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The map label for this gene is gdhA [H]

Identifier: 188527855

GI number: 188527855

Start: 1087168

End: 1088514

Strand: Direct

Name: gdhA [H]

Synonym: HPSH_05515

Alternate gene names: 188527855

Gene position: 1087168-1088514 (Clockwise)

Preceding gene: 188527854

Following gene: 188527860

Centisome position: 67.59

GC content: 44.32

Gene sequence:

>1347_bases
ATGTATATTGAAAAAATCCTCCAATCTTTACAGAAAAAATACCCCTATCAAAAAGAGTTCCATCAAGCCGTCTGTGAAGC
TATCACTTCTTTAAAACCCCTTTTAGACAGCGATAAAAGTTATGAAAAGCATGCCATTTTAGAGCGTTTGATTGAGCCTG
AAAGGGAGATTTTTTTTAGGGTGTGTTGGCTGGATGATAACAACCAGATTCAGGTCAATCGGGGGTGTAGGGTTGAATTC
AATTCAGCGATTGGCCCTTATAAGGGGGGTTTGAGATTCCACCCTAGCGTGAATGAAAGCGTGATCAAGTTTTTAGGCTT
TGAGCAAGTGTTGAAAAATTCGCTCACCACTTTGGCTATGGGGGGCGCTAAGGGGGGGAGCGATTTTGACCCTAAAGGAA
AGAGCGAGCATGAGATCATGCGTTTTTGCCAGGCGTTCATGAATGAATTATACCGCCATATTGGGGCTACGACTGATGTG
CCAGCCGGGGATATTGGAGTGGGCGAAAGAGAGATTGGCTATCTGTTTGGGCAATACAAAAAATTAGTCAATCGTTTTGA
GGGCGTATTGACCGGTAAAGGGCTCACTTATGGGGGGAGCTTGTGCAGAAAAGAAGCTACCGGCTATGGGTGCGTGTATT
TTGCTGAAGAAATGTTGCAAGAAAGGAACAGCTCTTTAGAGGGTAAGGTTTGCAGCGTTTCTGGGAGCGGTAATGTCGCT
ATTTATACCATTGAAAAATTGCTTCAAATAGGAGCCAAACCGATAACGGCGAGCGATTCTAATGGCATGATTTATGATAA
AGACGGCATTGATTTAGAGCTTTTGAAAGAGATTAAAGAAATCCGTCGTGGGAGAATCAAAGAGTACGCCCTACAAAAAC
CAAACGCGAAATACACCCCCACAGAAAATTACCCCAAAGGGGGAAATGCTATATGGCATGTGCCTTGTTTTGCGGCTTTT
CCTAGCGCGACCGAGAATGAATTGGGCGTTTTAGACGCTAAAACCCTCCTTTCTAACGGGTGTAAATGCGTGGCTGAAGG
GGCGAACATGCCCTCAAGCAATGAAGCGATTGAATTGTTTTTACAGGCTAAGATTTCTTATGGCATAGGCAAGGCGGCTA
ATGCTGGGGGAGTGAGCGTGAGCGGCTTGGAAATGGCGCAAAATGCGAGCATGCACCCTTGGAGTTTTGAAGTGGTGGAT
GCGAAATTGTACCACATCATGAAAGAGATTTATAAGAATGTTTCTCAAACCGCTAAAGAATTTAAAGACCCTACTAATTT
TGTTTTAGGGGCCAATATCGCTGGTTTTAGAAAAGTAGCGTCGGCGATGATAGCGCAAGGGGTTTGA

Upstream 100 bases:

>100_bases
GTTTATAGGCGTTTTAAAAAGTTTTTTAAGATAAAGTTAAAACTTAATTACCCTTTTAGTGTTACAATAAAAACACTTAA
AACCATAAAGGATGTTGCTT

Downstream 100 bases:

>100_bases
TTGGTTTTACAAACCTATTTTTTAACCCACCTCCTTATGGTGCATAGCAAGGGTAAGGATTTTTGATAAGCTTTGCGATA
GATTTTAAAAGAGGTGTTCT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MYIEKILQSLQKKYPYQKEFHQAVCEAITSLKPLLDSDKSYEKHAILERLIEPEREIFFRVCWLDDNNQIQVNRGCRVEF
NSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAMGGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDV
PAGDIGVGEREIGYLFGQYKKLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVA
IYTIEKLLQIGAKPITASDSNGMIYDKDGIDLELLKEIKEIRRGRIKEYALQKPNAKYTPTENYPKGGNAIWHVPCFAAF
PSATENELGVLDAKTLLSNGCKCVAEGANMPSSNEAIELFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVD
AKLYHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQGV

Sequences:

>Translated_448_residues
MYIEKILQSLQKKYPYQKEFHQAVCEAITSLKPLLDSDKSYEKHAILERLIEPEREIFFRVCWLDDNNQIQVNRGCRVEF
NSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAMGGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDV
PAGDIGVGEREIGYLFGQYKKLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVA
IYTIEKLLQIGAKPITASDSNGMIYDKDGIDLELLKEIKEIRRGRIKEYALQKPNAKYTPTENYPKGGNAIWHVPCFAAF
PSATENELGVLDAKTLLSNGCKCVAEGANMPSSNEAIELFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVD
AKLYHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQGV
>Mature_448_residues
MYIEKILQSLQKKYPYQKEFHQAVCEAITSLKPLLDSDKSYEKHAILERLIEPEREIFFRVCWLDDNNQIQVNRGCRVEF
NSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAMGGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDV
PAGDIGVGEREIGYLFGQYKKLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVA
IYTIEKLLQIGAKPITASDSNGMIYDKDGIDLELLKEIKEIRRGRIKEYALQKPNAKYTPTENYPKGGNAIWHVPCFAAF
PSATENELGVLDAKTLLSNGCKCVAEGANMPSSNEAIELFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVD
AKLYHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQGV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=368, Percent_Identity=30.1630434782609, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4885281, Length=368, Percent_Identity=29.8913043478261, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1788059, Length=449, Percent_Identity=58.1291759465479, Blast_Score=505, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17544676, Length=340, Percent_Identity=29.1176470588235, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=47.5770925110132, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6324951, Length=452, Percent_Identity=47.5663716814159, Blast_Score=353, Evalue=4e-98,
Organism=Drosophila melanogaster, GI45549226, Length=407, Percent_Identity=28.2555282555283, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45553475, Length=407, Percent_Identity=28.2555282555283, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24649460, Length=324, Percent_Identity=29.6296296296296, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24649283, Length=317, Percent_Identity=28.7066246056782, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49438; Mature: 49438

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIEKILQSLQKKYPYQKEFHQAVCEAITSLKPLLDSDKSYEKHAILERLIEPEREIFFR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHEEEE
VCWLDDNNQIQVNRGCRVEFNSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAM
EEEECCCCEEEECCCCEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEE
GGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDVPAGDIGVGEREIGYLFGQYK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVA
HHHHHHHHHEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
IYTIEKLLQIGAKPITASDSNGMIYDKDGIDLELLKEIKEIRRGRIKEYALQKPNAKYTP
EEEHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCC
TENYPKGGNAIWHVPCFAAFPSATENELGVLDAKTLLSNGCKCVAEGANMPSSNEAIELF
CCCCCCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
LQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVDAKLYHIMKEIYKNVSQTAKE
HHHHHHHCCCCCCCCCCCEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FKDPTNFVLGANIAGFRKVASAMIAQGV
HCCCCCEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYIEKILQSLQKKYPYQKEFHQAVCEAITSLKPLLDSDKSYEKHAILERLIEPEREIFFR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHEEEE
VCWLDDNNQIQVNRGCRVEFNSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAM
EEEECCCCEEEECCCCEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEE
GGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDVPAGDIGVGEREIGYLFGQYK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVA
HHHHHHHHHEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
IYTIEKLLQIGAKPITASDSNGMIYDKDGIDLELLKEIKEIRRGRIKEYALQKPNAKYTP
EEEHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCC
TENYPKGGNAIWHVPCFAAFPSATENELGVLDAKTLLSNGCKCVAEGANMPSSNEAIELF
CCCCCCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
LQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVDAKLYHIMKEIYKNVSQTAKE
HHHHHHHCCCCCCCCCCCEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FKDPTNFVLGANIAGFRKVASAMIAQGV
HCCCCCEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]