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The map label for this gene is pyrC [H]

Identifier: 188527572

GI number: 188527572

Start: 775584

End: 776603

Strand: Direct

Name: pyrC [H]

Synonym: HPSH_03970

Alternate gene names: 188527572

Gene position: 775584-776603 (Clockwise)

Preceding gene: 188527571

Following gene: 188527573

Centisome position: 48.22

GC content: 40.39

Gene sequence:

>1020_bases
ATGGAAATCACGCTTTTTGACCCTATAGACGCCCACTTGCATGTGCGAGAAAACGCGCTTTTAAAAGCGGTGTTAAGATA
TTCTAGCGAGCCTTTTAGCGCTGCGGTGATCATGCCTAATCTCAGTAAGCCCTTAATCAACACTCCAACCACCCTTGAAT
ACGAAGAAGAAATTTTAAACCATTCTTCAAACTTCAAGCCTTTAATGAGTTTGTATTTTAATGATGGCTTGACTTTAGAA
GAATTGCAACGCGCCCAAGAAAAAGGCGTCAGGTTTTTAAAGCTCTACCCCAAAGGCATGACCACAAACGCGCAAAACGG
CACTTCGGATTTGTTGGGTGAAAAAACTTTAGAGATTTTAGAAAACGCCCAAAAATTAGGCTTTATTTTATGCATCCACG
CAGAACAAGCCGGGTTTTGTTTGGATAAAGAATTTTTATGCCATAGCGTTTTAGAAACTTTCGCGCTTTCATTCCCTAAA
CTCAAAATCATTATAGAGCATTTGAGCGATTGGCGCAGTATCGCTTTAATTGAAAAGCATGACAACCTCTATGCGACTTT
AACTTTACACCATATCAGCATGACCTTAGATGATTTATTAGGGGGGAGTTTGAACCCGCATTGTTTTTGCAAACCTTTAA
TCAAAACCAAAAAAGACCAAGAAAGGCTTTTATCCCTTGCTTTAAAAGCCCACCCTAAAATCTCTTTTGGCTCTGATAGC
GCCCCGCATTTTATCTCTAAAAAGCATAGCGCTAACATCCCAGCAGGCATCTTTTCTGCCCCTATTTTGTTGCCTGCGTT
GTGCGAACTTTTTGAAAAACACAACGCTTTAGAAAACTTGCAAGCCTTTATCAGCGATAACGCTAAAAAAATCTACGCAC
TAGACAATTTGCCAGCTAAAAAGGTGCGTTTGTCTAAAACACCCTTTATAGTCCCCACGCACACGCTTTGTTTGAATGAA
AAAATCGCTATCTTAAGAGGGGGCGAAACGCTATCTTGGAACATTCAAGAAATCGCCTAA

Upstream 100 bases:

>100_bases
CTTAAAGACCATTCAGATCGCTTATAAGGATTACCCACGCCCCAAAACTAAAACCCTCATTCGCATTAGAGTGCGTTATT
ACTTAGGGGGCAATTAAAAA

Downstream 100 bases:

>100_bases
AGCATGCCGCCTTTTTTGTGGGGCTTTTTATCGTTTTATTTTTAATTATAATGAAGCGCCAAACCCCCCCCTATGCTTTT
ATGCACAATCAAACCCTTTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLINTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQRAQEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPAKKVRLSKTPFIVPTHTLCLNE
KIAILRGGETLSWNIQEIA

Sequences:

>Translated_339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLINTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQRAQEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPAKKVRLSKTPFIVPTHTLCLNE
KIAILRGGETLSWNIQEIA
>Mature_339_residues
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLINTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQRAQEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEILENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPAKKVRLSKTPFIVPTHTLCLNE
KIAILRGGETLSWNIQEIA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=341, Percent_Identity=30.2052785923754, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323452, Length=361, Percent_Identity=31.3019390581717, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006992
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF04909 Amidohydro_2 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37999; Mature: 37999

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLINTPTTLEYEEEILN
CEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
HSSNFKPLMSLYFNDGLTLEELQRAQEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEIL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPAK
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHH
KVRLSKTPFIVPTHTLCLNEKIAILRGGETLSWNIQEIA
HEEECCCCEEEECCEEEECCCEEEEECCCEEEEEHHCCC
>Mature Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLRYSSEPFSAAVIMPNLSKPLINTPTTLEYEEEILN
CEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
HSSNFKPLMSLYFNDGLTLEELQRAQEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEIL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQAGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKKIYALDNLPAK
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHH
KVRLSKTPFIVPTHTLCLNEKIAILRGGETLSWNIQEIA
HEEECCCCEEEECCEEEECCCEEEEECCCEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA