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The map label for this gene is hemN [H]

Identifier: 188528013

GI number: 188528013

Start: 1251364

End: 1252401

Strand: Reverse

Name: hemN [H]

Synonym: HPSH_06340

Alternate gene names: 188528013

Gene position: 1252401-1251364 (Counterclockwise)

Preceding gene: 188528020

Following gene: 188528009

Centisome position: 77.86

GC content: 38.92

Gene sequence:

>1038_bases
ATGATTTTATACATTCATATCCCCTTTTGTGAAAATAAATGCGGTTATTGCGCTTTCAATTCCTATGAAAATAAGCATGG
GCTAAAAGAAGAATACACTCAAGCGTTATGCCTGGATTTAAAGCATGCCTTAAGCCAAACTGATGAACCAATTGAGAGCG
TTTTTATTGGCGGCGGCACGCCTAACACTTTAAGCGTGGAGTCTTTTGAAAGGATTTTTGAAAGCATTTATCGCAATGCG
TGCTTGAGCATGGATTGCGAGATCACCACTGAAGCTAACCCCGAATTGATCACTAAAGCTTGGTGTCAAGGCTTAAAAGA
TTTAGGGATCAACCGCTTGAGTTTAGGGGTGCAAAGTTTTAGGGAGGATAAATTATTGTTTTTAGAGCGCCAACATTCCA
AAAATATCGCTCCTGTGATAGAAACTATTTTAAAAAGCGGGATTGAAAATGTCAGCATTGATTTGATTTATAACACCCCA
TTGGACAATGAAAACTCTCTAAAAGAAGAATTAAAACTCGCTAAAGAACTCCCTATCAACCACTTGAGCGCTTATGCTTT
GAGCGTTGAAAAAAACACGAATTTAGAAAAAAACGCCAAAAAACCCTCATGCACCAATTTTGACAATATAATAAAAGAGG
TTTTAGAGGGCTTTTCTTTCAAGCAATACGAAGTGTCTAATTACGCTAGAAATTATCAAGTCAAGCACAATTTGGCTTAC
TGGGGGGCTAAAGATTATTTAGGGTGTGGGGCTGGGGCTGTAGGCTGCGTGGCGAATGAGCGCTTTTATGCGAAAAAACT
CATAGAAAACTACATCAAAGACCCCCTAAAACGCCAAATTGAGACGCTTAGCGAACAAGACAAGCGCTTAGAAAAGCTGT
TTTTAGGCTTGAGGTGTGTGCTGGGGGTTGAGCTTAGTTTCTTAGATGAAAATAAAGTAAAGTTTTTGATTGAAGAAAAT
AAGGCTTTCATTAAAAATGACCGATTGGTAGCGAGCGATTTTTTCATGGCCGATGAAATGGCTTTGTGGCTGTTGTAA

Upstream 100 bases:

>100_bases
TTCATAGTGTGTCTCCTCATGCTTATCAAAATAATCTTAAAATGATACAATTACAAGTTTAAGTTTCGCTTAAAATGAAA
TGAAAATAAGAGAAATAAAT

Downstream 100 bases:

>100_bases
GGCTCTGCTTTAATCAAGCGTTAATAAAACGCTAAAAAGCGTTTTTTAATTAATGCCTACAAAATTTTTAGCCAAAAACC
AACCAATGGCTACCCCAATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVESFERIFESIYRNA
CLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIAPVIETILKSGIENVSIDLIYNTP
LDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCTNFDNIIKEVLEGFSFKQYEVSNYARNYQVKHNLAY
WGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQIETLSEQDKRLEKLFLGLRCVLGVELSFLDENKVKFLIEEN
KAFIKNDRLVASDFFMADEMALWLL

Sequences:

>Translated_345_residues
MILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVESFERIFESIYRNA
CLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIAPVIETILKSGIENVSIDLIYNTP
LDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCTNFDNIIKEVLEGFSFKQYEVSNYARNYQVKHNLAY
WGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQIETLSEQDKRLEKLFLGLRCVLGVELSFLDENKVKFLIEEN
KAFIKNDRLVASDFFMADEMALWLL
>Mature_345_residues
MILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVESFERIFESIYRNA
CLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIAPVIETILKSGIENVSIDLIYNTP
LDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCTNFDNIIKEVLEGFSFKQYEVSNYARNYQVKHNLAY
WGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQIETLSEQDKRLEKLFLGLRCVLGVELSFLDENKVKFLIEEN
KAFIKNDRLVASDFFMADEMALWLL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=33.7078651685393, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1789325, Length=270, Percent_Identity=37.037037037037, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082341, Length=283, Percent_Identity=26.8551236749117, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 39406; Mature: 39406

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGT
CEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCC
PNTLSVESFERIFESIYRNACLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSF
CCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
REDKLLFLERQHSKNIAPVIETILKSGIENVSIDLIYNTPLDNENSLKEELKLAKELPIN
CCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHH
HLSAYALSVEKNTNLEKNAKKPSCTNFDNIIKEVLEGFSFKQYEVSNYARNYQVKHNLAY
HHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHCCEEEECEEE
WGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQIETLSEQDKRLEKLFLGLRCV
CCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVELSFLDENKVKFLIEENKAFIKNDRLVASDFFMADEMALWLL
HCCEEEEECCCCEEEEEECCCHHHHCCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGT
CEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCC
PNTLSVESFERIFESIYRNACLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSF
CCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
REDKLLFLERQHSKNIAPVIETILKSGIENVSIDLIYNTPLDNENSLKEELKLAKELPIN
CCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHH
HLSAYALSVEKNTNLEKNAKKPSCTNFDNIIKEVLEGFSFKQYEVSNYARNYQVKHNLAY
HHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHCCEEEECEEE
WGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQIETLSEQDKRLEKLFLGLRCV
CCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVELSFLDENKVKFLIEENKAFIKNDRLVASDFFMADEMALWLL
HCCEEEEECCCCEEEEEECCCHHHHCCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]