| Definition | Helicobacter pylori Shi470, complete genome. |
|---|---|
| Accession | NC_010698 |
| Length | 1,608,548 |
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The map label for this gene is cadA [H]
Identifier: 188527365
GI number: 188527365
Start: 545788
End: 547848
Strand: Direct
Name: cadA [H]
Synonym: HPSH_02860
Alternate gene names: 188527365
Gene position: 545788-547848 (Clockwise)
Preceding gene: 188527364
Following gene: 188527366
Centisome position: 33.93
GC content: 42.99
Gene sequence:
>2061_bases ATGCAAGAATACCACATTCATAATTTGGATTGCCCTGATTGCGCGTCTAAATTAGAAAGGGATTTAAACAAACTAGATTG TGTGAAAAAAGCTCAAATCAATTTCAGCACCAGTAAGTTGTTTTTGGATACGAGCGATTTTGAAAAAGTTAAGGCTTTCA TCAAGCAAAATGAACCGCATTTGAGCCTGTCTTTTAAAGAGGCTGCAGAAAAGCCCTTGAGTTTTACGCCACTCATTATT ACGATCCTTGTCTTTTTGGGCGCGATTTTAATCTTACACCTAAACCCTAGCCCCTTTATTGAAAAGGCTATGTTTTTCGT GTTGGCTATAGTGTATCTAGTGAGCGGTAAAGATGTGATTTTAGGGGCGTTTCGTGGGCTTAGAAAAGGGCAATTTTTTG ATGAAAACGCTTTGATGCTCATTGCGACTATTGCGGCTTTTTGCGTGGGGGCTTATGAAGAGAGCGTGTCTATTATGGTG TTTTATTCAGCGGGCGAATTTTTGCAAAAACTCGCTATCTCTCGCTCTAAAAAATCCCTTAAGGCTTTAGTGGATGTCGC TCCTAATTTGGCTTATTTGAAAAAGGGCGATGCGCTAGTGAGCGTTGCGCCTGAAGATTTAAGAGTCAATGACATTGTGG TGGTGAAAGTCGGCGAAAAAGTGCCTGTGGATGGCGTGGTGATTAAGGGCGAAAGTTTGCTAGATGAAAGGGCGTTGAGC GGGGAGTCTATGCCTGTTAATGTCAGCGAACGCTCTAAAGTTTTAGGGGGGAGCTTGAATTTAAAAGCGGTCCTTGAAAT TAAAGTAGAAAAAATGTATAAAGATTCTTCCATCGCTAAAGTGGTGGATTTAGTCCAACAAGCCACGAATGAAAAGAGCG AAACTGAGAAATTCATCACTAAATTTTCACGCTACTACACCCCAAGCGTTTTATTCATTGCGCTAATGATTGCTATATTA CCGCCCTTGTTTTCTATGGGGAGCTTTGATGAGTGGATTTATAGGGGGCTTGTGGCTTTAATGGTGAGCTGTCCTTGCGC GTTAGTGATTTCTGTGCCTTTAGGGTATTTTGGGGGCGTGGGAGCGGCGAGCAGAAAGGGCATTTTAATGAAAGGCGTGC ATGTTTTAGAGGTGCTTACCCAAGCTAAAAGCATCGCCTTTGATAAAACCGGCACTTTGACTAAAGGCGTTTTTAAAGTG ATAGATATTGTGCCGCAAAATGGGCATTCTAAAGAAGAAGTTTTGCATTATGCTTCTTGTTCGCAGCTTTTATCCACGCA CCCGATCGCTTTATCCATTCAAAAAGCATGCGAAGAAATGTTAAAGGACGATAAGCACCAGCATGACATTAAAAATTACG AAGAAGTGAGCGGAATGGGGGTTAAAGCGCAATGCGATACGGATTTAATCATCGCAGGGAATGAAAAAATGCTAGAACAA TTCAATATCGCGCACAGCCCTTCCCCAGAAAACGGCACGATCGTGCATGTGGCTTTCAATCAAACTTATGTGGGCTATAT CGTCATTAGCGATGAGATTAAAGATGACGCCATAGAGTGCTTAAGGGATTTAAAAGCGCAAGGGATAGAGAATTTTTGCA TTTTGAGCGGGGACAGAAAAAGCGCGACTGAGAGCATCGCCCAAACTTTAGGCTGTGAATATTATGCGAGCTTGTTGCCT GAAGAAAAAACGAGCGTGTTTAAAACTTTTAAAGAACGCTATAAAGCCCCGGCGATTTTTGTAGGCGATGGCATCAATGA CGCTCCGACTCTAGCGAGTGCTGATGTGGGGATTGGCATGGGGAAAGGCTCAGAATTGAGCAAGCAAAGCGCAGACATTG TGATCACTAATGACTCCTTAAGCTCTTTAGTGAAAGTTTTAGCGATCGCTAAAAAAACTAAAAGCATTATTTGGCAAAAT ATCTTGTTCGCTTTGGGGATTAAAGCCGTTTTTATCGTGCTAGGGCTTATGGGGGTAGCGAGCTTGTGGGAAGCGGTCTT TGGCGATGTGGGGGTTACGCTTTTAGCCTTAGCCAACTCCATGCGCGCGATGAGGGCTTAA
Upstream 100 bases:
>100_bases TGCGGATTTAAACGCTTGCGAGAATATAGAAAAATCTCACATGCTTAAAGCGCTGAGTTTTAGAAAGATTTCTTAAAAGG ATTTTTATAAGGGAGAGAAA
Downstream 100 bases:
>100_bases TGATCTTATTATCAGCCATTTAGAAGGGGGGCAAAATGCATAAAATAGAGCGCTTACTCCAAACTTTAGTGCCTAAGGGG GTGGAGTTTAAAACGCTTGA
Product: cadmium-transporting ATPase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 686; Mature: 686
Protein sequence:
>686_residues MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
Sequences:
>Translated_686_residues MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA >Mature_686_residues MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLII TILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMV FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV IDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQN ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]
COG id: COG2217
COG function: function code P; Cation transport ATPase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HMA domain [H]
Homologues:
Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=25.187969924812, Blast_Score=211, Evalue=2e-54, Organism=Homo sapiens, GI115529486, Length=706, Percent_Identity=26.2039660056657, Blast_Score=191, Evalue=2e-48, Organism=Homo sapiens, GI55743073, Length=518, Percent_Identity=27.2200772200772, Blast_Score=177, Evalue=2e-44, Organism=Escherichia coli, GI1789879, Length=690, Percent_Identity=33.9130434782609, Blast_Score=358, Evalue=1e-100, Organism=Escherichia coli, GI1786691, Length=505, Percent_Identity=28.7128712871287, Blast_Score=209, Evalue=7e-55, Organism=Escherichia coli, GI1786914, Length=513, Percent_Identity=25.1461988304094, Blast_Score=124, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17556548, Length=582, Percent_Identity=28.1786941580756, Blast_Score=180, Evalue=2e-45, Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.5925925925926, Blast_Score=208, Evalue=3e-54, Organism=Saccharomyces cerevisiae, GI6319772, Length=602, Percent_Identity=25.9136212624585, Blast_Score=176, Evalue=8e-45, Organism=Drosophila melanogaster, GI221329854, Length=524, Percent_Identity=24.0458015267176, Blast_Score=119, Evalue=1e-26,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008250 - InterPro: IPR001366 - InterPro: IPR006404 - InterPro: IPR006416 - InterPro: IPR001757 - InterPro: IPR018303 - InterPro: IPR005834 - InterPro: IPR023214 - InterPro: IPR017969 - InterPro: IPR006121 - InterPro: IPR000150 [H]
Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]
EC number: =3.6.3.3; =3.6.3.5 [H]
Molecular weight: Translated: 74841; Mature: 74841
Theoretical pI: Translated: 6.65; Mature: 6.65
Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC LSLSFKEAAEKPLSFTPLIITILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVI EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVIDIVPQNGHSKEEVLHYASC CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHH FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK HCCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC GKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLWEAVFGDVGVTLLALANSMRAMRA HHHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MQEYHIHNLDCPDCASKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC LSLSFKEAAEKPLSFTPLIITILVFLGAILILHLNPSPFIEKAMFFVLAIVYLVSGKDVI EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVIKGESLLDERALS HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVIDIVPQNGHSKEEVLHYASC CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCDTDLIIAGNEKMLEQ HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHH FNIAHSPSPENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK HCCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC GKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLWEAVFGDVGVTLLALANSMRAMRA HHHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]