKDKLFLTSS
EEEECCCCCEEEEEEEEECCCCCCCCCCCCCEEECHHHHHCEEEEEEEECCCCEEEEECC
GNPSKFINDINPKYLKLNNENGFSRFNHIGIDSYRFKEKIVDLYSHEEVVRQWVIEELIN
CCHHHHHHCCCCCEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLNYPLELIDIEYEIQLFSATGYVDIVVFKNMKGKIVPYIFIEAKHYNTSLDKQDVNQLK
HHCCCEEEEEEEEEEEEEEECCEEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHH
SYLEGNSSVEYGMLTNGKDFKILKKQSKKGEFEYIDSLPDYQGDINSLFEEFEYIDLKRD
HHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHEECCCC
KKYKLHRNLEDKSLIHVYDEKIDNSLEVSEYVKLNVYGELTAGELKYAHQDIQGDVELPK
CCHHHHCCCCCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCH
EIVPNPDNCFMLEVTGDSMINAGIDKGDYVIVQKQNYAENLDIVVAVIDQEATLKKYSRM
HHCCCCCCEEEEEECCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHC
GDTILLMPENKNYEPIIVSEEDLIINGKVIGVLKT
CCEEEEEECCCCCCEEEECCCCEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA