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The map label for this gene is coaBC [H]

Identifier: 188527312

GI number: 188527312

Start: 503301

End: 504578

Strand: Reverse

Name: coaBC [H]

Synonym: HPSH_02595

Alternate gene names: 188527312

Gene position: 504578-503301 (Counterclockwise)

Preceding gene: 188527313

Following gene: 188527311

Centisome position: 31.37

GC content: 40.77

Gene sequence:

>1278_bases
ATGAATTTTTTAGAAGATTTGTTTTACCCCTTAAGATTATTAGAAAACAAGCGCGTTTTATTGCTCGTGAGCGGTTCTAT
TGCGGCGTATAAATCCCTAGAATTAGTGCGTTTGTTGTTTAAAAACGGGGCCAGTGTTCAAGTGGTGATGAGTGAGGGCG
CAAAAAAATTTGTTACTCCCTTAAGCTTTGAAGCCTTGAGCCATCACAAAGTCTTGCATGATCATAATGAAAAATGGTAT
TACAACCACCAAAACGCATTGCACCATAACCACATCGCATGCGCTACTGATTCTGATTTACTCATCTTTGCCCCTTTAAG
CGCTAACAGCCTGTCTAAAATCGCTCACGCTTTAGCGGATAATATCATAAGCGCGACTTTTTTAGCTTGCGCTTCCCCTA
AAATCCTAGCCCCTAGCATGAACACTAACATGCTCAATTCCCCTATCATTCAAAGCCATTTGAAACGCTTGAAAGATTTC
AATCACATTATTTTAGACACGCAAAACGGCCTTTTAGCATGCGATACTAAAGGCGATGGGGCGATGGCTGAGCCTTTAGA
AATCCTTTTTAAAGCCGCTCAAACGCTCTTAAAAGACGCTTATTTTGAAAACAGAGAAGTCATAATCATGGGCGGCGCGA
GTATAGAAAAGATTGACAGCGTTCGAACGATCAGCAACCTTTCTAGCGGGATCCAAGCGAGCGCTTTAGCTCTAGCGTTA
TATTTTAAGGGAGCGAAAGTAACCTTGATCGCATCAAACTTCCCTACCCCCTTGCCTAAAGAAATCGCAAGCGTTCCTGT
CAGCGACACTGCTTCTTATGAAAACGCCTTGAATAACGCCGCTAACAACCTGCAAAAACATGCCTTAAAACCCCTACTCT
TTAATTTAGCCGCCATTAGCGATTATGTGCCTAAAACTTCTTTTAACCATAAGCTTAAAAAAAGCGAATTGGGCGAAACC
CTAAACATTGAATGCGTTCAAAATAGGGATTTACTGGCTTCTATCAATCCCAATCAATTCGTTAAAATCGGCTTTAAAGC
CGAAGACGATCAACAAAACGCCATCAAAAACGCTCAAAATCTTTTAAAACCTTCTCAAGATAACGGCAAGGGTTGCTCCA
TGGTTGCTTTGAATCTCATTAAAGATTCACGCCCTTTTGGCTCATTAGAGAATGAATTGTGGCTCTTTAGCCATCACAAA
ACCCAAAAAATCCCTTCTATGAACAAATTAGAAGCGAGCTTTAAAATCCTTGATTTTATCAAAGACAACGCCCTTTAA

Upstream 100 bases:

>100_bases
CCAAACTCCACGAAAAAGGCCACAAAGTCGCCCCTGATTTTGAATACAGCAGCCATAATAACAGCAAATGGCTAGAGCCT
GATGATTTATTGAAATTGCT

Downstream 100 bases:

>100_bases
TGCTAGAAGCCCTAAACGCCATAAACCAGCTTAACGCTCTTCATTCCAAAAACGCCGTGCACCATTTTAACGCTACCTTA
CCCATTCTTTTAAAGGTTTT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKNGASVQVVMSEGAKKFVTPLSFEALSHHKVLHDHNEKWY
YNHQNALHHNHIACATDSDLLIFAPLSANSLSKIAHALADNIISATFLACASPKILAPSMNTNMLNSPIIQSHLKRLKDF
NHIILDTQNGLLACDTKGDGAMAEPLEILFKAAQTLLKDAYFENREVIIMGGASIEKIDSVRTISNLSSGIQASALALAL
YFKGAKVTLIASNFPTPLPKEIASVPVSDTASYENALNNAANNLQKHALKPLLFNLAAISDYVPKTSFNHKLKKSELGET
LNIECVQNRDLLASINPNQFVKIGFKAEDDQQNAIKNAQNLLKPSQDNGKGCSMVALNLIKDSRPFGSLENELWLFSHHK
TQKIPSMNKLEASFKILDFIKDNAL

Sequences:

>Translated_425_residues
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKNGASVQVVMSEGAKKFVTPLSFEALSHHKVLHDHNEKWY
YNHQNALHHNHIACATDSDLLIFAPLSANSLSKIAHALADNIISATFLACASPKILAPSMNTNMLNSPIIQSHLKRLKDF
NHIILDTQNGLLACDTKGDGAMAEPLEILFKAAQTLLKDAYFENREVIIMGGASIEKIDSVRTISNLSSGIQASALALAL
YFKGAKVTLIASNFPTPLPKEIASVPVSDTASYENALNNAANNLQKHALKPLLFNLAAISDYVPKTSFNHKLKKSELGET
LNIECVQNRDLLASINPNQFVKIGFKAEDDQQNAIKNAQNLLKPSQDNGKGCSMVALNLIKDSRPFGSLENELWLFSHHK
TQKIPSMNKLEASFKILDFIKDNAL
>Mature_425_residues
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKNGASVQVVMSEGAKKFVTPLSFEALSHHKVLHDHNEKWY
YNHQNALHHNHIACATDSDLLIFAPLSANSLSKIAHALADNIISATFLACASPKILAPSMNTNMLNSPIIQSHLKRLKDF
NHIILDTQNGLLACDTKGDGAMAEPLEILFKAAQTLLKDAYFENREVIIMGGASIEKIDSVRTISNLSSGIQASALALAL
YFKGAKVTLIASNFPTPLPKEIASVPVSDTASYENALNNAANNLQKHALKPLLFNLAAISDYVPKTSFNHKLKKSELGET
LNIECVQNRDLLASINPNQFVKIGFKAEDDQQNAIKNAQNLLKPSQDNGKGCSMVALNLIKDSRPFGSLENELWLFSHHK
TQKIPSMNKLEASFKILDFIKDNAL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=196, Percent_Identity=34.1836734693878, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082301, Length=339, Percent_Identity=33.0383480825959, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560194, Length=174, Percent_Identity=29.8850574712644, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=28.042328042328, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24657262, Length=177, Percent_Identity=31.0734463276836, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46883; Mature: 46883

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKNGASVQVVMSEGAKKFVTP
CCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCC
LSFEALSHHKVLHDHNEKWYYNHQNALHHNHIACATDSDLLIFAPLSANSLSKIAHALAD
CCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHH
NIISATFLACASPKILAPSMNTNMLNSPIIQSHLKRLKDFNHIILDTQNGLLACDTKGDG
HHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCC
AMAEPLEILFKAAQTLLKDAYFENREVIIMGGASIEKIDSVRTISNLSSGIQASALALAL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHEEE
YFKGAKVTLIASNFPTPLPKEIASVPVSDTASYENALNNAANNLQKHALKPLLFNLAAIS
EECCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYVPKTSFNHKLKKSELGETLNIECVQNRDLLASINPNQFVKIGFKAEDDQQNAIKNAQN
HHCCCCCCCCCCCHHHCCCEEEEEEECCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHH
LLKPSQDNGKGCSMVALNLIKDSRPFGSLENELWLFSHHKTQKIPSMNKLEASFKILDFI
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHH
KDNAL
HHCCC
>Mature Secondary Structure
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKNGASVQVVMSEGAKKFVTP
CCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCC
LSFEALSHHKVLHDHNEKWYYNHQNALHHNHIACATDSDLLIFAPLSANSLSKIAHALAD
CCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHH
NIISATFLACASPKILAPSMNTNMLNSPIIQSHLKRLKDFNHIILDTQNGLLACDTKGDG
HHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCC
AMAEPLEILFKAAQTLLKDAYFENREVIIMGGASIEKIDSVRTISNLSSGIQASALALAL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHEEE
YFKGAKVTLIASNFPTPLPKEIASVPVSDTASYENALNNAANNLQKHALKPLLFNLAAIS
EECCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYVPKTSFNHKLKKSELGETLNIECVQNRDLLASINPNQFVKIGFKAEDDQQNAIKNAQN
HHCCCCCCCCCCCHHHCCCEEEEEEECCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHH
LLKPSQDNGKGCSMVALNLIKDSRPFGSLENELWLFSHHKTQKIPSMNKLEASFKILDFI
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHH
KDNAL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]