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The map label for this gene is virB11 [H]

Identifier: 188527691

GI number: 188527691

Start: 900387

End: 901328

Strand: Reverse

Name: virB11 [H]

Synonym: HPSH_04565

Alternate gene names: 188527691

Gene position: 901328-900387 (Counterclockwise)

Preceding gene: 188527692

Following gene: 188527690

Centisome position: 56.03

GC content: 31.85

Gene sequence:

>942_bases
ATGATTTCTAATCTTTTAAAAAGTTACCTTGATGACTTTATGCCTATTTTAAGCCAGCCTAATTTAAATGAAGTGGTTTT
TAATAAAGAAAAAGAGTATTTCTTGCACCGCCCAAAGGAAAAAGTGAGGTGTTTTAATGAAAAATTTACTAATGATTATT
TGTTAGTTTTTTGTGAGCAATTAGCCATTTTTAGAAACCAAAAATTCACTCTAAAAACGCCTAAGTTAAACACTTCTTTG
CCTTACACACAAATTAGAATTAACGCATTACACCCTAGCATTATTGCTAGTTCTAATATTTCTATCAATATCAGAGTGCC
TAGCAATTTCAAGTTTGAAATTAACGCCTTTAAATTAAGTGAGAAATGTCTGGCTAAAAACATTACCCATGATTTTTTAC
TTAGCTTAGTAAGTGCAGGTAAAAATATTTTAATAAGTGGTGGCACAGCTAGTGGCAAGACTAGCTTTGTTAATTCTTTG
ATTGAAAATATCCCCAAAAACGAAAGGGTGGTTACTATTGAAGATAGTCCTGAGTTAAAAATCAGTAACGAAGACCAAGT
TAATATTTTAGTAGATAAAAGTGGGAGCGGATTTTTTACTTATGAAGATGGATTAAATGCGGCTATGAGAATGTCTCCTG
ATAGATTATTATTAGGTGAAATTGACACGCATAATACTGCGTTATTTTTGCGTTTAGCAAATACTGGGCATAGCGGAATG
ATAAGCACCTTACACGCCAATAGTGTAGCAGATGCTTTTATAGCTATTTGTCAGAATATAAACTTGAATAAAGGCGGTAA
GCCTACGCCTAAAGAAACGCTTTTAGATTATTTTTGCACTGGTATGGACTATGTTATCCAAATCAAAAAAAAAGGTAGTG
ATAGGATAATTGATGATGTTTTAAATGTTAAAAGCGAATTTAAAAAGGAGTTGATGTTATGA

Upstream 100 bases:

>100_bases
ATTCTTTAGCTAAAAGAATAGAAGATAAAAGAGAAAAAGAGCGCATTGAATTTCAAAAAAAAATGTTAAGGGATTTTGAT
AATCATCAAGGAGAGCCATA

Downstream 100 bases:

>100_bases
AAAATCCAAGACTTTATAGAAAATCTAAACAAAAAGTTGGTGCTAAAAGGATGGAATTTTTATTGGATGTTAGATGTGTC
CAAATTTTAAATGATTTAAA

Product: VIRB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MISNLLKSYLDDFMPILSQPNLNEVVFNKEKEYFLHRPKEKVRCFNEKFTNDYLLVFCEQLAIFRNQKFTLKTPKLNTSL
PYTQIRINALHPSIIASSNISINIRVPSNFKFEINAFKLSEKCLAKNITHDFLLSLVSAGKNILISGGTASGKTSFVNSL
IENIPKNERVVTIEDSPELKISNEDQVNILVDKSGSGFFTYEDGLNAAMRMSPDRLLLGEIDTHNTALFLRLANTGHSGM
ISTLHANSVADAFIAICQNINLNKGGKPTPKETLLDYFCTGMDYVIQIKKKGSDRIIDDVLNVKSEFKKELML

Sequences:

>Translated_313_residues
MISNLLKSYLDDFMPILSQPNLNEVVFNKEKEYFLHRPKEKVRCFNEKFTNDYLLVFCEQLAIFRNQKFTLKTPKLNTSL
PYTQIRINALHPSIIASSNISINIRVPSNFKFEINAFKLSEKCLAKNITHDFLLSLVSAGKNILISGGTASGKTSFVNSL
IENIPKNERVVTIEDSPELKISNEDQVNILVDKSGSGFFTYEDGLNAAMRMSPDRLLLGEIDTHNTALFLRLANTGHSGM
ISTLHANSVADAFIAICQNINLNKGGKPTPKETLLDYFCTGMDYVIQIKKKGSDRIIDDVLNVKSEFKKELML
>Mature_313_residues
MISNLLKSYLDDFMPILSQPNLNEVVFNKEKEYFLHRPKEKVRCFNEKFTNDYLLVFCEQLAIFRNQKFTLKTPKLNTSL
PYTQIRINALHPSIIASSNISINIRVPSNFKFEINAFKLSEKCLAKNITHDFLLSLVSAGKNILISGGTASGKTSFVNSL
IENIPKNERVVTIEDSPELKISNEDQVNILVDKSGSGFFTYEDGLNAAMRMSPDRLLLGEIDTHNTALFLRLANTGHSGM
ISTLHANSVADAFIAICQNINLNKGGKPTPKETLLDYFCTGMDYVIQIKKKGSDRIIDDVLNVKSEFKKELML

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 35236; Mature: 35236

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNLLKSYLDDFMPILSQPNLNEVVFNKEKEYFLHRPKEKVRCFNEKFTNDYLLVFCEQ
CHHHHHHHHHHHHHHHHCCCCCCHHEECCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
LAIFRNQKFTLKTPKLNTSLPYTQIRINALHPSIIASSNISINIRVPSNFKFEINAFKLS
HHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCEEECCCCEEEEEECCCCEEEEEEEEHH
EKCLAKNITHDFLLSLVSAGKNILISGGTASGKTSFVNSLIENIPKNERVVTIEDSPELK
HHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE
ISNEDQVNILVDKSGSGFFTYEDGLNAAMRMSPDRLLLGEIDTHNTALFLRLANTGHSGM
ECCCCEEEEEEECCCCEEEEECCCCCHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCC
ISTLHANSVADAFIAICQNINLNKGGKPTPKETLLDYFCTGMDYVIQIKKKGSDRIIDDV
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
LNVKSEFKKELML
HHHHHHHHHHHCC
>Mature Secondary Structure
MISNLLKSYLDDFMPILSQPNLNEVVFNKEKEYFLHRPKEKVRCFNEKFTNDYLLVFCEQ
CHHHHHHHHHHHHHHHHCCCCCCHHEECCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
LAIFRNQKFTLKTPKLNTSLPYTQIRINALHPSIIASSNISINIRVPSNFKFEINAFKLS
HHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCEEECCCCEEEEEECCCCEEEEEEEEHH
EKCLAKNITHDFLLSLVSAGKNILISGGTASGKTSFVNSLIENIPKNERVVTIEDSPELK
HHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE
ISNEDQVNILVDKSGSGFFTYEDGLNAAMRMSPDRLLLGEIDTHNTALFLRLANTGHSGM
ECCCCEEEEEEECCCCEEEEECCCCCHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCC
ISTLHANSVADAFIAICQNINLNKGGKPTPKETLLDYFCTGMDYVIQIKKKGSDRIIDDV
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
LNVKSEFKKELML
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]