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The map label for this gene is rnr [H]

Identifier: 188528038

GI number: 188528038

Start: 1272341

End: 1274275

Strand: Reverse

Name: rnr [H]

Synonym: HPSH_06465

Alternate gene names: 188528038

Gene position: 1274275-1272341 (Counterclockwise)

Preceding gene: 188528039

Following gene: 188528037

Centisome position: 79.22

GC content: 37.98

Gene sequence:

>1935_bases
ATGCAAGGGTTTTTAAGAAGCCTGTTTTTTGGGGTTAAAAAGATCCCTAAACCATTCGCTCCTCTAATAGAAAAGGGCGT
TTTAAAAGAAGCGCTTGGATGCAACAAGGAACGCTATTTTTTAAAAGAAGGCTTTGATATAGGCAGAATTGAGTGGGCAG
AAAATAAGGCGTTTTTCATTTCTTTAGCGAAAAATTACCCCAAAGACCCTTTAATCAAAAACTTACCCCCATCTTTTAAA
ACAGACGCTTTGATTTTATGCAAAATAGAATGTTCTAAAAAACGCCCCATAGCCTTTTTTAAAGCCGCGCTTTTAAATGC
AGATCACACGATAATAGCTTACCTGGCTAAAAAAAATCACCAGATTGTGGCTATCCCTTTTAAAGAGCCTTTTAAAAAAC
CCATTCTTTTAAAGCACAGCCAAAGATCCTTATTAGAATTGCCCAGGCATTGCGTGGTAAAGATCGATCTTAAAAAGCGT
GAAATCAGCGAAATTTTAGGGGCTTTAGAAGACCCTTTAATAGATGAAAACCTTTCTTTAAGCCTTTTTGACAGGATTAA
GGATTTTTCAAAAGATTGTTTGGATTTAGCCCAACATTATGCGCAACTTAAAGCGAGCGATTTTAAAAATAGGATCAATT
ATTCTCACCTCCCTTTTATCACCATTGATCCTAAAGACGCTAAGGATTTTGACGATGCGATTTTTTATGATCAAGAAAAA
AGGGTTTTGTTTGTGGCGGTTGCTGATGTGAGCGAATTTGTGCCGAAATATTCCAGTTTGGATAAAGAAGCTAGGGTTAG
GGGCTTTAGCGTGTATTTCCCTAATAGCGTGTATCCCATGCTGCCTTTGAGTTTGTCTCAAGGGGCATGCTCACTAAAAG
CGTTTGAAAAACGCCTGGCTTTAGTGTATGAAATCCCTTTAGATGATTTGGAAAACGCCCGATTGTTTCAAGGAGTTATT
GAAGTTAGGGCTAATTGCACCTATGAAGAAATCAACCATTTTTTAACCACCCAACAAAGCTCGTTAGATAACGACTTGCA
ACAAAGCCTTTTGGGGTTTTTAGAAATGGCTTTAAAGTTAAAAAAGGAGCGTTTAAAAAAGGGGTTTAATTTCAATTCGT
TTGAAAACAAGCTGTATTTGAATAAAGAAGGGCGTATAGAAAAAATTGAAACGCAAACAGAAAGCAACGCGCACACCCTT
ATAGAAGGAGCCATGTTATTAGCCAACCAATCTAGCGCGAATTTATTGGATAAGCATTTTCAAAATAAGGGGATATACCG
CACCCATAAAGAGCCAAGTTTGGAGCAGCAAAAACGCCTCTACGACAAGCTTTTTGATTATGAGATCATGCGCCCTAAAA
ACATGGGCTTTTTCCCTTTTTTAGAGCATGCCTTAAAGATAGCCAAAGAAAAGAAGTTAGAAAGAGAAGTTTCGCGCTTG
ATCATTAAATCTCAAAATTTAGCCCTTTATAGCCCCATGCAAGAAAGCCATTTTGGTTTGGGGTTTGCCAGCTATACGCA
TTTCACTTCGCCCATTAGACGATACAGCGATTTAGCCTTACACAGGCTTTTAAAAGAATTGTTGTTTCATCAAGCTAAAG
GCTGCTCGTATTTGTTAGAAGAAACGCCTGAATTATGCGCTGAGTTGAACGCTTTACAAAAAAAGACCGCTTTGATTGAA
AGGGATTTTGTCAAACGCAAATTCGCCCGCTTAGCTTTAGAACTTTTAGAAAAAGAATTTTTGGGCGTTGTTTTGGAGGT
TAAAGATTGGGTGGTGGTGGGGCTAAAAGAATTAATAGGGCTTAAAGTTTTAGTCAAAACGAATAAGGTTTTTAAGTCTT
TAGAAAAGGTGCGCGTTAAAATCACGCATGCGGATTTGGTTTTAGGGCAAGTTTGGGGTGAAATCACAGAAAGGATTAAA
GAGCATGTATCGTAA

Upstream 100 bases:

>100_bases
AAGACATGCTCATCTATCAAGCCTCTTTAAGTTTTGAAAAATTCAGCGCTTCTCAAATCCCTTATTCAAAAGCGTTTGAA
GTCATGCGAAGTGTTTTTTG

Downstream 100 bases:

>100_bases
AGATTTGGACAATTATTTAAAACAACGACTCCCTAAAGCGGTGTTTTTGTATGGGGAGTTTGATTTTTTTATCCATTATT
ATATTCAAACGATTAGCTCG

Product: 3'-5' exoribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALGCNKERYFLKEGFDIGRIEWAENKAFFISLAKNYPKDPLIKNLPPSFK
TDALILCKIECSKKRPIAFFKAALLNADHTIIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGALEDPLIDENLSLSLFDRIKDFSKDCLDLAQHYAQLKASDFKNRINYSHLPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKYSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDDLENARLFQGVI
EVRANCTYEEINHFLTTQQSSLDNDLQQSLLGFLEMALKLKKERLKKGFNFNSFENKLYLNKEGRIEKIETQTESNAHTL
IEGAMLLANQSSANLLDKHFQNKGIYRTHKEPSLEQQKRLYDKLFDYEIMRPKNMGFFPFLEHALKIAKEKKLEREVSRL
IIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKTALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKELIGLKVLVKTNKVFKSLEKVRVKITHADLVLGQVWGEITERIK
EHVS

Sequences:

>Translated_644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALGCNKERYFLKEGFDIGRIEWAENKAFFISLAKNYPKDPLIKNLPPSFK
TDALILCKIECSKKRPIAFFKAALLNADHTIIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGALEDPLIDENLSLSLFDRIKDFSKDCLDLAQHYAQLKASDFKNRINYSHLPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKYSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDDLENARLFQGVI
EVRANCTYEEINHFLTTQQSSLDNDLQQSLLGFLEMALKLKKERLKKGFNFNSFENKLYLNKEGRIEKIETQTESNAHTL
IEGAMLLANQSSANLLDKHFQNKGIYRTHKEPSLEQQKRLYDKLFDYEIMRPKNMGFFPFLEHALKIAKEKKLEREVSRL
IIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKTALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKELIGLKVLVKTNKVFKSLEKVRVKITHADLVLGQVWGEITERIK
EHVS
>Mature_644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALGCNKERYFLKEGFDIGRIEWAENKAFFISLAKNYPKDPLIKNLPPSFK
TDALILCKIECSKKRPIAFFKAALLNADHTIIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGALEDPLIDENLSLSLFDRIKDFSKDCLDLAQHYAQLKASDFKNRINYSHLPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKYSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDDLENARLFQGVI
EVRANCTYEEINHFLTTQQSSLDNDLQQSLLGFLEMALKLKKERLKKGFNFNSFENKLYLNKEGRIEKIETQTESNAHTL
IEGAMLLANQSSANLLDKHFQNKGIYRTHKEPSLEQQKRLYDKLFDYEIMRPKNMGFFPFLEHALKIAKEKKLEREVSRL
IIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKTALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKELIGLKVLVKTNKVFKSLEKVRVKITHADLVLGQVWGEITERIK
EHVS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=401, Percent_Identity=29.925187032419, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI190014623, Length=401, Percent_Identity=29.925187032419, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI134288890, Length=390, Percent_Identity=27.4358974358974, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI219521928, Length=373, Percent_Identity=27.0777479892761, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19115966, Length=373, Percent_Identity=27.0777479892761, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI87082383, Length=403, Percent_Identity=34.4913151364764, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787542, Length=382, Percent_Identity=27.7486910994764, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI212645896, Length=461, Percent_Identity=27.9826464208243, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=26.6503667481663, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324552, Length=334, Percent_Identity=29.940119760479, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323943, Length=439, Percent_Identity=24.1457858769932, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649634, Length=374, Percent_Identity=28.0748663101604, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24654592, Length=423, Percent_Identity=26.7139479905437, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922976, Length=425, Percent_Identity=26.5882352941176, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24654597, Length=425, Percent_Identity=26.5882352941176, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 74326; Mature: 74326

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALGCNKERYFLKEGFDIGRIEWAENKAFFI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCCEEEE
SLAKNYPKDPLIKNLPPSFKTDALILCKIECSKKRPIAFFKAALLNADHTIIAYLAKKNH
EECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCC
QIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKREISEILGALEDPLIDENLSL
EEEEEECCCCCCCCCEEECCHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCH
SLFDRIKDFSKDCLDLAQHYAQLKASDFKNRINYSHLPFITIDPKDAKDFDDAIFYDQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEECCCC
RVLFVAVADVSEFVPKYSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLA
CEEEEEEHHHHHHHHHHHCCCHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVYEIPLDDLENARLFQGVIEVRANCTYEEINHFLTTQQSSLDNDLQQSLLGFLEMALKL
EEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KKERLKKGFNFNSFENKLYLNKEGRIEKIETQTESNAHTLIEGAMLLANQSSANLLDKHF
HHHHHHCCCCCCCCCCEEEECCCCCEEEEHHCCCCCHHHHHHHHHHEECCCCHHHHHHHH
QNKGIYRTHKEPSLEQQKRLYDKLFDYEIMRPKNMGFFPFLEHALKIAKEKKLEREVSRL
HCCCCEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLE
HHHCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ETPELCAELNALQKKTALIERDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKELIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKVLVKTNKVFKSLEKVRVKITHADLVLGQVWGEITERIKEHVS
EEHEEEHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALGCNKERYFLKEGFDIGRIEWAENKAFFI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCCEEEE
SLAKNYPKDPLIKNLPPSFKTDALILCKIECSKKRPIAFFKAALLNADHTIIAYLAKKNH
EECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCC
QIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKREISEILGALEDPLIDENLSL
EEEEEECCCCCCCCCEEECCHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCH
SLFDRIKDFSKDCLDLAQHYAQLKASDFKNRINYSHLPFITIDPKDAKDFDDAIFYDQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEECCCC
RVLFVAVADVSEFVPKYSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLA
CEEEEEEHHHHHHHHHHHCCCHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVYEIPLDDLENARLFQGVIEVRANCTYEEINHFLTTQQSSLDNDLQQSLLGFLEMALKL
EEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KKERLKKGFNFNSFENKLYLNKEGRIEKIETQTESNAHTLIEGAMLLANQSSANLLDKHF
HHHHHHCCCCCCCCCCEEEECCCCCEEEEHHCCCCCHHHHHHHHHHEECCCCHHHHHHHH
QNKGIYRTHKEPSLEQQKRLYDKLFDYEIMRPKNMGFFPFLEHALKIAKEKKLEREVSRL
HCCCCEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIKSQNLALYSPMQESHFGLGFASYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLE
HHHCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ETPELCAELNALQKKTALIERDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKELIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKVLVKTNKVFKSLEKVRVKITHADLVLGQVWGEITERIKEHVS
EEHEEEHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]