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The map label for this gene is proC [H]

Identifier: 188527942

GI number: 188527942

Start: 1177233

End: 1177988

Strand: Direct

Name: proC [H]

Synonym: HPSH_05975

Alternate gene names: 188527942

Gene position: 1177233-1177988 (Clockwise)

Preceding gene: 188527941

Following gene: 188527943

Centisome position: 73.19

GC content: 42.72

Gene sequence:

>756_bases
ATGGAAATCTTACAATTCATCGGCTATGGGAATATGGCTCAAGCGATTTTAGAAGGCTCTCATGAAATTTTATCCAAGCA
CTTTATTTTAGAGATTACCGGGCGAAACCCTGAAAAAATCGCCCCTTTTTTACAAGAAAAAAACATTCAAGCGCGCATCA
TTCCCTATAAAGACGCTATTGATATACACCAAAAATTCGTGTTTTTACTTTTTAAGCCTTATAACCTTAAGGATTTTAAT
TATCAAGGGCAAGCCAAAAGCGTTTTGAGCGCACTAGCTGGCGTGGGTTTTGAAGCTTTAAATAATGCGATAAATTCTTT
ACATTACCTCAAATGCATGCCCAATATTGCGAGCAAGTTCGCCCTTTCTTCTACGGCGGTGTGCGAAAAATCGCCCATGC
CCTTAATAAGCCAAAAGGCTTTGAGCGTTATTGAGAGTTTTGGGAATTGCGTGCGAGTGGGCCATGAAGAGTTGGTGGAT
GCCAGCGTGGCGACAAACGGGAGCGCGCTTGCGTTTTTAAGCTTGGTAGCGAACAGTTTGAAAGATGCCGGCATCAGGGA
GGGCTTGAACGCTAGAGATTCTTTAGAATTGGTGAAAATGAGTTTTAAAGGCTTTGCCAAGCTTTTAGAAAAAGAACGCC
CCGAGATGATCATAGAGCAAATTTGCACCCCTAAAGGCGCAACGATTGAAGGCTTGAGCGTTTTAGAAAAAAGGGGGTTA
GGGGAGCGTTTATCAAAGCATGCCAAAAGAGCGTGA

Upstream 100 bases:

>100_bases
AATCAAGCGTATTTAAAAAGTGCCGGGGCTGATGTGAGCTATAGGAGGCTTTATACTTTCTATATCAATTACATCATGGG
GTTTTAAAAAAGGGTGTGTC

Downstream 100 bases:

>100_bases
AAAAAATGCACCCTAAAAATTACACTCTTAAAAAATAAGCGCGATGCATTTAGACAGGCAGAGTTTAGAAAAAGCCAAGC
ATTTGATCCAAAGCGGTCTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MEILQFIGYGNMAQAILEGSHEILSKHFILEITGRNPEKIAPFLQEKNIQARIIPYKDAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFEALNNAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVD
ASVATNGSALAFLSLVANSLKDAGIREGLNARDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKRGL
GERLSKHAKRA

Sequences:

>Translated_251_residues
MEILQFIGYGNMAQAILEGSHEILSKHFILEITGRNPEKIAPFLQEKNIQARIIPYKDAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFEALNNAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVD
ASVATNGSALAFLSLVANSLKDAGIREGLNARDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKRGL
GERLSKHAKRA
>Mature_251_residues
MEILQFIGYGNMAQAILEGSHEILSKHFILEITGRNPEKIAPFLQEKNIQARIIPYKDAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFEALNNAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVD
ASVATNGSALAFLSLVANSLKDAGIREGLNARDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKRGL
GERLSKHAKRA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=255, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI24797097, Length=255, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI24797095, Length=255, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786585, Length=254, Percent_Identity=25.5905511811024, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540664, Length=268, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320861, Length=163, Percent_Identity=29.4478527607362, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648116, Length=260, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27606; Mature: 27606

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILQFIGYGNMAQAILEGSHEILSKHFILEITGRNPEKIAPFLQEKNIQARIIPYKDAI
CCHHHHHCCCHHHHHHHHCHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHH
DIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVGFEALNNAINSLHYLKCMPNIASKF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVDASVATNGSALAFLSLVANSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KDAGIREGLNARDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKRGL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCH
GERLSKHAKRA
HHHHHHHHCCC
>Mature Secondary Structure
MEILQFIGYGNMAQAILEGSHEILSKHFILEITGRNPEKIAPFLQEKNIQARIIPYKDAI
CCHHHHHCCCHHHHHHHHCHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHH
DIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVGFEALNNAINSLHYLKCMPNIASKF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVDASVATNGSALAFLSLVANSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KDAGIREGLNARDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKRGL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCH
GERLSKHAKRA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]