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The map label for this gene is hldD [H]

Identifier: 188527296

GI number: 188527296

Start: 484464

End: 485456

Strand: Direct

Name: hldD [H]

Synonym: HPSH_02515

Alternate gene names: 188527296

Gene position: 484464-485456 (Clockwise)

Preceding gene: 188527295

Following gene: 188527297

Centisome position: 30.12

GC content: 38.17

Gene sequence:

>993_bases
ATGCGTTATATTGATGATGAGTTAGAAAATCAAACGATTTTAATCACCGGTGGGGCTGGCTTTGTAGGCAGTAATTTGGC
CTTTTATTTTCAAGAGAACCACCCTAAAGCTAAAGTGGTGGTTTTGGATAAGTTTCGCAATAACACGCTTTTCAGTAATA
ACCGTCCCAGTTCCTTAGGGCATTTTAAGAATTTAATCGGTTTTAAGGGTGAGGTGGTTATAGCTGATATTAATAACCCC
TTAGATTTAAGGCGTTTAGAAAAATTGCATTTTGATTATTTGTTCCACCAAGCCGCTATCTCTGATACGACCATGCTGGA
TCAAGAACTAGTGATGAAAACCAACTACCAGGCTTTTTTAAACCTTTTAGAAATCGCTCGCTCAAAAAAAGCTAAAGTGA
TTCACGCTTCTTCAGCGGGCGTTTATGGCAACACCAAAGCCCCCAATGTGGTAGGCAAAAACGAAAGCCCTGAAAATGTT
TATGGCTTTTCCAAGCTTTGCATGGACGAATTTGTCCTCTCTCATTCAAACGACAATATTCAAGTGGGCTTAAGGTATTT
TAATGTCTATGGGCCTAGGGAATTTTATAAAGAAAAAACCGCCTCTATGGTTTTGCAACTCGCCTTAGGCATAATGGCGT
TTAAGGAAGTCAAGCTTTTTGAATTTGGCGAGCAATTAAGGGATTTTGTTTATATTGAAGATGTGATCCAAGCGAATGTG
AAAGCGATGAAGGCTCAAAAAAGCGGGGTTTATAATGTGGGTTATTCTCAAGCCAGAAGTTATAATGAAATAGTTAGCAT
TTTAAAAGAGCATTTAGGGGATTTTAAAGTAGCTTATATCAAAAACCCTTATGCTTTCTTCCAAAATCACACCCAAGCGC
ATATTGAACCCACTATTTTGGATTTGGATTACACCCCTTTATACGATTTAGAAAGCGGCATTAAAGATTATTTGCCCCAT
ATCCGTGCGATTTTTAAAGAACATTGCGCATGA

Upstream 100 bases:

>100_bases
ACAACCTTTTATTGACCACAAATGTTTTAAAAACTCCTCATTCTTGGATACAATGTAAAGATTTTAAAGAGATAATAGAT
CTAATCAAATAAGGACAAGA

Downstream 100 bases:

>100_bases
AACAAATCTTAGTCGTGGGGGATCTGATCGCTGATTATTACCTGTGGGGGAGAAGCGAACGCCTTTCGCCTGAAGCCCCT
GTGCCTGTTTTAGAAGTCCA

Product: ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD)

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRNNTLFSNNRPSSLGHFKNLIGFKGEVVIADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIHASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFVLSHSNDNIQVGLRYFNVYGPREFYKEKTASMVLQLALGIMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVAYIKNPYAFFQNHTQAHIEPTILDLDYTPLYDLESGIKDYLPH
IRAIFKEHCA

Sequences:

>Translated_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRNNTLFSNNRPSSLGHFKNLIGFKGEVVIADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIHASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFVLSHSNDNIQVGLRYFNVYGPREFYKEKTASMVLQLALGIMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVAYIKNPYAFFQNHTQAHIEPTILDLDYTPLYDLESGIKDYLPH
IRAIFKEHCA
>Mature_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRNNTLFSNNRPSSLGHFKNLIGFKGEVVIADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIHASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFVLSHSNDNIQVGLRYFNVYGPREFYKEKTASMVLQLALGIMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVAYIKNPYAFFQNHTQAHIEPTILDLDYTPLYDLESGIKDYLPH
IRAIFKEHCA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=332, Percent_Identity=24.6987951807229, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790049, Length=317, Percent_Identity=29.9684542586751, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539532, Length=287, Percent_Identity=27.1777003484321, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115532424, Length=340, Percent_Identity=25, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=27.7945619335347, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37638; Mature: 37638

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRNNTLFSNNRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHH
HFKNLIGFKGEVVIADINNPLDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIHASSAGVYGNTKAPNVVGKNESPENVYGFSKLCMDEFVLSHSNDNI
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALGIMAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVAYIKNPYAFFQNHTQAHIEPTIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEEEECCHHHHHCCCCCCCCEEEE
DLDYTPLYDLESGIKDYLPHIRAIFKEHCA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRNNTLFSNNRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHH
HFKNLIGFKGEVVIADINNPLDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIHASSAGVYGNTKAPNVVGKNESPENVYGFSKLCMDEFVLSHSNDNI
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALGIMAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVAYIKNPYAFFQNHTQAHIEPTIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEEEECCHHHHHCCCCCCCCEEEE
DLDYTPLYDLESGIKDYLPHIRAIFKEHCA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA