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The map label for this gene is coaE

Identifier: 188527322

GI number: 188527322

Start: 512883

End: 513473

Strand: Direct

Name: coaE

Synonym: HPSH_02645

Alternate gene names: 188527322

Gene position: 512883-513473 (Clockwise)

Preceding gene: 188527321

Following gene: 188527323

Centisome position: 31.88

GC content: 37.23

Gene sequence:

>591_bases
ATGGTTTTAAAAAACGCTATCGCTCTAACAGGGGGGATAGGCACCGGTAAAAGCACCACCATTAAAATATTAGAATCGCA
AGGTTATCAAATTTTAGATGCGGATAAGATCGCTCATCAATTATTGCAAGAGCACCGGTTTAAAATCGCCCAACATTTTG
GATCAGATATTTTAGAAAAGGATATTTTAAACAGAAAAAAACTTGGCGCTATCGTGTTTCAAAATGCTAATGAATTAAAA
TGGCTAGAGGATTTTTTACACCCCTTAATCCGTGAGCGCATGCTTCAAAAAGCCTATGAATTAGAAAAGAATCATCAAGC
GTATTTTTTAGACATCCCTTTGTTTTTTGAAGTGGGGGGTAAAAAATGCTATCCTGTGAGTAAAGTGGTTTTAATCTATG
CACCCAGGGCCTTACAAATTGAGCGCCTTTTAGAGCGAGACAAACTCAAAGAAGCTGAAATCTTGCAGCGCTTAGCTTGT
CAAATGGATATAGAGCAAAAACGCGCCATGAGCGATTGCATTATAGACAACAGCTCCAGCTTAAAAGATTTAAATAAGCA
AGTTGAACGCTTTTTAAAAACGCTCTTATAA

Upstream 100 bases:

>100_bases
CTAAAAAGCGTGAGATACTATAACGAAGACATTCATAGGGCTGCATTCGCTTTGCCTAAAAATTTACAAGAAGTCTTTAA
AGACAATATCAAATCTTAAA

Downstream 100 bases:

>100_bases
GCTCGTTTTGTATCTAAGCATGTTAAACTACCATTAAATTTTTTGTAAGGCTAAAAACATGATCACTTTAAAACAAGCCC
TTTCTTTATCCCAAGATGAA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MVLKNAIALTGGIGTGKSTTIKILESQGYQILDADKIAHQLLQEHRFKIAQHFGSDILEKDILNRKKLGAIVFQNANELK
WLEDFLHPLIRERMLQKAYELEKNHQAYFLDIPLFFEVGGKKCYPVSKVVLIYAPRALQIERLLERDKLKEAEILQRLAC
QMDIEQKRAMSDCIIDNSSSLKDLNKQVERFLKTLL

Sequences:

>Translated_196_residues
MVLKNAIALTGGIGTGKSTTIKILESQGYQILDADKIAHQLLQEHRFKIAQHFGSDILEKDILNRKKLGAIVFQNANELK
WLEDFLHPLIRERMLQKAYELEKNHQAYFLDIPLFFEVGGKKCYPVSKVVLIYAPRALQIERLLERDKLKEAEILQRLAC
QMDIEQKRAMSDCIIDNSSSLKDLNKQVERFLKTLL
>Mature_196_residues
MVLKNAIALTGGIGTGKSTTIKILESQGYQILDADKIAHQLLQEHRFKIAQHFGSDILEKDILNRKKLGAIVFQNANELK
WLEDFLHPLIRERMLQKAYELEKNHQAYFLDIPLFFEVGGKKCYPVSKVVLIYAPRALQIERLLERDKLKEAEILQRLAC
QMDIEQKRAMSDCIIDNSSSLKDLNKQVERFLKTLL

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=189, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI191252795, Length=189, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI110227607, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI110227605, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI110227603, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI110227601, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI205277394, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786292, Length=189, Percent_Identity=30.6878306878307, Blast_Score=92, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554944, Length=197, Percent_Identity=29.4416243654822, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25143409, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=36.5, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644728, Length=183, Percent_Identity=34.9726775956284, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24658602, Length=197, Percent_Identity=31.4720812182741, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 22622; Mature: 22622

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKNAIALTGGIGTGKSTTIKILESQGYQILDADKIAHQLLQEHRFKIAQHFGSDILEK
CCCCCCEEEECCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHCHHHHHH
DILNRKKLGAIVFQNANELKWLEDFLHPLIRERMLQKAYELEKNHQAYFLDIPLFFEVGG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECC
KKCYPVSKVVLIYAPRALQIERLLERDKLKEAEILQRLACQMDIEQKRAMSDCIIDNSSS
CCCCHHHHEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
LKDLNKQVERFLKTLL
HHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVLKNAIALTGGIGTGKSTTIKILESQGYQILDADKIAHQLLQEHRFKIAQHFGSDILEK
CCCCCCEEEECCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHCHHHHHH
DILNRKKLGAIVFQNANELKWLEDFLHPLIRERMLQKAYELEKNHQAYFLDIPLFFEVGG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECC
KKCYPVSKVVLIYAPRALQIERLLERDKLKEAEILQRLACQMDIEQKRAMSDCIIDNSSS
CCCCHHHHEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
LKDLNKQVERFLKTLL
HHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]