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The map label for this gene is xdhA [H]

Identifier: 188585395

GI number: 188585395

Start: 791883

End: 794135

Strand: Direct

Name: xdhA [H]

Synonym: Nther_0765

Alternate gene names: 188585395

Gene position: 791883-794135 (Clockwise)

Preceding gene: 188585392

Following gene: 188585396

Centisome position: 25.02

GC content: 36.35

Gene sequence:

>2253_bases
ATGCAAATAATAGGTTCTTCTTACCCAACTCATGATGCAAAGGGTAAAGCTACTGGACAGACTGCCTATGCTGGTGATAT
GCAACTAGCAGGAATGTTACATGCTGCTGTGTTGTTTAGTCCAATTCCTCATGGATACGTTAAGTCAATTGATGACTCAA
AAGCATTGGCATTACCAGGGGTTGTTAAAGTATTACATTGTTTTAATACAACCCAAAAGGAGTTCTCTAGATATCGAACT
TTTGTTGGACAACCTGTTCCAGATCAAGAAAGAGTTTTTAATAATCATGTTCGTTTTGTAGGGGACAGAGTAGCTGCAGT
TATTGCTGAAACAGAAGAAATTGCTCGTAAAGCTGTGGAACTTATTGAAGTAACTTATGAAGAATTACCATATTCATTAT
CACCAGAGCAAACGTTAAATGGTTCAATAGATAATATCCATAAAGACGGTGCTGTCTATGGTGATCTTCATAAAGAAGTT
GGGGACGAAAGTAAAGTGGATCCTTCAGCAATTGAAATTACTACTAGCAATAAGTTAGATAGGCTCAACCATCTCACTAT
GGAAACTCACAGTTGTGTAGCAAATTATGATCATGGGTTAGATGAGTTGACTATATGGAGTCCAAACCAAAGTGTCCATG
GCTTAAGAACTGTAGTTGGTGATTTGTTTGAAATACCTTATCATAAGATAAGAGTAATTAAAACTACCATGGGTGGTTCC
TTTGGTGCAAAACAAGAATGGGTATTAGAACCTGTGGCTGCGTGTTGTGCACTCAGTGTTGGAAAACCAGTTAAATTGGT
ATATAACCGGGCTGAGAGTATGGTATCAGTATACGGTAGAGGAGCCGTTGAATCTAAGATTACATCAAAAATAACAAAAG
ACGGTAAGCTACAGAGCTTTACAACGGATATAACTTTAGATGCTGGAGCTTACTTAGGAAATTCATATGTTTATATTAAT
ACAATGCTCGGTAAATTCTTCCGTTGCTATAAATATCCTTATGTAGATTTTACTGCTAGAACTACATGTACTAATACACC
TGTATCTGGAGGGTTTAGAGGATGGTCAGGACCAGAGGCTACATTAATGATTGAACATAACTTAAATGTAGCTGCTAAAA
GACTTAATATTGATCCTGTTGAATTGAGATTAAAAAATGTTGCTTTACCAGGAGACAAGGATATTTACATAGATCGTGAT
CTTGGAGAAATTCGCCTTAAAGAATCCTTAGAATTAGGTAGAGAAAAGTTTAACTGGGAATTAAGAAAGAAAGAAGTATC
TGAATTTAATAGCAAAAACAATCGTTATAAACGTGGTATAGGTGTAGCTTGCGGTGGACATGTGAACGGATTTACACCAA
AAAGAGGAGAATTTGCAACAGTGGATATGAGAATGACGGAAGATGGAAGTATTCAAGCAAACGTAACTTTACATGACCAT
GGATGTGGTACCGTAACAACTTTCCAAATGATTGTTGCTGAAGAATTAGGCATTCCTCTTGATATGGTTTCAGTGAAAGA
AGGAGATACTTTCGTATCACCATATGATTATGGATGTTATTCAAGTAGAACAGTTTATGTATTAGGACGAGCAGCACAAG
AGTGTGCTAAAGAAATAAAAAGAGTTTTAGGGAAAAATATAGCTGAGTTACACAATATTCCACTAGAAGATATAGAGGTT
GTCAATGGGTATGTTCGCTCCAAAAAAGATGAGGAAATTAACTATACTTATGCTGAGGCATCTGTTAAGAGTTTATTTGA
GCTAGGAAAAGAAGTTGTTGCAACTTATCAACATAAAGATGATACCAATCCTAGTGTGACGGCTGCTCACTTCGCACTTG
TGGAAGTAGACACATATACAGGCATGACAAAAACTTTAGATTATTTAGCAGTACATGACATAGGAAAAGCTCTTAATCGT
GAAATGTGTATAGCCCAAATTGAAGGTTCGGTTACTATGGGAATGGGTGCTGCCATATCTGAACACTTAACTGTTTCTGA
ACAGGGGCAAAGTACTAATAGTATGAAAGATTATCATGTAGTTAATTGTTATGATGCACCAAATGTAAGAGTAGAACTTA
TTGAAGATGGTGGAACAGACGGTCCATATGGAGCAAAATCAATAGGTGAAATAGCACATATACCAGTAACAGCAACAATC
GTTGGTGCAATAAATGATGCATTATCAACTGAAATTTGTGAAATTCCAATTAATCCAGATAAAATTGCTAAACTTATGAG
TGGGAGGGCTTAA

Upstream 100 bases:

>100_bases
AGTGACTTAACCATGATGTGTCCAAGAATTTATACTAACACCACACTTTCATATGTATATAATTTGTACTTAATAATTCA
AATAAAAGGGGTGCTAATTA

Downstream 100 bases:

>100_bases
CATGAAGCTAAATTTTAAAGTAAATGGCAAAGATAGAACCTTAGAGGTGGATGGAAATAGACGTCTGATAGATATATTAA
GAGAAGACTTAGGATTAACA

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MQIIGSSYPTHDAKGKATGQTAYAGDMQLAGMLHAAVLFSPIPHGYVKSIDDSKALALPGVVKVLHCFNTTQKEFSRYRT
FVGQPVPDQERVFNNHVRFVGDRVAAVIAETEEIARKAVELIEVTYEELPYSLSPEQTLNGSIDNIHKDGAVYGDLHKEV
GDESKVDPSAIEITTSNKLDRLNHLTMETHSCVANYDHGLDELTIWSPNQSVHGLRTVVGDLFEIPYHKIRVIKTTMGGS
FGAKQEWVLEPVAACCALSVGKPVKLVYNRAESMVSVYGRGAVESKITSKITKDGKLQSFTTDITLDAGAYLGNSYVYIN
TMLGKFFRCYKYPYVDFTARTTCTNTPVSGGFRGWSGPEATLMIEHNLNVAAKRLNIDPVELRLKNVALPGDKDIYIDRD
LGEIRLKESLELGREKFNWELRKKEVSEFNSKNNRYKRGIGVACGGHVNGFTPKRGEFATVDMRMTEDGSIQANVTLHDH
GCGTVTTFQMIVAEELGIPLDMVSVKEGDTFVSPYDYGCYSSRTVYVLGRAAQECAKEIKRVLGKNIAELHNIPLEDIEV
VNGYVRSKKDEEINYTYAEASVKSLFELGKEVVATYQHKDDTNPSVTAAHFALVEVDTYTGMTKTLDYLAVHDIGKALNR
EMCIAQIEGSVTMGMGAAISEHLTVSEQGQSTNSMKDYHVVNCYDAPNVRVELIEDGGTDGPYGAKSIGEIAHIPVTATI
VGAINDALSTEICEIPINPDKIAKLMSGRA

Sequences:

>Translated_750_residues
MQIIGSSYPTHDAKGKATGQTAYAGDMQLAGMLHAAVLFSPIPHGYVKSIDDSKALALPGVVKVLHCFNTTQKEFSRYRT
FVGQPVPDQERVFNNHVRFVGDRVAAVIAETEEIARKAVELIEVTYEELPYSLSPEQTLNGSIDNIHKDGAVYGDLHKEV
GDESKVDPSAIEITTSNKLDRLNHLTMETHSCVANYDHGLDELTIWSPNQSVHGLRTVVGDLFEIPYHKIRVIKTTMGGS
FGAKQEWVLEPVAACCALSVGKPVKLVYNRAESMVSVYGRGAVESKITSKITKDGKLQSFTTDITLDAGAYLGNSYVYIN
TMLGKFFRCYKYPYVDFTARTTCTNTPVSGGFRGWSGPEATLMIEHNLNVAAKRLNIDPVELRLKNVALPGDKDIYIDRD
LGEIRLKESLELGREKFNWELRKKEVSEFNSKNNRYKRGIGVACGGHVNGFTPKRGEFATVDMRMTEDGSIQANVTLHDH
GCGTVTTFQMIVAEELGIPLDMVSVKEGDTFVSPYDYGCYSSRTVYVLGRAAQECAKEIKRVLGKNIAELHNIPLEDIEV
VNGYVRSKKDEEINYTYAEASVKSLFELGKEVVATYQHKDDTNPSVTAAHFALVEVDTYTGMTKTLDYLAVHDIGKALNR
EMCIAQIEGSVTMGMGAAISEHLTVSEQGQSTNSMKDYHVVNCYDAPNVRVELIEDGGTDGPYGAKSIGEIAHIPVTATI
VGAINDALSTEICEIPINPDKIAKLMSGRA
>Mature_750_residues
MQIIGSSYPTHDAKGKATGQTAYAGDMQLAGMLHAAVLFSPIPHGYVKSIDDSKALALPGVVKVLHCFNTTQKEFSRYRT
FVGQPVPDQERVFNNHVRFVGDRVAAVIAETEEIARKAVELIEVTYEELPYSLSPEQTLNGSIDNIHKDGAVYGDLHKEV
GDESKVDPSAIEITTSNKLDRLNHLTMETHSCVANYDHGLDELTIWSPNQSVHGLRTVVGDLFEIPYHKIRVIKTTMGGS
FGAKQEWVLEPVAACCALSVGKPVKLVYNRAESMVSVYGRGAVESKITSKITKDGKLQSFTTDITLDAGAYLGNSYVYIN
TMLGKFFRCYKYPYVDFTARTTCTNTPVSGGFRGWSGPEATLMIEHNLNVAAKRLNIDPVELRLKNVALPGDKDIYIDRD
LGEIRLKESLELGREKFNWELRKKEVSEFNSKNNRYKRGIGVACGGHVNGFTPKRGEFATVDMRMTEDGSIQANVTLHDH
GCGTVTTFQMIVAEELGIPLDMVSVKEGDTFVSPYDYGCYSSRTVYVLGRAAQECAKEIKRVLGKNIAELHNIPLEDIEV
VNGYVRSKKDEEINYTYAEASVKSLFELGKEVVATYQHKDDTNPSVTAAHFALVEVDTYTGMTKTLDYLAVHDIGKALNR
EMCIAQIEGSVTMGMGAAISEHLTVSEQGQSTNSMKDYHVVNCYDAPNVRVELIEDGGTDGPYGAKSIGEIAHIPVTATI
VGAINDALSTEICEIPINPDKIAKLMSGRA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=742, Percent_Identity=25.8760107816712, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI71773480, Length=750, Percent_Identity=24.9333333333333, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI1789230, Length=744, Percent_Identity=30.241935483871, Blast_Score=320, Evalue=3e-88,
Organism=Escherichia coli, GI1789246, Length=797, Percent_Identity=28.1053952321205, Blast_Score=246, Evalue=5e-66,
Organism=Escherichia coli, GI1786478, Length=767, Percent_Identity=25.9452411994785, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17540638, Length=740, Percent_Identity=24.8648648648649, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17539860, Length=763, Percent_Identity=25.0327653997379, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32566215, Length=733, Percent_Identity=23.0559345156889, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737937, Length=670, Percent_Identity=25.8208955223881, Blast_Score=162, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24647193, Length=746, Percent_Identity=23.1903485254692, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24647199, Length=730, Percent_Identity=23.972602739726, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24647195, Length=738, Percent_Identity=23.1707317073171, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24647197, Length=729, Percent_Identity=23.1824417009602, Blast_Score=109, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24647201, Length=748, Percent_Identity=23.2620320855615, Blast_Score=105, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82449; Mature: 82449

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50817 INTEIN_N_TER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIGSSYPTHDAKGKATGQTAYAGDMQLAGMLHAAVLFSPIPHGYVKSIDDSKALALPG
CCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEECHH
VVKVLHCFNTTQKEFSRYRTFVGQPVPDQERVFNNHVRFVGDRVAAVIAETEEIARKAVE
HHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEVTYEELPYSLSPEQTLNGSIDNIHKDGAVYGDLHKEVGDESKVDPSAIEITTSNKLD
HHHHHHHHCCCCCCCCHHCCCCHHHHCCCCCEECHHHHHCCCCCCCCCCEEEEECCCCHH
RLNHLTMETHSCVANYDHGLDELTIWSPNQSVHGLRTVVGDLFEIPYHKIRVIKTTMGGS
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
FGAKQEWVLEPVAACCALSVGKPVKLVYNRAESMVSVYGRGAVESKITSKITKDGKLQSF
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEE
TTDITLDAGAYLGNSYVYINTMLGKFFRCYKYPYVDFTARTTCTNTPVSGGFRGWSGPEA
EEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCCCCCCE
TLMIEHNLNVAAKRLNIDPVELRLKNVALPGDKDIYIDRDLGEIRLKESLELGREKFNWE
EEEEEECCCEEEEECCCCHHHEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHH
LRKKEVSEFNSKNNRYKRGIGVACGGHVNGFTPKRGEFATVDMRMTEDGSIQANVTLHDH
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECC
GCGTVTTFQMIVAEELGIPLDMVSVKEGDTFVSPYDYGCYSSRTVYVLGRAAQECAKEIK
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHH
RVLGKNIAELHNIPLEDIEVVNGYVRSKKDEEINYTYAEASVKSLFELGKEVVATYQHKD
HHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
DTNPSVTAAHFALVEVDTYTGMTKTLDYLAVHDIGKALNREMCIAQIEGSVTMGMGAAIS
CCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHEEEEECCCEEECCCHHHH
EHLTVSEQGQSTNSMKDYHVVNCYDAPNVRVELIEDGGTDGPYGAKSIGEIAHIPVTATI
HCCEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCEEECCCHHHH
VGAINDALSTEICEIPINPDKIAKLMSGRA
HHHHHHHHCCCEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQIIGSSYPTHDAKGKATGQTAYAGDMQLAGMLHAAVLFSPIPHGYVKSIDDSKALALPG
CCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEECHH
VVKVLHCFNTTQKEFSRYRTFVGQPVPDQERVFNNHVRFVGDRVAAVIAETEEIARKAVE
HHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEVTYEELPYSLSPEQTLNGSIDNIHKDGAVYGDLHKEVGDESKVDPSAIEITTSNKLD
HHHHHHHHCCCCCCCCHHCCCCHHHHCCCCCEECHHHHHCCCCCCCCCCEEEEECCCCHH
RLNHLTMETHSCVANYDHGLDELTIWSPNQSVHGLRTVVGDLFEIPYHKIRVIKTTMGGS
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
FGAKQEWVLEPVAACCALSVGKPVKLVYNRAESMVSVYGRGAVESKITSKITKDGKLQSF
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEE
TTDITLDAGAYLGNSYVYINTMLGKFFRCYKYPYVDFTARTTCTNTPVSGGFRGWSGPEA
EEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCCCCCCE
TLMIEHNLNVAAKRLNIDPVELRLKNVALPGDKDIYIDRDLGEIRLKESLELGREKFNWE
EEEEEECCCEEEEECCCCHHHEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHH
LRKKEVSEFNSKNNRYKRGIGVACGGHVNGFTPKRGEFATVDMRMTEDGSIQANVTLHDH
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECC
GCGTVTTFQMIVAEELGIPLDMVSVKEGDTFVSPYDYGCYSSRTVYVLGRAAQECAKEIK
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHH
RVLGKNIAELHNIPLEDIEVVNGYVRSKKDEEINYTYAEASVKSLFELGKEVVATYQHKD
HHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
DTNPSVTAAHFALVEVDTYTGMTKTLDYLAVHDIGKALNREMCIAQIEGSVTMGMGAAIS
CCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHEEEEECCCEEECCCHHHH
EHLTVSEQGQSTNSMKDYHVVNCYDAPNVRVELIEDGGTDGPYGAKSIGEIAHIPVTATI
HCCEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCEEECCCHHHH
VGAINDALSTEICEIPINPDKIAKLMSGRA
HHHHHHHHCCCEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]