| Definition | Helicobacter pylori Shi470, complete genome. |
|---|---|
| Accession | NC_010698 |
| Length | 1,608,548 |
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The map label for this gene is polA [H]
Identifier: 188528242
GI number: 188528242
Start: 1460215
End: 1462896
Strand: Reverse
Name: polA [H]
Synonym: HPSH_07530
Alternate gene names: 188528242
Gene position: 1462896-1460215 (Counterclockwise)
Preceding gene: 209406225
Following gene: 188528241
Centisome position: 90.95
GC content: 38.55
Gene sequence:
>2682_bases ATGGAAGAGCCAGTCATTAAAGAGGGGACTTTAGCGTTAATTGATACTTTTGCGTATTTGTTTAGAAGCTATTACATGAG CGCTAAAAATAAGCCTTTAACCAATGATAAGGGCTTTCCTACAGGGCTTTTAACGGGGCTTGTGGGCATGGTTAAAAAAT TTTATAAAGATAGAAAAAACATGCCTTTTATCGTGTTCGCTCTAGAAAGCCAGACTAAAACTAAAAGGGCTGAAAGATTA GGCGAATACAAACAAAATCGTAAAGACGCCCCTAAAGAGATGCTTTTACAAATCCCTATCGCATTAGAATGGTTGCAAAA AATGGGTTTTACTTGCGTGGAGGTGAGCGGGTTTGAAGCTGATGATGTTATCGCAAGCCTGGCCACGCTAAGCCCTTATA AAACCCGCATTTATTCTAAAGATAAGGATTTTAACCAGCTTTTGAGCGATAAAATCGCGCTTTTTGATGGCAAAACGGAG TTTTTGGCGAAAGATTGCGTGGAAAAATACGGGATTTTGCCGAGTCAATTCACGGATTATCAGGGCATTGTGGGGGATAG CAGCGATAATTACAAGGGGGTTAAAGGCATTGGGAGCAAGAACGCTAAGGAATTGTTACAGCGCTTAGGGAGTTTGGAAA AAATCTATGAAAATTTAGACTTGGCGAAAAATTTACTCAGCCCTAAAATGTATCAAGCCCTTATACAAGACAAAGAGAGC GCGTTTTTAAGCAAAGAATTAGCCACTTTACAAAGAGGATGCATTAAAGAATTTGATTTTTTAAGTTGCGCTTTTCCTAG CGAAAACCCTTTATTGAAAATCAAAGATGAATTGAAAGAATATGGTTTTATTTCTACTTTAAGGGATTTAGAAAATTCCC CTACGCCTTTAATTTTAGACAACACGCCTCTATTAGAAAACGCGCCCCTATTAGACAACGCCCCTAAAAAATCATGCATG ATCGTTTTAGAAAACACCGCGCCTTTGAGCGCGTTTTTAGAAAAATTAGAAAATTCTAACGCTAGGATTTTTATGCGTTT GGTGCTGGATAAAGAAAAAAAAGTTCTGGCCCTAGCGTTTTTATATGAAGATCAAGGCTATTTTTTACCTTTAGAAGAGG CGTTATTTTCGCCCTTTTCTTTAGAATTTTTGCAAAACGCTTTTTTTAAAATGTTACAGCATGCACAAATCATTGGGCAT GATTTAAAACCCTTATTAAGCTTTTTAAAAGCCAAATACCAGGTGTCTTTAGAAAACATTCGCATCCAAGACACTCAAAT TTTAGCGTTTTTAAAAAATCCGGAAAAAGTGGGGTTTGATGAAGTTGTAAGGGAATATTTAAAAGAAGAATTGATCCCGC ATGAAACAATCAAAGATTTTAAGACAAAAAGTAGGGTGGAAAAATTAGAGCAATTGGATATGGAATTAAACGCTTTAAAG CGTTTGTGCGAATATTTTGAAAAAGGGGGGCTAGAAGAGGGTTTGCTTGCTTTGGCTAGAGAAGTTGAAACGCCGTTTAT GAAAGTTTTAATGGGTATGGAATTTCAAGGCTTTAAGATTGATGCGCCTTATTTCAAGCGCTTAGAGCAGGAGTTTAAAG ATGAATTGCATGTTTTAGAGCGCCAAATTTTGGATCTAATCGGCGTGGATTTTAACCTCAACTCCCCCAAACAACTCAGC GAGATTTTGTATGAAAAATTAGAGCTTCCTCAAAATAAAAGCCGTTCTACTGATGAAAAAAGCTTGTTAAAAATCCTAGA CAAGCACCCAAGCATCGCTTTGATTTTAGAATACAGAGAATTGAATAAGCTTTTTAACACTTATACCACCCCCTTATTGC GCCTAAAAGACAAAGACGATAAAATCCATACCACTTTCATCCAAACCGGCACAGCTACCGGGCGTTTAAGCTCGCATTCG CCTAATTTGCAAAATATCCCGGTGCGATCGCCTAAAGGCTTACTCATTCGTAAGGGCTTTATCGCTAGCTCTAAAGAATA TTGTTTGCTAGGGGTGGATTATTCGCAGATTGAATTGCGCTTGTTAGCCCATTTTAGCCAGGATAAGGATTTAATGGATG CGTTTTTAAAGGGGCGAGACATCCATTTAGAAACTTCTAAGGCGTTGTTTGGAGAAGATTTGGCCAAAGAAAAACGATCC ATCGCTAAAAGCATTAATTTTGGGCTGGTGTATGGCATGGGGAGTAAGAAATTGAGCGAAACTTTAAACATCCCTTTAAA TGAGGCTAAAAGCTACATAGAAGCGTATTTCAAACGATTCCCTAGCATTAAAGATTATTTAAACCGCATGAAAGAAGAGA TTTTAAAAACTTCTAAGGCCTTTACTTTGCTTGGGCGTTATCGGGTGTTTGATTTTACCGGCGCAAATGATCACATCAAG GGCAATTATTTGCGAGAGGGCGTGAATGCGATTTTTCAAGGGAGCGCGAGCGATTTATTGAAATTAGGCATGCTCAAAGT GAGCGAGCGTTTCAAAAATAACCCTTCGGTGAGGCTGCTTTTGCAAGTGCATGACGAATTGATTTTTGAGATTGAAGAAA AAAACGCCCCAGAGTTGCAGCAAGAAATCCAACGCATCCTCAATGATGAAGTTTATCCTTTGAGGGTGCCGCTAGAAACG AGTGCGTTTATGGCTAAGCGTTGGAATGAATTAAAAGGGTAG
Upstream 100 bases:
>100_bases AAGAAACGCCAACCCAAAAAGACTCGTTGTTTTGAAACAGATGAGGTCAAGCTTGTGTTACAATAAACTTAAAATTTGCT TGATTGAAGAGGGTTGATGC
Downstream 100 bases:
>100_bases TTTTTTAATTGAGTTTAAGAAAAAATATATTATTATTTCTTTATAAGTAATACTTAGCCATTTTAAGCTAATTATTATAT AAAGTGATTATCAAAAATAA
Product: DNA polymerase I (polA)
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 893; Mature: 893
Protein sequence:
>893_residues MEEPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAERL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKES AFLSKELATLQRGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNTPLLENAPLLDNAPKKSCM IVLENTAPLSAFLEKLENSNARIFMRLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGH DLKPLLSFLKAKYQVSLENIRIQDTQILAFLKNPEKVGFDEVVREYLKEELIPHETIKDFKTKSRVEKLEQLDMELNALK RLCEYFEKGGLEEGLLALAREVETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKDELHVLERQILDLIGVDFNLNSPKQLS EILYEKLELPQNKSRSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHS PNLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMDAFLKGRDIHLETSKALFGEDLAKEKRS IAKSINFGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDHIK GNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLET SAFMAKRWNELKG
Sequences:
>Translated_893_residues MEEPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAERL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKES AFLSKELATLQRGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNTPLLENAPLLDNAPKKSCM IVLENTAPLSAFLEKLENSNARIFMRLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGH DLKPLLSFLKAKYQVSLENIRIQDTQILAFLKNPEKVGFDEVVREYLKEELIPHETIKDFKTKSRVEKLEQLDMELNALK RLCEYFEKGGLEEGLLALAREVETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKDELHVLERQILDLIGVDFNLNSPKQLS EILYEKLELPQNKSRSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHS PNLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMDAFLKGRDIHLETSKALFGEDLAKEKRS IAKSINFGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDHIK GNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLET SAFMAKRWNELKG >Mature_893_residues MEEPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAERL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKES AFLSKELATLQRGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNTPLLENAPLLDNAPKKSCM IVLENTAPLSAFLEKLENSNARIFMRLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGH DLKPLLSFLKAKYQVSLENIRIQDTQILAFLKNPEKVGFDEVVREYLKEELIPHETIKDFKTKSRVEKLEQLDMELNALK RLCEYFEKGGLEEGLLALAREVETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKDELHVLERQILDLIGVDFNLNSPKQLS EILYEKLELPQNKSRSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHS PNLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMDAFLKGRDIHLETSKALFGEDLAKEKRS IAKSINFGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDHIK GNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLET SAFMAKRWNELKG
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=510, Percent_Identity=29.8039215686275, Blast_Score=201, Evalue=3e-51, Organism=Homo sapiens, GI139394648, Length=538, Percent_Identity=24.7211895910781, Blast_Score=146, Evalue=1e-34, Organism=Escherichia coli, GI1790294, Length=942, Percent_Identity=32.2717622080679, Blast_Score=388, Evalue=1e-108, Organism=Escherichia coli, GI226510970, Length=192, Percent_Identity=37.5, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI86563272, Length=442, Percent_Identity=29.4117647058824, Blast_Score=185, Evalue=9e-47, Organism=Drosophila melanogaster, GI17933644, Length=421, Percent_Identity=30.4038004750594, Blast_Score=179, Evalue=8e-45,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 102426; Mature: 102426
Theoretical pI: Translated: 7.55; Mature: 7.55
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEEPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKN CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC MPFIVFALESQTKTKRAERLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEA CCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCH DDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTEFLAKDCVEKYGILPSQFTDY HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC QGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKES CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH AFLSKELATLQRGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILD HHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEC NTPLLENAPLLDNAPKKSCMIVLENTAPLSAFLEKLENSNARIFMRLVLDKEKKVLALAF CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEE LYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGHDLKPLLSFLKAKYQVSLENI EEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEHHHE RIQDTQILAFLKNPEKVGFDEVVREYLKEELIPHETIKDFKTKSRVEKLEQLDMELNALK EEEHHHEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH RLCEYFEKGGLEEGLLALAREVETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKDELHVLE HHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH RQILDLIGVDFNLNSPKQLSEILYEKLELPQNKSRSTDEKSLLKILDKHPSIALILEYRE HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHH LNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGF HHHHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC IASSKEYCLLGVDYSQIELRLLAHFSQDKDLMDAFLKGRDIHLETSKALFGEDLAKEKRS CCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH IAKSINFGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKA HHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH FTLLGRYRVFDFTGANDHIKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLL HHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEH LQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETSAFMAKRWNELKG HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCC >Mature Secondary Structure MEEPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKN CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC MPFIVFALESQTKTKRAERLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEA CCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCH DDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTEFLAKDCVEKYGILPSQFTDY HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC QGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKES CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH AFLSKELATLQRGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILD HHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEC NTPLLENAPLLDNAPKKSCMIVLENTAPLSAFLEKLENSNARIFMRLVLDKEKKVLALAF CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEE LYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGHDLKPLLSFLKAKYQVSLENI EEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEHHHE RIQDTQILAFLKNPEKVGFDEVVREYLKEELIPHETIKDFKTKSRVEKLEQLDMELNALK EEEHHHEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH RLCEYFEKGGLEEGLLALAREVETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKDELHVLE HHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH RQILDLIGVDFNLNSPKQLSEILYEKLELPQNKSRSTDEKSLLKILDKHPSIALILEYRE HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHH LNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGF HHHHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC IASSKEYCLLGVDYSQIELRLLAHFSQDKDLMDAFLKGRDIHLETSKALFGEDLAKEKRS CCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH IAKSINFGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKA HHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH FTLLGRYRVFDFTGANDHIKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLL HHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEH LQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETSAFMAKRWNELKG HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]