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The map label for this gene is zwf [H]

Identifier: 188527880

GI number: 188527880

Start: 1115304

End: 1116581

Strand: Direct

Name: zwf [H]

Synonym: HPSH_05655

Alternate gene names: 188527880

Gene position: 1115304-1116581 (Clockwise)

Preceding gene: 188527876

Following gene: 188527881

Centisome position: 69.34

GC content: 37.48

Gene sequence:

>1278_bases
ATGTTAGATTTTGATTTGGTTCTTTTTGGCGCGACTGGGGATTTAGCCATGCGAAAGCTCTTTGTTTCGCTCTATGAAAT
TTATACCCATTATGGTTTTAAAAAAGATTCTAAGATTATCGCATCTGGGCGTAAGGAGCTATCCAATGAAGAATTTTTAG
CGCTCCTTTGCGAAAAGACGCAACTGCATTCAAGAGAAAAGGGTGAGGAATTTTTAGCCCATATCAGTTATTTTTGCGTT
CGTTTGGATAACCCTAAAGACTTTGAAGGATTGAGTAAAATCGCTACAAAAAATAAACCCTTGATTTTCTACTTTTCTAT
CTCCCCTAGTTTTTTTGCAACGACCGCTCAACATCTCGCCAAAAACGCGCTCAATCACGCCAATGCGCGCTTGATTTTAG
AAAAGCCTTTAGGGCATGATTTAAAGACTTGTAAGGAGATTTTCCAAAGCATTAGCGCTTTTTTTAAAGAAGAACAGATC
TTTAGAATCGATCATTATTTAGGGAAAAAGGGCGTTCAAAATATCCTTGAATTGCGCTTAAATAACCCTATCTTAAACAT
TTTATGGGATCAAATCAGTGCGGTTGAAATCTGCGTGTATGAGACTTTAGGGGTGGAAGAAAGAGGCGAATTTTACGATA
AAATCGGGGCTTTAAGGGATATGGTTCAAAACCATCTCTTGCAAGTTTTATCCCTTATCGCTACAGATTTACCCAACGAT
TTAAAGGATTTGAGGAAAGAAAAAATCAAAGTTTTAAAAACCTTACAACCCCCTAAAGACTTTAAAAAACAAGTGATCCG
TGCCCAATATCAAGGCTATAGAGATGAAAATAAGGTCCATAAAGAGAGCCAGACAGAAACTTTTATCGCTATTAAAGCCT
TTTTGGATACACCTAAATTTAAAGGCGTGCCTTTCTACCTTAAACACGCTAAAAAAATGCCCCACAACCAAGCGAGCGTG
AAAATCCATTTTAATGCAATCAATACGCTAGAATTTTTCCTCTCTCAAGATAAAATCACCCTCACCCTACAAGATCATCA
AAACCCCCTTATTTTAGAAACCCATCACAAACAAGAATTTTTGCAGCCCTACGCTAAATTGCTCTATGATGCGATACAAA
ATAACCACAACAATTTCGCCCACCAGTTGGAATTGGAAGCGTCATGGGTTTTTATTGACACGCTCATAGAAGGTTTTATG
AATAACGCCACGCCCTTATATTCCTATGAAAGCCACAATCTAAACGAATCCGAATTTTTAAAACCACTCTATCAATGA

Upstream 100 bases:

>100_bases
TTTTCTTTGATTTGTTCTAAAGAATGCTTAGGCATGAACACCCCTTTAATTAAGATTTAATATATAATAATAACTCAAAA
ACACTCTAAAAGGGTTATTG

Downstream 100 bases:

>100_bases
AAGGGATTTCATGGGTTATCAATTGTTTGAATTTGAAAATTTAGAAAATTGCCACAAGGCTTTAACAGAGCGTTTTAAAG
AATTTTTTAACGCCACCTTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLALLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEGLSKIATKNKPLIFYFSISPSFFATTAQHLAKNALNHANARLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFIAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAINTLEFFLSQDKITLTLQDHQNPLILETHHKQEFLQPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLYSYESHNLNESEFLKPLYQ

Sequences:

>Translated_425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLALLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEGLSKIATKNKPLIFYFSISPSFFATTAQHLAKNALNHANARLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFIAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAINTLEFFLSQDKITLTLQDHQNPLILETHHKQEFLQPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLYSYESHNLNESEFLKPLYQ
>Mature_425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLALLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEGLSKIATKNKPLIFYFSISPSFFATTAQHLAKNALNHANARLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFIAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAINTLEFFLSQDKITLTLQDHQNPLILETHHKQEFLQPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLYSYESHNLNESEFLKPLYQ

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=470, Percent_Identity=27.0212765957447, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI109389365, Length=470, Percent_Identity=27.0212765957447, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI52145310, Length=353, Percent_Identity=30.028328611898, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788158, Length=456, Percent_Identity=34.2105263157895, Blast_Score=251, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17538218, Length=445, Percent_Identity=28.7640449438202, Blast_Score=196, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324088, Length=461, Percent_Identity=30.8026030368764, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24643350, Length=465, Percent_Identity=29.0322580645161, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643352, Length=465, Percent_Identity=29.0322580645161, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221513548, Length=361, Percent_Identity=26.3157894736842, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 49375; Mature: 49375

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLALLCEKT
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
QLHSREKGEEFLAHISYFCVRLDNPKDFEGLSKIATKNKPLIFYFSISPSFFATTAQHLA
HHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
KNALNHANARLILEKPLGHDLKTCKEIFQSISAFFKEEQIFRIDHYLGKKGVQNILELRL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
NNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFIAIKAFLDTPKF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
KGVPFYLKHAKKMPHNQASVKIHFNAINTLEFFLSQDKITLTLQDHQNPLILETHHKQEF
CCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHH
LQPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFMNNATPLYSYESHNLNESEFL
HHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
KPLYQ
HHHCC
>Mature Secondary Structure
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLALLCEKT
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
QLHSREKGEEFLAHISYFCVRLDNPKDFEGLSKIATKNKPLIFYFSISPSFFATTAQHLA
HHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
KNALNHANARLILEKPLGHDLKTCKEIFQSISAFFKEEQIFRIDHYLGKKGVQNILELRL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
NNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVHKESQTETFIAIKAFLDTPKF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
KGVPFYLKHAKKMPHNQASVKIHFNAINTLEFFLSQDKITLTLQDHQNPLILETHHKQEF
CCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHH
LQPYAKLLYDAIQNNHNNFAHQLELEASWVFIDTLIEGFMNNATPLYSYESHNLNESEFL
HHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
KPLYQ
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]