Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 188528052

GI number: 188528052

Start: 1285078

End: 1286307

Strand: Direct

Name: nuoD [H]

Synonym: HPSH_06545

Alternate gene names: 188528052

Gene position: 1285078-1286307 (Clockwise)

Preceding gene: 188528051

Following gene: 188528053

Centisome position: 79.89

GC content: 43.9

Gene sequence:

>1230_bases
ATGGCTCAAAATTTCACGAAACTCAACCCTCAGTTTGAAAACATCATTTTTGAACATGACGACAACCAAATGATTTTAAA
CTTTGGCCCCCAACACCCCAGCAGTCATGGGCAGTTGCGCTTGATTTTGGAATTAGAAGGCGAAAAAATCATTAAGGCTA
CCCCTGAAATTGGCTACTTGCATAGAGGCTGTGAAAAGTTAGGCGAAAACATGACCTATAACGAATACATGCCCACTACC
GACAGATTGGATTACACTTCTTCTACCAGCAATAATTACGCTTACGCACATGCGGTAGAAACCTTGCTCAATTTAGAAAT
CCCTCGTCGAGCGCAAGTGATCCGCACGATTTTACTAGAGCTTAACCGCATGATCTCACACATCTTTTTTATCAGCGTGC
ATGCTTTAGATGTGGGGGCGATGAGCGTGTTTTTGTATGCGTTTAAAACGAGGGAATACGGGCTGGATTTGATGGAGGAT
TATTGCGGGGCTAGGCTCACGCATAACGCTATAAGGATTGGGGGCGTGCCTTTGGATTTACCCCCTAATTGGTTAGAAGG
CTTAAAAAAGTTTTTAGGCGAAATGAGGGAATGCAAAAAACTCATTCAAGGCTTATTGGACAAGAATCGCATTTGGCGGA
TGCGCTTGGAAAATGTGGGCGTTGTAACGCCAAAAATGGCGCAAAGCTGGGGCATGAGCGGTATCATGTTAAGAGGGAGT
GGGATCGCTTATGACATTAGAAAAGAAGAACCTTATGAGCTTTATAAAGAGCTTGATTTTGATGTGCCGGTGGGCAATTA
TGGCGATAGCTATGATAGGTATTGTTTGTATATGCTAGAAATTGATGAAAGCATCCGCATCATTGAACAACTCATTCCCA
TGTATGCTAAAACCGATACGCCTATCATGGCTCAAAACCCGCATTATATTTCTGCCCCTAAAGAAGATATAATGACGCAA
AACTACGCCTTGATGCAGCATTTTGTTTTAGTGGCTCAAGGCATGCGCCCGCCCGTTGGGGAAGTGTATGCCCCCACAGA
AAGCCCTAAAGGGGAATTAGGGTTTTTTATCCATTCAGAAGGCGAGCCTTACCCTCATAGATTAAAAATCAGAGCCCCTA
GCTTTTATCACATTGGGGCTTTAAGCGATATTTTAGTAGGGCAATATTTAGCGGATGCGGTAACCGTGATTGGCTCAACC
AATGCGGTGTTTGGCGAGGTGGATAGATGA

Upstream 100 bases:

>100_bases
GAATTAAAAGAAACAGAAGAAAAGCATGCGTTTAAGAAAATCCCTTTTGTCAAAGATTTGCACAAAATCGCCCCCACTAT
CTTAAAAAAGAGGCTATAAA

Downstream 100 bases:

>100_bases
AACGCTTTGATTTACGCCCCTTAAAAGCGGGTATTTTTGAACGCTTAGAAGAATTGATTGAAAAAGAAATGCAACCTAAT
GAAGTCGCTATTTTCATGTT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSTSNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGS
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPVGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGST
NAVFGEVDR

Sequences:

>Translated_409_residues
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSTSNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGS
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPVGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGST
NAVFGEVDR
>Mature_408_residues
AQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYLHRGCEKLGENMTYNEYMPTTD
RLDYTSSTSNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDY
CGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGSG
IAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQN
YALMQHFVLVAQGMRPPVGEVYAPTESPKGELGFFIHSEGEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTN
AVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=406, Percent_Identity=42.6108374384236, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI260898743, Length=400, Percent_Identity=41.75, Blast_Score=314, Evalue=9e-86,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=36.8286445012788, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1789076, Length=394, Percent_Identity=27.6649746192893, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788832, Length=399, Percent_Identity=27.8195488721804, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=44.0203562340967, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17555284, Length=403, Percent_Identity=42.9280397022332, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=43.3673469387755, Blast_Score=347, Evalue=9e-96,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=42.4870466321244, Blast_Score=320, Evalue=8e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46700; Mature: 46569

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYL
CCCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEECCCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSTSNNYAYAHAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPVGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQNFTKLNPQFENIIFEHDDNQMILNFGPQHPSSHGQLRLILELEGEKIIKATPEIGYL
CCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEECCCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSTSNNYAYAHAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREYGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYKELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPVGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GEPYPHRLKIRAPSFYHIGALSDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA