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The map label for this gene is fmt

Identifier: 188527924

GI number: 188527924

Start: 1154441

End: 1155337

Strand: Reverse

Name: fmt

Synonym: HPSH_05875

Alternate gene names: 188527924

Gene position: 1155337-1154441 (Counterclockwise)

Preceding gene: 188527925

Following gene: 188527923

Centisome position: 71.82

GC content: 40.8

Gene sequence:

>897_bases
ATGGGAACGCCGGGGTTTGCTGAAGTGATCTTAAGGGCATTGGTTAAAGATAAAGAGATCGAGGTGGTGGGGCTATTCAC
GCAGATGGATAAACCTTTTGGGCGTAAAAAGGAATTGAAAGCCCCAGAGACTAAAACATACATTCTAGAAAATCATTTAA
ATATCCCCATTTTCCAGCCACAAAGTTTGAAAGAGTCTGAAGTTCAAATCTTAAAAAATCTAAAACCGGATTTTATCGTG
GTGGTGGCTTATGGTAAGATTTTGCCTAAAGAGGTTTTATCAATCGCTCCTTGCATCAATGTGCATGCGTCGTTATTGCC
TAAATACAGGGGGGCTTCGCCCATTCATGAGATGATACTCAATGACGATAAGATTTATGGTATAAGCACCATGCTTATGG
ATGTGGGGCTAGATAGCGGGGATATTTTAGAGAGCGCTTCGTTTTTGAGAGAAGAATACTTGGATTTAGACGCTTTAAAT
TTAAAGTTAGCGCATATGGGGGCAGCCTTACTCCTTTCAACGCTCAAAAATTTCTCTTCCATCACAAGAAAACCCCAAGA
TCACGCACAGGCTAGTTTTTGTAAAAAGATCACCAAAGCCGATGGTTTAGTGGGTTTTAAAGACGCTAAAAGCTTGTTTT
TAAAATCGCTTGCGTTTAAGAGTTGGCCAGAAATCTTTTTAGAAAATAGCCTTAAACTTTTAGGAGTGGAATTGGTGGAG
AATGAAAAGAGCCACAAGGAAGGCGAGATTTTAGAAATTGATGAAAAAGGCGTTCTTGTGGGCTGTTTGAAGGGGAGCGT
GCGTATAGCAAGGTTGCAAGCGGTGGGTAAAAAGCCTTTGAAAGCGAAGGATTATTTGAATGGCAAGCGTTTGAAAGCGG
GCGGTATTTTAACATGA

Upstream 100 bases:

>100_bases
AAAATAGCTATTAATGCTATGAAAATTTTAAATCCTTATCAAACACAATCTTATATGGGGAGTGTGGATAAAAACAAGGA
ATAACATGCGCATCGTATTT

Downstream 100 bases:

>100_bases
GAAAATGTGAAAAAAGAGTTTTTGATAGCCTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTCAAAAACGATGGACTC
AAAGCCCCTATTTTGATCGT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGTPGFAEVILRALVKDKEIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKESEVQILKNLKPDFIV
VVAYGKILPKEVLSIAPCINVHASLLPKYRGASPIHEMILNDDKIYGISTMLMDVGLDSGDILESASFLREEYLDLDALN
LKLAHMGAALLLSTLKNFSSITRKPQDHAQASFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKLLGVELVE
NEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKAGGILT

Sequences:

>Translated_298_residues
MGTPGFAEVILRALVKDKEIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKESEVQILKNLKPDFIV
VVAYGKILPKEVLSIAPCINVHASLLPKYRGASPIHEMILNDDKIYGISTMLMDVGLDSGDILESASFLREEYLDLDALN
LKLAHMGAALLLSTLKNFSSITRKPQDHAQASFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKLLGVELVE
NEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKAGGILT
>Mature_297_residues
GTPGFAEVILRALVKDKEIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKESEVQILKNLKPDFIVV
VAYGKILPKEVLSIAPCINVHASLLPKYRGASPIHEMILNDDKIYGISTMLMDVGLDSGDILESASFLREEYLDLDALNL
KLAHMGAALLLSTLKNFSSITRKPQDHAQASFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKLLGVELVEN
EKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKAGGILT

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=320, Percent_Identity=25.3125, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=37.248322147651, Blast_Score=177, Evalue=8e-46,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=31.5555555555556, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550868, Length=225, Percent_Identity=31.5555555555556, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 32980; Mature: 32849

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPGFAEVILRALVKDKEIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQP
CCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEECC
QSLKESEVQILKNLKPDFIVVVAYGKILPKEVLSIAPCINVHASLLPKYRGASPIHEMIL
CCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHC
NDDKIYGISTMLMDVGLDSGDILESASFLREEYLDLDALNLKLAHMGAALLLSTLKNFSS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITRKPQDHAQASFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKLLGVELVE
HHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
NEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKAGGILT
CCCCCCCCCEEEECCCCEEEEEECCCEEEEHHHHHCCCCCCHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
GTPGFAEVILRALVKDKEIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQP
CCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEECC
QSLKESEVQILKNLKPDFIVVVAYGKILPKEVLSIAPCINVHASLLPKYRGASPIHEMIL
CCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHC
NDDKIYGISTMLMDVGLDSGDILESASFLREEYLDLDALNLKLAHMGAALLLSTLKNFSS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITRKPQDHAQASFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKLLGVELVE
HHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
NEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKAGGILT
CCCCCCCCCEEEECCCCEEEEEECCCEEEEHHHHHCCCCCCHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA