| Definition | Helicobacter pylori Shi470, complete genome. |
|---|---|
| Accession | NC_010698 |
| Length | 1,608,548 |
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The map label for this gene is nrdA [H]
Identifier: 188527475
GI number: 188527475
Start: 662322
End: 664688
Strand: Direct
Name: nrdA [H]
Synonym: HPSH_03465
Alternate gene names: 188527475
Gene position: 662322-664688 (Clockwise)
Preceding gene: 188527474
Following gene: 188527476
Centisome position: 41.18
GC content: 40.9
Gene sequence:
>2367_bases TTGATTACGGTGGTTAAACGAAACGGGCGCATTGAGCCTTTAGACATTACAAAAATCCAAAAATACACTAAGGACGCCAC GGACAATTTAGAGGGCGTGAGCCAAAGTGAGCTGGAAGTGGATGCGAGGTTGCAATTTAGGGACAAGATCACTACTGAAG AAATCCAGCAAACTTTGATTAAAACCGCTGTGGATAAGATAGATATTGACACGCCTAATTGGAGCTTTGTCGCCTCAAGG CTTTTTTTGTATGATTTATACCATAAAGTAAGTGGTTTTACAGGGTATAGGCATTTGAAAGAGTATTTTGAAAACGCTGA AGAAAAGGGCCGCATCCTTAAGGGCTTTAAGGAAAAATTTGATTTAGAGTTTTTAAATGGCCAGATCAAGCCTGAAAGGG ATTTCCAATTCAATTATTTAGGGATTAAAACCTTGTATGATCGCTATTTGTTAAAAGACGCCAACAATAACCCTATTGAA TTACCCCAACACATGTTTATGAGCATTGCGATGTTTTTAGCGCAAAACGAACAAGAACCTAATAAAATCGCTTTAGAATT TTATGAAGTTTTAAGCAAGTTTGAAGCGATGTGCGCGACCCCCACTCTAGCGAACGCTCGCACCACCAAGCACCAGCTAA GCTCATGCTATATTGGCAGCACGCCGGATAATATTGAGGGGATTTTTGACAGCTATAAGGAAATGGCGCTGTTGTCTAAA TACGGCGGGGGGATTGGCTGGGATTTTTCTTTGGTGCGCTCTATTGGGAGTTATATTGATGGGCATAAAAATGCGAGCGC TGGCACGATCCCTTTTTTAAAGATCGCTAATGATGTGGCGATTGCGGTGGATCAATTAGGCACACGAAAGGGCGCGATTG CGGTCTATTTGGAAATTTGGCACATTGATGTGATGGAGTTCATTGATTTAAGGAAAAATAGCGGCGATGAAAGGCGAAGA GCACATGATTTATTCCCAGCTCTTTGGGTGTGCGATTTGTTTATGAAAAGGGTTTTAGAAGATGCGATGTGGACTTTGTT TGACCCTTATGAGTGTAAGGATTTGACTGAGCTTTATGGGCAGGATTTTGAAAAACGCTATTTAGAATATGAAAAAGATC CTAAAATCATTAAAGAATACATTAACGCTAAAGATTTATGGAAAAAAATCTTAATGAATTATTTTGAAGCCGGCTTGCCT TTCTTGGCCTTTAAAGATAACGCCAATCGGTGCAATCCAAACGCTCATGCAGGCATTATTCGATCCAGCAATCTGTGCAC GGAGATTTTTCAAAATACCGCGCCTAACCACTACCGCATGCAGATAGAATACACCGATGGCGCCATAGAGTTTTTTGAAG AAAAGCAGTTGGTAACGACAGACAATAATATCACTAAATGCGCCAACAAGCTCACTAGCACGGATACTCTTAAGGGCAAG CAAATCTATATCGCTACTAAAGTCGCTAAAGACGGGCAAACGGCGGTGTGTAATCTGGCGAGCATCAATTTAAGCAAGAT CAACACTGAAGAAGACATTAAAAGGGTTGTGCCGATCATGGTTAGGCTTTTAGACAATGTAATTGATTTGAATTTCTACC CCAACCGCAAAGTCAAAGCCACCAATTTACAAAATAGAGCCATAGGGTTAGGGGTTATGGGTGAAGCGCAAATGCTCGCA GAGCATCAAATCGCTTGGGGGTCTAAAGAGCATTTAGAAAAAATTGACGCTTTAATGGAGCAAATCAGCTACCATGCGAT TGACACGAGCGCGAATTTAGCGAAAGAAAAAGGGGTTTATAAGGATTTTGAAAATTCAGAATGGAGTAAGGGGATTTTCC CCATTGATAAAGCCAATAATGAAGCCTTAAAGCTCACCGAAAAAGGGCTTTTTAACCACGCTTGCGATTGGCAAGGTTTG AGGGAAAAAGTCAAAGCCAATGGCATGCGTAATGGCTATTTAATGGCGATCGCTCCCACTAGCTCTATTTCTATTTTAGT AGGCACAACCCAAACGATTGAACCCATTTATAAGAAAAAATGGTTTGAAGAAAATTTGAGCGGGCTTATTCCTGTCGTAG TGCCTAATTTGAATTTAGAAACCTGGAATTTTTACACATCAGCCTATGATATTGACGCTAAAGATTTGATTAAAGCAGCG GCCGTGCGCCAAAAGTGGATCGATCAAGGCCAAAGCATTAATGTGTTTTTACGCATAGAAAACGCCAGCGGTAAAACCTT GCATGAAATTTACACGCTCGCTTGGAAATTAGGGTTAAAATCCACTTATTATTTGCGCAGCGAAAGCCCTAGCATAGATG AAAAAAGCGTGTTGGATCGATCGGTGGAGTGTTTTAATTGCCAATAA
Upstream 100 bases:
>100_bases TTAATAGAACAGATCCAACTTGAACTTTTCTTTTTCTTAAGTTTTTTATTGATACAATTCCAAATTTAAAAAACAAACGA TTTAATTCAAAGGAAAAATT
Downstream 100 bases:
>100_bases TATAAGCTTAAATAAGCTAATCTTTGCTAAAATGAGATTCAAAATTATTTAAGGAAGATGAATGCTTTTTGCTATGATTG GTTCAGGGGGGGTTATCGCT
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 788; Mature: 788
Protein sequence:
>788_residues MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNGQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR AHDLFPALWVCDLFMKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYRMQIEYTDGAIEFFEEKQLVTTDNNITKCANKLTSTDTLKGK QIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNLETWNFYTSAYDIDAKDLIKAA AVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ
Sequences:
>Translated_788_residues MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNGQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR AHDLFPALWVCDLFMKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYRMQIEYTDGAIEFFEEKQLVTTDNNITKCANKLTSTDTLKGK QIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNLETWNFYTSAYDIDAKDLIKAA AVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ >Mature_788_residues MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNGQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR AHDLFPALWVCDLFMKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYRMQIEYTDGAIEFFEEKQLVTTDNNITKCANKLTSTDTLKGK QIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNLETWNFYTSAYDIDAKDLIKAA AVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-cone domain [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=813, Percent_Identity=33.4563345633456, Blast_Score=376, Evalue=1e-104, Organism=Escherichia coli, GI2367133, Length=805, Percent_Identity=26.4596273291925, Blast_Score=283, Evalue=2e-77, Organism=Escherichia coli, GI1789030, Length=671, Percent_Identity=29.5081967213115, Blast_Score=260, Evalue=2e-70, Organism=Caenorhabditis elegans, GI17555242, Length=817, Percent_Identity=31.2117503059976, Blast_Score=362, Evalue=1e-100, Organism=Saccharomyces cerevisiae, GI6320914, Length=830, Percent_Identity=32.4096385542169, Blast_Score=381, Evalue=1e-106, Organism=Saccharomyces cerevisiae, GI6322123, Length=822, Percent_Identity=31.3868613138686, Blast_Score=373, Evalue=1e-104, Organism=Drosophila melanogaster, GI17352481, Length=810, Percent_Identity=31.6049382716049, Blast_Score=352, Evalue=5e-97,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 90185; Mature: 90185
Theoretical pI: Translated: 6.20; Mature: 6.20
Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHC DLEFLNGQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP CHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFMKRVLEDAMWTLFDPYECKDLTELYG HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE RSSNLCTEIFQNTAPNHYRMQIEYTDGAIEFFEEKQLVTTDNNITKCANKLTSTDTLKGK ECCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCC QIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA EEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNLETWNFYTSAYDIDAKDLIKAA CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECEECCCHHHHHHHH AVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC SVECFNCQ CCHHCCCC >Mature Secondary Structure MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHC DLEFLNGQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP CHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFMKRVLEDAMWTLFDPYECKDLTELYG HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE RSSNLCTEIFQNTAPNHYRMQIEYTDGAIEFFEEKQLVTTDNNITKCANKLTSTDTLKGK ECCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCC QIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA EEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNLETWNFYTSAYDIDAKDLIKAA CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECEECCCHHHHHHHH AVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC SVECFNCQ CCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]