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The map label for this gene is mrdA [H]

Identifier: 188528357

GI number: 188528357

Start: 1589798

End: 1591573

Strand: Reverse

Name: mrdA [H]

Synonym: HPSH_08155

Alternate gene names: 188528357

Gene position: 1591573-1589798 (Counterclockwise)

Preceding gene: 188528358

Following gene: 188528354

Centisome position: 98.94

GC content: 41.05

Gene sequence:

>1776_bases
ATGAAAAATCTTCGCTATAAGCTTTTGCTCTTTGTTTTTATAGGGTTTTGGGGGTTATTGGTTTTAAATTTATTTATTTT
AAGCGTTAAAAATCAAGAATACTATGAAAAACTGGCTGAACGAAACATGACTAAAAAGGAATTTCTAGTCCCTACAAGGG
GTAATATTACAGACAGAAACCATGAGTTTTTAGCCACTAATGAATTGGTGTTTGGCGTGTTTTTGCCCAGCGGATTGAAA
CAAAAAGAGCTTTTAGAAAAAATTGAAATCATCCAAAAGTTTTTCCCTAACTTTTCCAAAGAAACGCTTTTAAACAATTA
CCAAAAGGAAAATTCGCTTTATAACCACAACCTTATTAAAGTGGTTGGTTTCATTCCTTATATTACCATGCAACCTCTTT
ATACCAAACTCATCCAAACTCAGGGCATTTTTGCGCTTCCCTTAGACAAGCGCTACTACCCTAATAACGCTTTAGCTTCA
CATGTTTTAGGCTATGTGGGGGTGGCAAGCTTGCAAGATTTGAAAGACGATGAAGAGAATCAATACAGCCAGATTGTGGG
CAAAACCGGCGTTGAAAAAGAATACAACAAGCTCTTACAAGGCAAGGTGGGCTATAAAATCATGCGCGTCAATGCGCTCA
ATCAAGAATTAGCCACCTTAGAAGTAGTGCCACCAAGCACCAACAACCACTTGCAATTGAGTTTAGACAAACGCTTGCAA
AAAGAAGCGGACAAGCTCTTTGAAAATAAAAGGGGGGCTATTTTAGTGATGGATGCAGAAAATGGGGAATTGCTCGTTGC
AGGAAGTTACCCTGAATACAATTTGAACGATTTTGTAGGCGGGATCAGTCAAGACAAATGGCAAAAACTTCAAGATGATA
TTTATAACCCCCTACTAAACCGCTTCGCTAACGCCTTATACCCGCCGGGATCTGTGGTTAAAATGGGCGTGGGCTTGAGC
TTTTTAGAAAACCTTAATATCACAGAAAACACCACCATACCCACACCGCCTTTTATTGAAGTGGGCAAGCGCAAATTCAG
AGATTGGAAAAAAACAGGGCATGGCAATTCTAATTTATATAAAGCCATTAGGGAGTCCGTGGATGTGTATTTTTATAAGT
TTGGGCTTGAAATTTCTATAGAAAAACTCTCTAAAACCTTAAGGGAAGTGGGCTTTGGGGAAAAAACGGGCGTTGATTTG
CCGAATGAATTTGTGGGGATTGTGCCGGATAATTTGTGGAAACTCAAACGCTTCAATCAAGATTGGCGCGTTGGGGACAC
GCTCATTACCGCTATTGGGCAAGGCTCTTTTTTGGCCACGCCCTTGCAGGTTTTAGCCTACACGGGACTCATTGCTACGG
GCAAACTGGCAACGCCTCATTTCGCTATCAACAACAAACAACCGCTCAAAGATCCCCTAAATAGCTTTCAAAAAAAGAAG
CTCCAAGCCTTGAGAGTGGGCATGTATGAAGTGTGTAACCATAAAGACGGCACCGCTTATCATTCCACAAGGGGTTCTAA
GGTTACTTTAGCGTGTAAAACCGGCACCGCGCAAGTCGTGGAAATCGCTCAAAACATCGTCAATCGCATGAAAGAAAAGG
ATATGGAATATTTCCATCGATCCCATGCGTGGATTACCGCCTTTTTGCCCTATGAAAAACCCAAATACGCTATCACCATT
TTAGTAGAACATGGGGAAGGGGGTTCAAAACTGGGGGGCTTGTTAGTGGAAATGAGTAACAAACTCTATGAGCTTGGCTA
TCTTAACCAATTGTAA

Upstream 100 bases:

>100_bases
TACCTTTATTTATCGCGCTTTTTTTCTGTGTCTTTGAGTTTGAAAATACTCGGCTTTCTCGCTCTTTTTGCTTTAATAGA
GAGCGCTTTGTGGGGTTTGT

Downstream 100 bases:

>100_bases
CTGGCTCACACAAGATTTTTATGGGAATGAACGCCCTTTATCCTAAGATAAAGAGGCGTTTTTGCGTTTAAAAAGCCGGG
ATAATCGCCCCTTTATAGGT

Product: penicillin-binding protein 2 (pbp2)

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPSGLK
QKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYITMQPLYTKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGVEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVEMSNKLYELGYLNQL

Sequences:

>Translated_591_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPSGLK
QKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYITMQPLYTKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGVEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVEMSNKLYELGYLNQL
>Mature_591_residues
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNHEFLATNELVFGVFLPSGLK
QKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYITMQPLYTKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGVEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVEMSNKLYELGYLNQL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=30.2931596091205, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1786272, Length=449, Percent_Identity=22.71714922049, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67249; Mature: 67249

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
HEFLATNELVFGVFLPSGLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHH
VVGFIPYITMQPLYTKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGVEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEECCCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVEMSNKLYELGYLNQL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
HEFLATNELVFGVFLPSGLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHH
VVGFIPYITMQPLYTKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGVEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEECCCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVEMSNKLYELGYLNQL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]