Click here to switch to the map view.

The map label for this gene is mtnA

Identifier: 188585058

GI number: 188585058

Start: 436953

End: 437996

Strand: Direct

Name: mtnA

Synonym: Nther_0419

Alternate gene names: 188585058

Gene position: 436953-437996 (Clockwise)

Preceding gene: 188585056

Following gene: 188585059

Centisome position: 13.8

GC content: 35.82

Gene sequence:

>1044_bases
TTGGTTTCTGTGAAACCACTTAAATTTGAGGATGATGAGCTGCTTTTGTTAGACCAACGAAAATTACCTGGTAAGGAAGA
ATACTTTACATGTAAAACTTATCAAGATGTTCACTTTGCTATTAAAGAAATGGTTTGTAGAGGTGCTCCATTAATAGGGG
CTGTAGGTGCTTATGGTGTTGCTTTGGCTTGCCGTGAATTTATCAATGAATCTCAAGAAAAATTTCAACAAGAAACCAAG
AGAGCGATATCTGAACTATCATCTGCTCGTCCTACAGCTGTGAATTTATTTTGGGCGCTGAATAAAATGAATAAATTATT
GGGTCAAGTTATGGAAGAAAATACAGCCCCTGAAGATATTTATCCTATAATTTTAAATGAAGCCCATAAAATTAGTGATC
AGGAATTGCAAAGAAATTATCGCATTGCTGAATTTGGTGATCAAGTAATTTCAAATGGAGATAAAATCCTGACACATTGT
AATACAGGAGCGTTGGCCACTACTGGTTACGGTACTGCCTTAGGAGTTATTAGACAAGCCCATTATAATCATAAAGACAT
TTTTGTTTATGTTGATGAAACAAGACCAAGATTACAGGGCGCTAAGTTAACTGCTTGGGAATTAAAACAAGAACAATTAC
CCTTTGCATTGATTCCGGATTCTTCGGCTGCCGTTTTAATCAAAAATGGGGATATTGATGTAATATTTGTTGGTGCTGAC
AGAATTGCATCTAATGGTGACACAGCTAATAAAATTGGAACCTTTATGTTATCGATTTTGGCTAAAAAATATAAGGTCCC
ATTTTATGTGGTGGCACCTGTGTCAACTATTGATTTTCAGGCTAAAAACGGTGATGATATAACTATAGAAGAGCGAAGTA
GCAAGGAAGTAACAGAAATAGACGGAGTGCGGGTAGCTCCTACGGACATACAAGTTTATAATCCAGCCTTTGATATCACA
CCAGCTGAAAATATAACAGGTATTATTACAGAAAAAGGAATTATTGGACCAAATAACAGAGAAATCATGACAATTCAGGA
GTAA

Upstream 100 bases:

>100_bases
TTATTTTTACCATTTTTAATTATACAAAAGGAGAACGGTTTTGGAAATAGTACTGTTATTAAATAAATACAAAAAGTAAA
CATAGATTGGAGGGATAATA

Downstream 100 bases:

>100_bases
GTGATTGCTGATGTCGATAGATTGAAAATTTCTCTTTTTTAATTAGTAAAAAACTGATATACTATCTATGACGTACAAAT
ATCTTTATGCACCGATATGC

Product: translation initiation factor 2B subunit I family (IF-2BI)

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MVSVKPLKFEDDELLLLDQRKLPGKEEYFTCKTYQDVHFAIKEMVCRGAPLIGAVGAYGVALACREFINESQEKFQQETK
RAISELSSARPTAVNLFWALNKMNKLLGQVMEENTAPEDIYPIILNEAHKISDQELQRNYRIAEFGDQVISNGDKILTHC
NTGALATTGYGTALGVIRQAHYNHKDIFVYVDETRPRLQGAKLTAWELKQEQLPFALIPDSSAAVLIKNGDIDVIFVGAD
RIASNGDTANKIGTFMLSILAKKYKVPFYVVAPVSTIDFQAKNGDDITIEERSSKEVTEIDGVRVAPTDIQVYNPAFDIT
PAENITGIITEKGIIGPNNREIMTIQE

Sequences:

>Translated_347_residues
MVSVKPLKFEDDELLLLDQRKLPGKEEYFTCKTYQDVHFAIKEMVCRGAPLIGAVGAYGVALACREFINESQEKFQQETK
RAISELSSARPTAVNLFWALNKMNKLLGQVMEENTAPEDIYPIILNEAHKISDQELQRNYRIAEFGDQVISNGDKILTHC
NTGALATTGYGTALGVIRQAHYNHKDIFVYVDETRPRLQGAKLTAWELKQEQLPFALIPDSSAAVLIKNGDIDVIFVGAD
RIASNGDTANKIGTFMLSILAKKYKVPFYVVAPVSTIDFQAKNGDDITIEERSSKEVTEIDGVRVAPTDIQVYNPAFDIT
PAENITGIITEKGIIGPNNREIMTIQE
>Mature_347_residues
MVSVKPLKFEDDELLLLDQRKLPGKEEYFTCKTYQDVHFAIKEMVCRGAPLIGAVGAYGVALACREFINESQEKFQQETK
RAISELSSARPTAVNLFWALNKMNKLLGQVMEENTAPEDIYPIILNEAHKISDQELQRNYRIAEFGDQVISNGDKILTHC
NTGALATTGYGTALGVIRQAHYNHKDIFVYVDETRPRLQGAKLTAWELKQEQLPFALIPDSSAAVLIKNGDIDVIFVGAD
RIASNGDTANKIGTFMLSILAKKYKVPFYVVAPVSTIDFQAKNGDDITIEERSSKEVTEIDGVRVAPTDIQVYNPAFDIT
PAENITGIITEKGIIGPNNREIMTIQE

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=346, Percent_Identity=39.5953757225434, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI23943880, Length=340, Percent_Identity=34.1176470588235, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4503503, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=41.1411411411411, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17557123, Length=200, Percent_Identity=30, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=393, Percent_Identity=36.3867684478371, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322878, Length=218, Percent_Identity=29.3577981651376, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357667, Length=353, Percent_Identity=40.2266288951841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24651647, Length=353, Percent_Identity=40.2266288951841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21358605, Length=222, Percent_Identity=25.2252252252252, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_NATTJ (B2A5S2)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916603.1
- ProteinModelPortal:   B2A5S2
- SMR:   B2A5S2
- GeneID:   6317113
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0419
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38588; Mature: 38588

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: ACT_SITE 240-240 BINDING 90-90 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVKPLKFEDDELLLLDQRKLPGKEEYFTCKTYQDVHFAIKEMVCRGAPLIGAVGAYGV
CCCCCCCEECCCCEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALACREFINESQEKFQQETKRAISELSSARPTAVNLFWALNKMNKLLGQVMEENTAPEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCE
YPIILNEAHKISDQELQRNYRIAEFGDQVISNGDKILTHCNTGALATTGYGTALGVIRQA
EEEEECCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHH
HYNHKDIFVYVDETRPRLQGAKLTAWELKQEQLPFALIPDSSAAVLIKNGDIDVIFVGAD
CCCCCEEEEEEECCCCCCCCCEEEHHHHHHHCCCEEEECCCCCEEEEECCCEEEEEEECC
RIASNGDTANKIGTFMLSILAKKYKVPFYVVAPVSTIDFQAKNGDDITIEERSSKEVTEI
HHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCEEEEECCCCCCHHHC
DGVRVAPTDIQVYNPAFDITPAENITGIITEKGIIGPNNREIMTIQE
CCEEECCCCEEEECCEECCCCCCCCEEEEEECCEECCCCCEEEEEEC
>Mature Secondary Structure
MVSVKPLKFEDDELLLLDQRKLPGKEEYFTCKTYQDVHFAIKEMVCRGAPLIGAVGAYGV
CCCCCCCEECCCCEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALACREFINESQEKFQQETKRAISELSSARPTAVNLFWALNKMNKLLGQVMEENTAPEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCE
YPIILNEAHKISDQELQRNYRIAEFGDQVISNGDKILTHCNTGALATTGYGTALGVIRQA
EEEEECCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHH
HYNHKDIFVYVDETRPRLQGAKLTAWELKQEQLPFALIPDSSAAVLIKNGDIDVIFVGAD
CCCCCEEEEEEECCCCCCCCCEEEHHHHHHHCCCEEEECCCCCEEEEECCCEEEEEEECC
RIASNGDTANKIGTFMLSILAKKYKVPFYVVAPVSTIDFQAKNGDDITIEERSSKEVTEI
HHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCEEEEECCCCCCHHHC
DGVRVAPTDIQVYNPAFDITPAENITGIITEKGIIGPNNREIMTIQE
CCEEECCCCEEEECCEECCCCCCCCEEEEEECCEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA