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The map label for this gene is hemK [H]

Identifier: 188527854

GI number: 188527854

Start: 1086271

End: 1087101

Strand: Direct

Name: hemK [H]

Synonym: HPSH_05510

Alternate gene names: 188527854

Gene position: 1086271-1087101 (Clockwise)

Preceding gene: 188527853

Following gene: 188527855

Centisome position: 67.53

GC content: 37.42

Gene sequence:

>831_bases
ATGACCCTTTCACAAGCCCTAAACAAAGCCAAAAAAGAATTATCGCAAAAAGGTTTTAGAGGGGGATTAGAATCTGAAAT
TTTATTAGGCTTTGTCTTGCAAAAAGAAAGGGTTTTTTTGCACACGCATGCTTATTTAGAGTTAAACCACGAAGAAGAGG
TGTGCTTTTTTGAATTGGTAGAAAAGCGTTTGAATGACTGCCCCATAGAGTATTTATTAGAAAGCTGTGATTTTTATGGG
CGCTCTTTTTTCGTGAATGAGCATGTTTTAATCCCACGGCCTGAAACGGAGATTTTAGTCAAAAAAGCCCTTGATATTAT
TTCTCAATACCATTTAAAAGAAATAGGCGAAATAGGCATAGGGAGTGCTTGCGTGTCTGTTAGTTTGGCTTTAGAAAACC
CCAAAATTTCCATTCATGCGAGCGATATTTCATTAAAAGCTTTAGAAGTGGCGTCCAAAAATATTGAACGCTTTAATTTA
AAAGAGCGTGTTTTCTTAAAAAAAACGCGCCTTTGGGATCGCATGCCAACGATACAAATGCTTGTCTCTAACCCGCCCTA
TATCGCTAGAGGTTATCCTTTGGAAAAATCCGTTCTCAAAGAACCGCATGAAGCCCTTTTTGGGGGGGTTAAAGGCGATG
AAATCTTAAAAGAAATCGTTTTTTTAGCCGCTGCATTAAAAATCCCTTTTTTGGCTTGTGAAATGGGGCATGATCAGTTA
AAAAGCTTGAAAGAATGCTTGGAATTTTGCGGTTATGATGCGGAATTTTACAAGGATTTGAGCGGCTTTGATAGAGGGTT
TATAGGCGTTTTAAAAAGTTTTTTAAGATAA

Upstream 100 bases:

>100_bases
AGAATAAAGCGTTCCCCTATTCGCACCCTTTTTATGTTTTCTTGCATTTCACGCACCCGCCCTTATTAGAGCGCTTGAAA
GCTTTGGATTATGAAATTGA

Downstream 100 bases:

>100_bases
AGTTAAAACTTAATTACCCTTTTAGTGTTACAATAAAAACACTTAAAACCATAAAGGATGTTGCTTATGTATATTGAAAA
AATCCTCCAATCTTTACAGA

Product: protoporphyrinogen oxidase (hemK)

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLSQALNKAKKELSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVCFFELVEKRLNDCPIEYLLESCDFYG
RSFFVNEHVLIPRPETEILVKKALDIISQYHLKEIGEIGIGSACVSVSLALENPKISIHASDISLKALEVASKNIERFNL
KERVFLKKTRLWDRMPTIQMLVSNPPYIARGYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAALKIPFLACEMGHDQL
KSLKECLEFCGYDAEFYKDLSGFDRGFIGVLKSFLR

Sequences:

>Translated_276_residues
MTLSQALNKAKKELSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVCFFELVEKRLNDCPIEYLLESCDFYG
RSFFVNEHVLIPRPETEILVKKALDIISQYHLKEIGEIGIGSACVSVSLALENPKISIHASDISLKALEVASKNIERFNL
KERVFLKKTRLWDRMPTIQMLVSNPPYIARGYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAALKIPFLACEMGHDQL
KSLKECLEFCGYDAEFYKDLSGFDRGFIGVLKSFLR
>Mature_275_residues
TLSQALNKAKKELSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVCFFELVEKRLNDCPIEYLLESCDFYGR
SFFVNEHVLIPRPETEILVKKALDIISQYHLKEIGEIGIGSACVSVSLALENPKISIHASDISLKALEVASKNIERFNLK
ERVFLKKTRLWDRMPTIQMLVSNPPYIARGYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAALKIPFLACEMGHDQLK
SLKECLEFCGYDAEFYKDLSGFDRGFIGVLKSFLR

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=274, Percent_Identity=28.4671532846715, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787463, Length=256, Percent_Identity=28.90625, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082085, Length=206, Percent_Identity=30.5825242718447, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31460; Mature: 31329

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSQALNKAKKELSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVCFFELV
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEEEEECCCCCHHHHHHH
EKRLNDCPIEYLLESCDFYGRSFFVNEHVLIPRPETEILVKKALDIISQYHLKEIGEIGI
HHHHCCCCHHHHHHHHHHCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GSACVSVSLALENPKISIHASDISLKALEVASKNIERFNLKERVFLKKTRLWDRMPTIQM
CHHHHEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHH
LVSNPPYIARGYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAALKIPFLACEMGHDQL
HCCCCCCEECCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KSLKECLEFCGYDAEFYKDLSGFDRGFIGVLKSFLR
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC
>Mature Secondary Structure 
TLSQALNKAKKELSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVCFFELV
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEEEEECCCCCHHHHHHH
EKRLNDCPIEYLLESCDFYGRSFFVNEHVLIPRPETEILVKKALDIISQYHLKEIGEIGI
HHHHCCCCHHHHHHHHHHCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GSACVSVSLALENPKISIHASDISLKALEVASKNIERFNLKERVFLKKTRLWDRMPTIQM
CHHHHEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHH
LVSNPPYIARGYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAALKIPFLACEMGHDQL
HCCCCCCEECCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KSLKECLEFCGYDAEFYKDLSGFDRGFIGVLKSFLR
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]