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The map label for this gene is ubiE

Identifier: 188528254

GI number: 188528254

Start: 1476004

End: 1476744

Strand: Reverse

Name: ubiE

Synonym: HPSH_07600

Alternate gene names: 188528254

Gene position: 1476744-1476004 (Counterclockwise)

Preceding gene: 188528255

Following gene: 188528253

Centisome position: 91.81

GC content: 39.0

Gene sequence:

>741_bases
ATGAAGAAAGAAAAGCACCTCAAGCAAGAAAAAATCATCAACATGTTTGATGATATAGCCAGCTCTTACGATCAAGCCAA
CCGCTTGATGAGTTTTGGCTTAGATGTTAAATGGCGAGAAAGGGCTTGCGAGCATGCGTTTTTGTTTTTGGAAAACAAGA
AAGCCTTAAGGCTTGTGGATGTGGCATGCGGGACGGGGGACATGCTTGTTGCTTGGCAAAAAAGCGCTCTAAATTGCGCT
ATAGAGTTTAAGGAATGTTTGGGGATTGATCCTTCTAATAACATGCTTGAATTAGCCGTTAAAAAATTTGAGAAGCTTGA
AAACAAAGTTTCTTTCATCCAGGCTCAAGCCAAAGATTTAAAAGGCGTTGAAAACAACAGCGTGGATATTCTCTCCATTG
CGTATGGCTTGCGTAATATCGTGGAAAGACAAGAAGCCTTAAAAGAGTTTTTTAGGGTGTTAAAGCCTAGGGGCGTTTTA
GTGATTTTAGAATTTTTAAAAAAGGACAACCCCACATGGCTGGATAAAATTTCAGGGTTTTACACGAATAAGGTTTTGCC
TTTAATGGGAGGGGCTATCAGTAAGAATTATGGCGCTTATTCTTATTTACCGCAATCCATTGAGGGGTTTTTGAGTTTGG
AGGGTTTGAAACATGAATTAAAAAACGCAGGGTTTGAGATTTTAAGAACTGAAGATTCTATCGCTCAAATTTCAACGACC
ATGCTTGTTAGAAAAAGCTAA

Upstream 100 bases:

>100_bases
AAGAAACGCAAGGTTTTATCGTGTGTTTAATGAGATTCCAACGATTTTGATGATCCTCATTGTGATTTTAGTGGTTGTCA
AGCCTTTTTAAAGAAAAGCC

Downstream 100 bases:

>100_bases
AGGAATGCCATGCAAGATGAATTGTTTGAAACCGAAAAAGCCCCCCAAAAAAACACCAAAAACGCTAAAAACGCCCCTAA
AAAAAGCTTTGAAGAGCATG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
IEFKECLGIDPSNNMLELAVKKFEKLENKVSFIQAQAKDLKGVENNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLMGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTEDSIAQISTT
MLVRKS

Sequences:

>Translated_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
IEFKECLGIDPSNNMLELAVKKFEKLENKVSFIQAQAKDLKGVENNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLMGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTEDSIAQISTT
MLVRKS
>Mature_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
IEFKECLGIDPSNNMLELAVKKFEKLENKVSFIQAQAKDLKGVENNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VILEFLKKDNPTWLDKISGFYTNKVLPLMGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTEDSIAQISTT
MLVRKS

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=27.5471698113208, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=30.5309734513274, Blast_Score=107, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=26.530612244898, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323526, Length=232, Percent_Identity=30.6034482758621, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=29.2887029288703, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27962; Mature: 27962

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCAIEFKECLGIDPSNNMLELAVKKFEKLENKVSFIQAQAKDL
EECCCCCEEEEEHHHHHHHHEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGVENNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
YTNKVLPLMGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVRKS
HHEECC
>Mature Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCAIEFKECLGIDPSNNMLELAVKKFEKLENKVSFIQAQAKDL
EECCCCCEEEEEHHHHHHHHEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGVENNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
YTNKVLPLMGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVRKS
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA