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The map label for this gene is relA [H]

Identifier: 188527380

GI number: 188527380

Start: 564500

End: 566830

Strand: Direct

Name: relA [H]

Synonym: HPSH_02935

Alternate gene names: 188527380

Gene position: 564500-566830 (Clockwise)

Preceding gene: 188527379

Following gene: 188527381

Centisome position: 35.09

GC content: 38.65

Gene sequence:

>2331_bases
ATGAACGAAATTGATAAATCCGTTGATATCGGATTCTTACGGATTCTTGATGTTATTAAAAAAGTTACGACCCCAAAGGG
TGGCATTGAAATCTTAAGGACTTTAATTGATTTCACGCCCAAAATTGAAAACGCCCTAAATTTAGCGGCCAAAAGCCATA
AGGGGCAATACAGAAAAAGCGGCGAGCCTTATATTGTCCATCCTATTTGTGTGGCAAGCTTGGTAGCGTTTTGTGGGGGC
GATGAGGCGATGGTGTGCGCAGCGCTTTTGCATGATGTGGTAGAAGACACGCCCTGTAAAATTGAAACGATTGAGCAAGA
ATTTGGGCAAGATGTGGCTAATTTAGTGGATGCGCTCACTAAAATCACTGAAATCAGGAAAGAAGAGTTAGGAGTGAGCG
CTCAAGATCCCAGAATGGTGGTTTCAGCGCTCACTTTTAGAAAGATCCTAATTAGCGCGATACAAGATCCAAGAGCCTTA
GTGGTAAAGATTAGCGACAGGTTGCACAACATGCTCACCTTAGACGCCTTGCCTCATGACAAACAAGTGCGTATTTCTAA
AGAAACTCTAGCGGTGTATGCCCCCATAGCGAGCCGATTGGGCATGTCTTCAATTAAAAATGAATTAGAAGATAAGAGCT
TTTATTATATTTATCCAGAAGAGTATAAAAATATCAAGGAATATTTGCACAAAAACAAGCAGTCTTTACTCTTAAAACTC
AACGCTTTTGCGAGCAAGTTAGAAAAAAAACTTTTTGATAGCGGGTTTAGCCATTCGGATTTTAAACTCGTTACAAGGGT
GAAACGCCCTTACTCTATCCATCTTAAGATGCAACGAAAGGGCGCGGTTAATATTGATGAAATTTTGGACTTGTTAGCCA
TTAGGATTTTATTGAAAAACCCGATTGATTGCTATAAAGTTTTAGGGATTATCCATTTGAATTTCAAACCCATTGTTTCT
CGTTTTAAAGATTACATCGCTTTGCCCAAAGAAAATGGCTATAAGACGATACACACGACCATTTTTGATGAATCTTCTGT
TTATGAAGTGCAGATTCGCACCTTTGATATGCATATGGGGGCGGAGTATGGTAATTCAGCCCACTGGAAGTATAAAGCTG
GGGGCGTGGATAATGACGATCATCATGAGGGCATGAGATGGTTGCAAAATTTTAAATACCATGACAGCGACTTGAAAAAC
GACCCTAAGGAATTTTACGAACTCGCTAAGAACGATTTGTATCGTGAAGACATTGTCGTTTTTTCGCCCCATGGGGACAC
TTACACCTTACCGGTAGGAGCGATTGCTTTAGATTTTGCTTACATGGTGCATAGCGATTTAGGCGATAAAGCCACGGACG
CTTATATTAATAGTAAAAAAGCCTTACTCAATCAAGAATTAAGGAGTGGGGATGTGGTTAAAATCGTTAAAGGCGATAAA
GTAATACCTCGTTTCATTTGGATGGATCAGCTTAAAACTTCTAAGGCTAAAAACCATTTGCGCATCCAAAGAAGAAACCG
CTTGAAAGAAATTGACACTAAGAGCATGATCAATATCTTAGCGACTTTTTTTGGGCGCTCTGTTTTTGAAGATGTGGATT
TGAAAGATTACAAAAACTTTGAAGAAAGATTAACAGATTGTGGGGTGGAAACCACCTTAACAGAAGCGATGAAAACCTTT
GAAAATTTAGCCAAACTCACTGAAGAAATTGAAAATAAGGTGTTTTCTTTAAAAGAAGATGCGATTTTGGAATACCAAGA
GATGAGTTTATGGACTCGAGGTTTAAGGTATTTGGGTTTTAAAACCAGCGTTTTGAATTTTCTAACCCCAAACCGGCAGT
GGCAGTGTAAGGAATTAGAACATTTTAGCGTTTGTTCAAGCAACGCTTTAGAAATCAAACAGGTGTTGTTGAATGATTGT
TGTTACCCTAAATATGGCGATGAAATCATTGCGATTGTAACGGATTTAAAAGATCCAAAAGCGATTGCGCACCATAAATT
TTGCAAAAAAGCGATGGCGGAAGTGGATGCTAAAGTGCCGATGGTTTATATAGAATGGCACAAGCGGGATCGAACGATTT
ATAAAATGATGTTTTATTTAGGCGAAAAAAAGTCGGTTTTAGCAAGTTTATTGACTTTTTTAAACAGGAATGAATGCAAT
ATTGTGGGCGTGTCTTACTTAGGCTATAAAGACAAGTATTCTAGCCATTGTGAAGTGAGTTTTGAAATAGCTACGGATAA
GGCGGATTGGATCAGAGCCTTAATCAATCGCAAATATCAAGATAGGATTGTAGAATTATCCAGTCTGGATGATGCTTATG
AATTACAATAA

Upstream 100 bases:

>100_bases
GGAGCCAAAACTTTAGTGAATATGGATCCTAAACGCCATAAATTAGTGGATATTGCCATTAGAGAAATCGCTGAAGGGAA
AATTGATATAGACAGGATAG

Downstream 100 bases:

>100_bases
GCCCTAATTAAGGAATGAACATGGAACAAAAAATCAGTATCGCCTTAAAAGAGATCGCTAGAGGCGCTAATGAAATCATT
GGATTAGAATATATTGAAAA

Product: penta-phosphate guanosine-3'-pyrophosphohydrolase (spoT)

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLAAKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSAQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIHLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNDDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
VIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVDLKDYKNFEERLTDCGVETTLTEAMKTF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTSVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYELQ

Sequences:

>Translated_776_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLAAKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSAQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIHLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNDDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
VIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVDLKDYKNFEERLTDCGVETTLTEAMKTF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTSVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYELQ
>Mature_776_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLAAKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSAQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIHLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNDDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
VIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVDLKDYKNFEERLTDCGVETTLTEAMKTF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTSVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYELQ

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=700, Percent_Identity=32, Blast_Score=323, Evalue=3e-89,
Organism=Escherichia coli, GI1789147, Length=672, Percent_Identity=27.3809523809524, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24650996, Length=140, Percent_Identity=34.2857142857143, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 89263; Mature: 89263

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLAAKSHKGQYRKS
CCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GEPYIVHPICVASLVAFCGGDEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALT
CCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KITEIRKEELGVSAQDPRMVVSALTFRKILISAIQDPRALVVKISDRLHNMLTLDALPHD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHEEECCCCCC
KQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
CCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHH
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIHLKMQRKGAVNIDEILDLLAIRILLKN
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
PIDCYKVLGIIHLNFKPIVSRFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMG
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCEEEEEEEECCCCEEEEEEEEEEEECC
AEYGNSAHWKYKAGGVDNDDHHEGMRWLQNFKYHDSDLKNDPKEFYELAKNDLYREDIVV
CCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEE
FSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
ECCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
VIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVDLKDYKNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EERLTDCGVETTLTEAMKTFENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KTSVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDCCYPKYGDEIIAIVTDLKDPK
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCH
AIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECN
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYELQ
EEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLAAKSHKGQYRKS
CCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GEPYIVHPICVASLVAFCGGDEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALT
CCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KITEIRKEELGVSAQDPRMVVSALTFRKILISAIQDPRALVVKISDRLHNMLTLDALPHD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHEEECCCCCC
KQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
CCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHH
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIHLKMQRKGAVNIDEILDLLAIRILLKN
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
PIDCYKVLGIIHLNFKPIVSRFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMG
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCEEEEEEEECCCCEEEEEEEEEEEECC
AEYGNSAHWKYKAGGVDNDDHHEGMRWLQNFKYHDSDLKNDPKEFYELAKNDLYREDIVV
CCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEE
FSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
ECCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
VIPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVDLKDYKNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EERLTDCGVETTLTEAMKTFENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KTSVLNFLTPNRQWQCKELEHFSVCSSNALEIKQVLLNDCCYPKYGDEIIAIVTDLKDPK
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCH
AIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLASLLTFLNRNECN
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYELQ
EEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA