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The map label for this gene is trpS [H]

Identifier: 188528042

GI number: 188528042

Start: 1278498

End: 1279478

Strand: Reverse

Name: trpS [H]

Synonym: HPSH_06495

Alternate gene names: 188528042

Gene position: 1279478-1278498 (Counterclockwise)

Preceding gene: 188528043

Following gene: 188528041

Centisome position: 79.54

GC content: 39.96

Gene sequence:

>981_bases
ATGCACAAAAAACGAGTCTTTTCAGGCATCCAACCTACCGGGCAAATCCATTTGGGCAACTATTTAGGAGCGATCAAGCA
TTGGGTAGAGGCACAAGATGAATATGAAAACCTTTTTTGCGTCGTCAATTCGCATGCGATTACTTTGCCCATAGATCCTC
TATTTTTAAAATCCCAAAGCTATGAGCTGGTCAAATTGCTTTTAGCTTGCGGAATCAATCCCAAGCAATCGGGGTTATTC
ATTCAAAGTGAAATTGATGAGCACCCGGCTTTAGCATGGCTATTAAATTGTCAGGTGTCTATGGGGGAAATGCAAAGAAT
GACGCAATTCAAAGACAAGTCTTTAAAAAACCCTAAAAGCGTGAATGTGGGGCTTTTCAATTACCCTATTTTAATGGCGT
CAGATATTTTATTATACCAAAGCGATTTAGTGCCAGTGGGCGAAGATCAAAAACAGCATTTAGAGCTCACGCGAAACATT
GCAGAAAAATTTAACAGGGATTTTGGGAGTTGCTTTAAAGTGCCAGAGCCTTTGATCGCTAAAGTGGGGGCAAGGGTTAT
GGGGCTAGATGATCCAAAAGTGAAGATGAGTAAATCGCATCAAGGGGCTAACCATGCGATTTTTCTTTTAGATGAGCCAG
ACATTATTGTAAGAAAAATCAAAAAAGCGACCACTGATTCTGTGGGCGTTATTGCATTTGATGAAAAAAGAGAGGGTGTT
TTTAACCTTTTAAATATCTACATGCTTTTAAGCAATGAAAGCCCAGAAAACATAGAAGAGCGTTTCAAAAATAAGGGCTA
TGGGGATTTTAAAAAGGAATTGGCTGAAGTGGTGATCCAGGCTTTAAAACCCATTCAAGAAAGATACAAAGAAATCAGCG
ACGATGAAGTGAAAGCCGTTTTAAATGGCGGTGTCAAAAAAGCTAGGCCTTTAGCGCAAGCGACTTACCAAAAGGCTAAA
GAATTGATGGGGTTGGTTTAG

Upstream 100 bases:

>100_bases
TACTCTTTTCTGGGATCAAGCGTTCTTAAAAACTAAGATAAATTAAAATATTAAAATTAGGTGGTTACAATAAACGCTAA
ACTAATGAGCGAGAAACAAC

Downstream 100 bases:

>100_bases
ATGAAAATTTTAGGCTTATGGTTAGGGGTGTTTTGTTTCCTTAAGGCTACGCCTTATTTATACTTGGGCGAAGAGCCTAA
ATATAAAGACAATTTCACGC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEAQDEYENLFCVVNSHAITLPIDPLFLKSQSYELVKLLLACGINPKQSGLF
IQSEIDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNI
AEKFNRDFGSCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVRKIKKATTDSVGVIAFDEKREGV
FNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVVIQALKPIQERYKEISDDEVKAVLNGGVKKARPLAQATYQKAK
ELMGLV

Sequences:

>Translated_326_residues
MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEAQDEYENLFCVVNSHAITLPIDPLFLKSQSYELVKLLLACGINPKQSGLF
IQSEIDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNI
AEKFNRDFGSCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVRKIKKATTDSVGVIAFDEKREGV
FNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVVIQALKPIQERYKEISDDEVKAVLNGGVKKARPLAQATYQKAK
ELMGLV
>Mature_326_residues
MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEAQDEYENLFCVVNSHAITLPIDPLFLKSQSYELVKLLLACGINPKQSGLF
IQSEIDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNI
AEKFNRDFGSCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVRKIKKATTDSVGVIAFDEKREGV
FNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVVIQALKPIQERYKEISDDEVKAVLNGGVKKARPLAQATYQKAK
ELMGLV

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=328, Percent_Identity=41.7682926829268, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=51.9553072625698, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI1789786, Length=331, Percent_Identity=47.7341389728097, Blast_Score=320, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=34.4311377245509, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=34.4311377245509, Blast_Score=205, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=347, Percent_Identity=41.7867435158501, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24666151, Length=327, Percent_Identity=39.7553516819572, Blast_Score=247, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 36755; Mature: 36755

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEAQDEYENLFCVVNSHAITLPIDPLFLKSQS
CCCHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCHHHCCCCC
YELVKLLLACGINPKQSGLFIQSEIDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKS
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCC
VNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRDFGSCFKVPEPLIA
CEEEHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHH
KVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVRKIKKATTDSVGVIAFDEKREGV
HHCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHH
FNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVVIQALKPIQERYKEISDDEVKAV
HHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LNGGVKKARPLAQATYQKAKELMGLV
HHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEAQDEYENLFCVVNSHAITLPIDPLFLKSQS
CCCHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCHHHCCCCC
YELVKLLLACGINPKQSGLFIQSEIDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKS
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCC
VNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRDFGSCFKVPEPLIA
CEEEHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHH
KVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVRKIKKATTDSVGVIAFDEKREGV
HHCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHH
FNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVVIQALKPIQERYKEISDDEVKAV
HHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LNGGVKKARPLAQATYQKAKELMGLV
HHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]