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The map label for this gene is copA [H]

Identifier: 188528273

GI number: 188528273

Start: 1494302

End: 1496638

Strand: Reverse

Name: copA [H]

Synonym: HPSH_07715

Alternate gene names: 188528273

Gene position: 1496638-1494302 (Counterclockwise)

Preceding gene: 188528274

Following gene: 188528271

Centisome position: 93.04

GC content: 39.2

Gene sequence:

>2337_bases
ATGAAATGTTCGCATTGCCAGTTGGAGTTTAAAGAAAGTGAGCTTTTTAAAGAGGTGATCAATCATAAAGAATTGTATTT
TTGCTGCACGGGGTGCGCTAGGGTGTATGCGTTATTGTCAGATTTGAATTTAGAGAGCTTTTATGACAAATTAAACGATT
CCACTTTAGCCCCCGTAAAACCCCAAGATTCAATGAGCGCTTTAGAATTAGAACAGGCCCTTGAAGAAAACAATAAAAGC
GATTTTATCCTTAATCTTTTGTTGGAAAAAACGCATTGTAACGCTTGCTTGTGGCTCAATCAAAAGGTTTTAGAGCGCTT
AAAGGGGGTTAAAAAAGTGAGCGTGAATTTCACCACCCACCATTTGCAAATCGTGTTTGACAAGTCTTTAAACCCTAAAG
AGATCGTTCAAAAAATTGAGAGTTTGGGCTATGGGGCTAAAATTTATAACGCAAAAAATTACGCTCTAAAAGCCCAAAAA
GAGCAACGCTCCTATTTGCTCACTTTAAGCGTGGGGTTTTTTGCCACCATGAATTTGATGTTTATTGCAATTGCCAAATA
CGCGAGTTATGGCGCTGGCATGGATAAGCTCATGCAAAGGAATTTGGATCTCGTGTCGCTCTTTTTAAGCTTGTTGGTGC
TAGTGGTTGTGGGGCGTTTTTTCATTAAGGGGGCGTTTTATGGGCTAAAAAATGGCGTTTTGGGCATGGATTTGAGCGTG
TCTTTTGGAGCGTTATCGGCGTTTGTTTATTCTATTTATGCCATGTTGGTGTCCCAAGAGACTTATTTTGAAGCGAGCAG
CACGATTTTAACGCTTGTTTTTGGCTCTAAGTTTTTGGAATTAAAGGCCAGGCTGTTTGCGAATGAAAAATGTCTGGCCC
TAGAATCGCATGAAATCCATAGCGTGATCGTTGTAGAAAATGGCAAGCAAATAGAAAAACACCCTAAAGATGTCGCTATA
GGCTCTGTTGTTTTGGTGCCAAGCGGGGCTAAAATCGCTTTAGATGGTGCGCTTTTAAACCATGCGAGCGTGGATGCGTC
TTTGATCAGTGGGGAATTTAAGCCTTTGGAATTGGGGGTTAATGATCAAATTTTAGGGGGTTATGTGAATGTGGGTGCGC
CTTTTAGCTATCAAGTGAGCGCTAATTTTCAAAACTCACGCCTTTCTAGCTTGTTAGAAATTTTAAAAAAGAGTTTTTTA
GAAAAGCCCTTAATTGAGAGCAGCGCGAACAAAATTGCGGATATTTTTTCTAAAGCGGTGCTGTTTTTAGCCTTTATAAG
CTTTTTATTATGGCAATTTGGTTTGGGGGGTAATTTTGAAAAAGCCTTAATGGTGTGCATTAGCGTGTTAGTCATCAGCT
GCCCTTGCGCGTTCGCTTTGGCTACGCCCATTGCGTTAGTGATAGGGGTGTTTAAAAACCCTTTGATCGTGTTTAAAGAA
GCGTTGTTTTTAGAAACTCTGGCTAAAGTGAAAAAAATCTTTATAGACAAAACCGGCACGCTCACGCAAAAAGAAGTCCT
TTTAAAAGAAAAAATCATTTATGAAGAATTTGACGAAAGGCTTTTAAAGAGCCTTTTAAAAGTGAGAGAGCATTTAGCCC
ATAGCGCGATCCTTAAATCTCTAGATAGCGATGAGGTTCATTTAGAAAAGATAGAGTTTTTCGCTCATGGCCTGAAAGCG
AATTATCATAATGAAACTTTGCTGGTGGGGAGTTTGAAATTTTTAAACGCTATGGGGGTTAATATAAAGGCTAAAGAGAG
CGCTAATATCATGGTAGGCTTTGCGAAAAATAAGACCTTATGCGCGTTATTCGTTTTAGAAGAGCGTTTGAAAAATAACG
CTAAAGAAGTTATTCAGGCTTTACAAGATAAAGGCTTAGAATTAGAAATTTTAAGCGGGGATAATGAAAACTCGGTTAAG
GAGTGCGCGAAAAAATTAGGGATTTCTAATTATCATGCCAATTTGACCCCTGAAGATAAGGCTCAAATCATCAGTTCTTA
TAAGGGCGTGTGCGCGATGATAGGCGATGGCAATAATGACGCATTAGCCTTAAAACAAGCGAGCGTTTCTTTAGGGTTTG
AAAAAAGCGCTTTGAGTAAAAGCGCATGCGATATTTTGCTTTTAGAAGAGGATTTGAGTTTGCTAAAAAAAGCGTTTGAT
AACGCTCAAAAAGTCTATCAAGTGGTGTTGCAAAACATTGTTTTGAGCTTGATTTATAACGCTATTTTAATCCCGGTCGC
TATGCTAGGATACATTAACCCTTTAATAGCGAGTTTGAGCATGAGTGCGAGTTCGCTCTTAGTGGTCTTAAATTCTTTGA
GGTTGAAACGCTCTTAA

Upstream 100 bases:

>100_bases
AGCGACAACACCAAAGAAGTTCTAAGTATCTATCAAATTTGTAACACTTATTCTATCAAAGCGCTTTTAAATTAGCGTCT
CATCAATTAAGGATTAAGAC

Downstream 100 bases:

>100_bases
ACAAACCACATCGTTTTGGCTAAAATGGCAATTAAAAAACCAAAAGTTAGAGCGATAGGGTGGATATATTTACCAATGGG
GTTTTTCTTACCCAAAAACT

Product: putative cation transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MKCSHCQLEFKESELFKEVINHKELYFCCTGCARVYALLSDLNLESFYDKLNDSTLAPVKPQDSMSALELEQALEENNKS
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSV
SFGALSAFVYSIYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQIEKHPKDVAI
GSVVLVPSGAKIALDGALLNHASVDASLISGEFKPLELGVNDQILGGYVNVGAPFSYQVSANFQNSRLSSLLEILKKSFL
EKPLIESSANKIADIFSKAVLFLAFISFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKE
ALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDERLLKSLLKVREHLAHSAILKSLDSDEVHLEKIEFFAHGLKA
NYHNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFVLEERLKNNAKEVIQALQDKGLELEILSGDNENSVK
ECAKKLGISNYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFD
NAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Sequences:

>Translated_778_residues
MKCSHCQLEFKESELFKEVINHKELYFCCTGCARVYALLSDLNLESFYDKLNDSTLAPVKPQDSMSALELEQALEENNKS
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSV
SFGALSAFVYSIYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQIEKHPKDVAI
GSVVLVPSGAKIALDGALLNHASVDASLISGEFKPLELGVNDQILGGYVNVGAPFSYQVSANFQNSRLSSLLEILKKSFL
EKPLIESSANKIADIFSKAVLFLAFISFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKE
ALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDERLLKSLLKVREHLAHSAILKSLDSDEVHLEKIEFFAHGLKA
NYHNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFVLEERLKNNAKEVIQALQDKGLELEILSGDNENSVK
ECAKKLGISNYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFD
NAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
>Mature_778_residues
MKCSHCQLEFKESELFKEVINHKELYFCCTGCARVYALLSDLNLESFYDKLNDSTLAPVKPQDSMSALELEQALEENNKS
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSV
SFGALSAFVYSIYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQIEKHPKDVAI
GSVVLVPSGAKIALDGALLNHASVDASLISGEFKPLELGVNDQILGGYVNVGAPFSYQVSANFQNSRLSSLLEILKKSFL
EKPLIESSANKIADIFSKAVLFLAFISFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKE
ALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDERLLKSLLKVREHLAHSAILKSLDSDEVHLEKIEFFAHGLKA
NYHNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFVLEERLKNNAKEVIQALQDKGLELEILSGDNENSVK
ECAKKLGISNYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFD
NAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=789, Percent_Identity=22.1799746514575, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI115529486, Length=509, Percent_Identity=24.1650294695481, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI55743073, Length=493, Percent_Identity=23.1237322515213, Blast_Score=116, Evalue=8e-26,
Organism=Escherichia coli, GI1786691, Length=834, Percent_Identity=26.4988009592326, Blast_Score=238, Evalue=2e-63,
Organism=Escherichia coli, GI1789879, Length=704, Percent_Identity=23.5795454545455, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1786914, Length=425, Percent_Identity=24.9411764705882, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=438, Percent_Identity=23.7442922374429, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319772, Length=630, Percent_Identity=27.9365079365079, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320475, Length=759, Percent_Identity=24.2424242424242, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI221329854, Length=478, Percent_Identity=23.8493723849372, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 85958; Mature: 85958

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSHCQLEFKESELFKEVINHKELYFCCTGCARVYALLSDLNLESFYDKLNDSTLAPVK
CCCCCCCEECHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMSALELEQALEENNKSDFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTH
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHEECCCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSV
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SFGALSAFVYSIYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIH
HHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCE
SVIVVENGKQIEKHPKDVAIGSVVLVPSGAKIALDGALLNHASVDASLISGEFKPLELGV
EEEEEECCCHHHHCCCCEEECEEEEECCCCEEEECHHHHCCCCCCHHHHCCCCCEEEECC
NDQILGGYVNVGAPFSYQVSANFQNSRLSSLLEILKKSFLEKPLIESSANKIADIFSKAV
CCCEECCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFLAFISFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
ALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDERLLKSLLKVREHLAHSAILKS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSDEVHLEKIEFFAHGLKANYHNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTL
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCEEECCCCCEEEEEECCCCH
CALFVLEERLKNNAKEVIQALQDKGLELEILSGDNENSVKECAKKLGISNYHANLTPEDK
HHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHH
AQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFD
HHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHHHHHHHHHHHH
NAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKCSHCQLEFKESELFKEVINHKELYFCCTGCARVYALLSDLNLESFYDKLNDSTLAPVK
CCCCCCCEECHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMSALELEQALEENNKSDFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTH
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHEECCCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGAGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSV
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SFGALSAFVYSIYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIH
HHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCE
SVIVVENGKQIEKHPKDVAIGSVVLVPSGAKIALDGALLNHASVDASLISGEFKPLELGV
EEEEEECCCHHHHCCCCEEECEEEEECCCCEEEECHHHHCCCCCCHHHHCCCCCEEEECC
NDQILGGYVNVGAPFSYQVSANFQNSRLSSLLEILKKSFLEKPLIESSANKIADIFSKAV
CCCEECCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LFLAFISFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
ALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEEFDERLLKSLLKVREHLAHSAILKS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSDEVHLEKIEFFAHGLKANYHNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTL
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCEEECCCCCEEEEEECCCCH
CALFVLEERLKNNAKEVIQALQDKGLELEILSGDNENSVKECAKKLGISNYHANLTPEDK
HHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHH
AQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLKKAFD
HHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHHHHHHHHHHHH
NAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA