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The map label for this gene is hemD

Identifier: 188528011

GI number: 188528011

Start: 1250199

End: 1250879

Strand: Direct

Name: hemD

Synonym: HPSH_06330

Alternate gene names: NA

Gene position: 1250199-1250879 (Clockwise)

Preceding gene: 188528010

Following gene: 188528012

Centisome position: 77.72

GC content: 38.18

Gene sequence:

>681_bases
ATGAGAGAGATTGTATGGGTGCATTCTCAAAGAATCGCCCCTTATAAGACTCTCATTTTAAATGAATTTTGCTACTATCC
CTTAGAATTAGATCCAACCCCTTTTAACGCCCTTATTTTCACCTCTAAAAATGCGGTGTTTTCCTTGCTAGAAACTCTAA
AAAACAGCCCCAAACTCAAAATTTTACAAAACATTCCTGCTTACGCTTTGAGCGAACCCACCGCAAAAACCTTACAAGAT
CACCATTTTAAAGTCGCCTTTATAGGGGAAAAAGCCCATGGCAAAGAGTTCGTTCAAGAAATCCTTCCTTTATTGGAAAA
AAAAAGCGTTTTGTATCTCAGGGCAAAAGAAATTGCTTCTTCTTTAGACACCATTCTTTTAGAGCATGGCATTGATTTCA
AGCAAGCCGTTGTTTATGAAAACAAGCTCAAACATTTAACCTTAAGCGAACAAAACGCCCTAAAACCCAAAGAAAAGAGC
ATTCTTATTTTTACCGCCATAAGCCATGCAAAAGCCTTCTTGCACTATTTTGAATTTTTAGAAAATTACACCGCTATAAG
CATTGGCAACACGACCGCTCTTTATTTGCAAGAGCAAGGCATTCAAAGCTATAGCGCCAAAAAGCCCTCCTTAGAAGCGT
GTTTAGAACTGGCTTTGAGTTTGAGGGTTAAGGAATGTTAA

Upstream 100 bases:

>100_bases
TAGGCTATACGCCCTATTATTTAGAGGGCGATGTCTATGATTTTGAAAAATACGGCTTTAGAATGGTCTATGATGACGCT
TGCGGTAAAAAAAACTAGGC

Downstream 100 bases:

>100_bases
AAACATCTCATTATAATGCTCTCAGTGATTTTTTAAAGGGTGATGCATGAATTTTATTTTTTTATGGGCCGCTTTAGGGG
GGGCTATAGGGAGTTCGTTA

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase HemD; Uroporphyrinogen III Cosynthase HemD; Uroporphyrinogen-III Synthetase; Uroporphyrinogen III Cosynthase

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MREIVWVHSQRIAPYKTLILNEFCYYPLELDPTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQD
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
ILIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIQSYSAKKPSLEACLELALSLRVKEC

Sequences:

>Translated_226_residues
MREIVWVHSQRIAPYKTLILNEFCYYPLELDPTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQD
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
ILIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIQSYSAKKPSLEACLELALSLRVKEC
>Mature_226_residues
MREIVWVHSQRIAPYKTLILNEFCYYPLELDPTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQD
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
ILIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIQSYSAKKPSLEACLELALSLRVKEC

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25755; Mature: 25755

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIVWVHSQRIAPYKTLILNEFCYYPLELDPTPFNALIFTSKNAVFSLLETLKNSPKLK
CCCEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCEEEEECCHHHHHHHHHHHCCCCEE
ILQNIPAYALSEPTAKTLQDHHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIAS
EECCCCCHHCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHH
SLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKSILIFTAISHAKAFLHYFEFL
HHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ENYTAISIGNTTALYLQEQGIQSYSAKKPSLEACLELALSLRVKEC
HCCEEEEECCEEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MREIVWVHSQRIAPYKTLILNEFCYYPLELDPTPFNALIFTSKNAVFSLLETLKNSPKLK
CCCEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCEEEEECCHHHHHHHHHHHCCCCEE
ILQNIPAYALSEPTAKTLQDHHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIAS
EECCCCCHHCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHH
SLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKSILIFTAISHAKAFLHYFEFL
HHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ENYTAISIGNTTALYLQEQGIQSYSAKKPSLEACLELALSLRVKEC
HCCEEEEECCEEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA