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The map label for this gene is pepA [H]

Identifier: 188527583

GI number: 188527583

Start: 784933

End: 786423

Strand: Direct

Name: pepA [H]

Synonym: HPSH_04025

Alternate gene names: 188527583

Gene position: 784933-786423 (Clockwise)

Preceding gene: 188527582

Following gene: 188527584

Centisome position: 48.8

GC content: 40.64

Gene sequence:

>1491_bases
ATGTTGAAAATCAAATTAGAAAAAACCACCTTTGAAAACGCAAAAGCTGAATGCGGCTTAGTTTTTATTATCAATAAGGA
TTTTGATCACGCTTGGGTCAAAAATAAAAAATTGCTAGAAACCTTTAAATACGAAGGCGAAGGCGTGTTTTTAGACCAAG
AAAATAAAATCTTGTATGCGGGCGTTAAAGAAGACGATGTGCATTTATTAAGAGAGAGTGCATGTCTAGCCGTTCGCACC
CTTAAAAAACTCGCTTTTAAAAGCGTTAAAGTGGGGGTTTATACTTGCGACACGCATTCTAAAGATAATGCGCTTTTAGA
AAACTTGAAAGCGTTGTTTTTGGGCTTGAAATTAGGCTTGTATGAATACGACACTTTTAAATCCAACAAAAAAGAAAGCG
TTTTAAAAGAAGCAATTGTCGCTTTAGAATTGCACAAACCTTGCGAAAAAACTTGCGCAAATTCTTTAGAAAAGAGCGCT
AAAGAAGCTTTAAAATACGCTGAAATCATGACAGAAAGCTTGAATATCGTTAGGGATCTAGTCAATACCCCCCCTATGAT
TGCCACCCCGGTTTATATGGCTGAAGTGGCGCAAAAAGTGGCTAAAGAAAACCATTTAGAAATCCATGTTCATGATGAAA
AATTTTTAGAAGAAAAGAAAATGAACGCCTTTTTAGCGGTCAATAAAGCCTCTCTTGGCGTCAATCCTCCTCGCTTGATT
CATTTAGTCTATAAGCCTAAAAAAGCGAAGAAAAAAATCGCTTTAGTGGGTAAGGGATTGACTTATGATTGCGGGGGTTT
GAGCTTGAAACCCGCCGATTACATGGTTACCATGAAAGCGGATAAAGGCGGTGGATCTGCGGTGATTGGGCTTTTAAACG
CGTTAGCCAAATTGGGCGTGGAAGCTGAAGTGCATGGCATTATTGGGGCTACAGAAAACATGATAGGCCCGGCCGCTTAT
AAACCAGATGATATTTTAATCTCCAAAGAAGGCAAGAGCATAGAGGTGCGCAATACCGACGCTGAAGGGCGCTTGGTTTT
AGCGGATTGTTTGAGCTACGCTCAAGACTTAAGCCCTGATGTGATCGTGGATTTTGCGACCCTTACTGGGGCATGCGTTG
TAGGCTTAGGCGAATTCACTTCAGCGATCATGGGGCATAATGAAGAGTTAAAAAACCTCTTTGAAACTTCAGGGTTAGAA
TCCGGCGAATTATTAGCCAAACTCCCCTTTAACCGCCATTTAAAGAAATTGATCGAATCTAAAATCGCTGATGTGTGCAA
TATTTCTTCTTCACGCTATGGCGGTGCGATCACAGCGGGCTTGTTTTTAAATGAATTTATTAGAGATGAGTTTAAGGATA
AGTGGTTACACATTGACATTGCAGGCCCTGCTTATGTGGAAAAAGAATGGGATGTGAATAGCTTTGGAGCGAGTGGGGCT
GGGGTTAGGGCTTGCACAGCTTTTGTGGAAGAATTTTTGAAAAAGGCTTGA

Upstream 100 bases:

>100_bases
CTATGGTATTTCCAATACTATAGTAAGAAAAACCGCTAGAGTGCAATACAATTCTAGTTGAAAGATATGAAATAGATATG
AAATTAAAAAAGGAGACTTT

Downstream 100 bases:

>100_bases
AATGGGCTTGTCTGTAGGCATTGTGGGTTTGCCTAATGTGGGCAAATCCAGCACCTTTAACGCGCTCACTAAAACCCAAA
ACGCAGAGAGCGCGAACTAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEEFLKKA

Sequences:

>Translated_496_residues
MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEEFLKKA
>Mature_496_residues
MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEEFLKKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=429, Percent_Identity=33.7995337995338, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI47155554, Length=299, Percent_Identity=36.4548494983278, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1790710, Length=379, Percent_Identity=34.5646437994723, Blast_Score=219, Evalue=5e-58,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=33.7539432176656, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=36.8770764119601, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=228, Percent_Identity=32.4561403508772, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357381, Length=298, Percent_Identity=35.2348993288591, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI221379063, Length=298, Percent_Identity=35.2348993288591, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI221379062, Length=298, Percent_Identity=35.2348993288591, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21355725, Length=352, Percent_Identity=30.6818181818182, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24661038, Length=352, Percent_Identity=30.3977272727273, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19922386, Length=357, Percent_Identity=25.2100840336134, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20129969, Length=299, Percent_Identity=26.7558528428094, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24662227, Length=357, Percent_Identity=24.9299719887955, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129963, Length=292, Percent_Identity=29.1095890410959, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161077148, Length=308, Percent_Identity=25.6493506493506, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20130057, Length=308, Percent_Identity=25.6493506493506, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355645, Length=351, Percent_Identity=24.5014245014245, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24662223, Length=351, Percent_Identity=24.5014245014245, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646701, Length=350, Percent_Identity=29.1428571428571, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646703, Length=350, Percent_Identity=29.1428571428571, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21358201, Length=350, Percent_Identity=29.1428571428571, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54538; Mature: 54538

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYA
CEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCEEEEECCCEEEEE
GVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
YEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVRDL
EECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCEE
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGV
EEEECCCHHHCEEEEEECCCEECCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
EAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPD
CEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCC
VIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIES
CEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCCC
GVRACTAFVEEFLKKA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYA
CEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCEEEEECCCEEEEE
GVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
YEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVRDL
EECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCEE
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGV
EEEECCCHHHCEEEEEECCCEECCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
EAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLSPD
CEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCC
VIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIES
CEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCCC
GVRACTAFVEEFLKKA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA