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The map label for this gene is moeB [H]

Identifier: 188585048

GI number: 188585048

Start: 428242

End: 429126

Strand: Reverse

Name: moeB [H]

Synonym: Nther_0409

Alternate gene names: 188585048

Gene position: 429126-428242 (Counterclockwise)

Preceding gene: 188585049

Following gene: 188585046

Centisome position: 13.56

GC content: 35.93

Gene sequence:

>885_bases
GTGCCAAATAACACAAATAATAATTTGATTGAAGATTTACATAATGTAAAGACCCAAGCTTCAGCTGGTAGTGCTAATCT
TAATGTCATCACAGTGGAAAATGAATTACAAATAGCCGAAGACAATCAAGTGACTACTAAAAAGGTACAACAAATATCCT
TAAAGGAACAAATTTTACCTACTAGATATTTAAGAAATTACGGAACTATGGGATTTGAAGGCCAGTCAGCATTATTAAAA
TCTTCAGTAGGCATAATAGGAGCTGGAGGTCTAGGTGGAACCATAGCTGAATTACTTGCAAGAATGGGAGTGGGCCATTT
AGTTTTAATTGATAACGACCAATTTGAAGACAACAATTTAAATCGCCAGGTCCTATCTCAAGAAAGCAATTTAGGGGAAA
CAAAAGTTTCAGCTGCTTACACTAGAATCACAAATATTAATTCGGCAGTTTCCGTCTCTCCTTATACATTAAAGCTTAAT
TCAAATAATGCCCCGGAATTACTTGCAGATTGCGATATATTAATTGATGCTTTGGATAATATGAGCACACGTTTTATTTT
ACAAAAAACAGCTAGAGAACTTGAAATACCCATGGTACATGGAGCCATTGGAGGATTTTCTGGTCAGGTAACTACAATTC
TACCAAATGATCGAGGACTAGAGACCCTATACTCCAGTCTATTGGAAACTGATTCGGAGCAATATCAATATCCTGACAAA
CTAGCAGAGGTTGAACTCGGAAACCCTTCCGCTACACCAGCTATAGTTGCATCTTGGCAGACTCAAGAAGCAATCAAATT
TTTAACTAATAAAGGAGATTTGTTACGGCATCGATTATTATATTTGGACTCATATACAGGGAATGCTGAAATAATCAAAT
ACTAA

Upstream 100 bases:

>100_bases
CACAGAAGAAGAATAACAAATCGTATATTTTCAGTTATATTTCTTAGTTATCCTTGAAAGTATGTTCTATTATTCTTTTA
CAAAGGAGGTGAAATCAGTA

Downstream 100 bases:

>100_bases
TTAATAACGAAATATTATATATTCATATACTAAAACCGCCCACTTAGGGCGGTTTGATTTTTTATTGGGATTCTACTAAA
TTGTGTATTATAACTTCTAC

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MPNNTNNNLIEDLHNVKTQASAGSANLNVITVENELQIAEDNQVTTKKVQQISLKEQILPTRYLRNYGTMGFEGQSALLK
SSVGIIGAGGLGGTIAELLARMGVGHLVLIDNDQFEDNNLNRQVLSQESNLGETKVSAAYTRITNINSAVSVSPYTLKLN
SNNAPELLADCDILIDALDNMSTRFILQKTARELEIPMVHGAIGGFSGQVTTILPNDRGLETLYSSLLETDSEQYQYPDK
LAEVELGNPSATPAIVASWQTQEAIKFLTNKGDLLRHRLLYLDSYTGNAEIIKY

Sequences:

>Translated_294_residues
MPNNTNNNLIEDLHNVKTQASAGSANLNVITVENELQIAEDNQVTTKKVQQISLKEQILPTRYLRNYGTMGFEGQSALLK
SSVGIIGAGGLGGTIAELLARMGVGHLVLIDNDQFEDNNLNRQVLSQESNLGETKVSAAYTRITNINSAVSVSPYTLKLN
SNNAPELLADCDILIDALDNMSTRFILQKTARELEIPMVHGAIGGFSGQVTTILPNDRGLETLYSSLLETDSEQYQYPDK
LAEVELGNPSATPAIVASWQTQEAIKFLTNKGDLLRHRLLYLDSYTGNAEIIKY
>Mature_293_residues
PNNTNNNLIEDLHNVKTQASAGSANLNVITVENELQIAEDNQVTTKKVQQISLKEQILPTRYLRNYGTMGFEGQSALLKS
SVGIIGAGGLGGTIAELLARMGVGHLVLIDNDQFEDNNLNRQVLSQESNLGETKVSAAYTRITNINSAVSVSPYTLKLNS
NNAPELLADCDILIDALDNMSTRFILQKTARELEIPMVHGAIGGFSGQVTTILPNDRGLETLYSSLLETDSEQYQYPDKL
AEVELGNPSATPAIVASWQTQEAIKFLTNKGDLLRHRLLYLDSYTGNAEIIKY

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=160, Percent_Identity=36.875, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4885649, Length=138, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787048, Length=215, Percent_Identity=32.5581395348837, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082356, Length=156, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1789177, Length=150, Percent_Identity=31.3333333333333, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=226, Percent_Identity=28.7610619469027, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321903, Length=151, Percent_Identity=36.4238410596026, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320598, Length=148, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582879, Length=263, Percent_Identity=29.277566539924, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24660640, Length=165, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 32142; Mature: 32010

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNNTNNNLIEDLHNVKTQASAGSANLNVITVENELQIAEDNQVTTKKVQQISLKEQILP
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHH
TRYLRNYGTMGFEGQSALLKSSVGIIGAGGLGGTIAELLARMGVGHLVLIDNDQFEDNNL
HHHHHHCCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
NRQVLSQESNLGETKVSAAYTRITNINSAVSVSPYTLKLNSNNAPELLADCDILIDALDN
CHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHC
MSTRFILQKTARELEIPMVHGAIGGFSGQVTTILPNDRGLETLYSSLLETDSEQYQYPDK
CHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCCH
LAEVELGNPSATPAIVASWQTQEAIKFLTNKGDLLRHRLLYLDSYTGNAEIIKY
HHEEECCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHEEECCCCCEEEEEC
>Mature Secondary Structure 
PNNTNNNLIEDLHNVKTQASAGSANLNVITVENELQIAEDNQVTTKKVQQISLKEQILP
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHH
TRYLRNYGTMGFEGQSALLKSSVGIIGAGGLGGTIAELLARMGVGHLVLIDNDQFEDNNL
HHHHHHCCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
NRQVLSQESNLGETKVSAAYTRITNINSAVSVSPYTLKLNSNNAPELLADCDILIDALDN
CHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHC
MSTRFILQKTARELEIPMVHGAIGGFSGQVTTILPNDRGLETLYSSLLETDSEQYQYPDK
CHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCCH
LAEVELGNPSATPAIVASWQTQEAIKFLTNKGDLLRHRLLYLDSYTGNAEIIKY
HHEEECCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA