Click here to switch to the map view.

The map label for this gene is fabL [H]

Identifier: 188527241

GI number: 188527241

Start: 425786

End: 426574

Strand: Reverse

Name: fabL [H]

Synonym: HPSH_02240

Alternate gene names: 188527241

Gene position: 426574-425786 (Counterclockwise)

Preceding gene: 188527242

Following gene: 188527240

Centisome position: 26.52

GC content: 43.22

Gene sequence:

>789_bases
ATGAACAATTCCAATCACATGAAAAATAAAACCCTAGTGATCAGCGGTGCGACTAGAGGGATTGGCAAGGCGATATTGTA
TCGCTTCGCTCAAAGCGGCGTGAATATCGCTTTCACTTACAATAAAAATGTTGAAGAAGCCAACAAAATTATAGAAGATG
TGGAGCAAAAATATTCCATTAAAGCCAAAGCCTACCCCCTTAATGTTTTAGAGCCTGAGCAATACACAGAGCTTTTTAAA
CAAATTGACGCTGATTTTGACAGAGTGGATTTTTTTATTTCTAACGCTATTATTTACGGGCGTTCTGTCGTGGGCGGATT
TGCGCCGTTTATGCGATTAAAACCTAAGGGGTTAAACAATATTTATACAGCCACTGTGTTAGCGTTTGTAGTGGGGGCTC
AAGAAGCGGCAAAACGCATGCAAAAAATAGGCGGCGGGGCGATCGTGAGCTTAAGCTCTACCGGGAATTTGGTCTATATG
CCTAATTACGCCGGGCATGGCAATTCTAAAAACGCCGTAGAAACCATGGTCAAATACGCTGCTGTTGATTTAGGCGAGTT
TAACATTAGAGTGAATGCGGTGAGTGGCGGGCCTATTGATACGGACGCTTTGAAAGCCTTCCCTGATTATGTGGAGATTA
AAGAAAAAGTAGAAGAGCAATCGCCCCTAAAACGCATGGGCAATCCTAACGATCTAGCCGGAGCGGCTTATTTTTTATGC
GATGAAACCCAAAGCGGTTGGCTTACAGGGCAAACGATCGTTGTAGATGGCGGGACTACTTTTAAATAA

Upstream 100 bases:

>100_bases
GCTTGATTGAAAACCCAAGCTACAGACTGCCTTTAGTGGTCCCAAGCAAGGAAACGATTAAACTTTTAGAAAAAACTTTA
CAACAATATGAGGTAATTGT

Downstream 100 bases:

>100_bases
AGATATTTTTTGCAAAACATTATCCACATCCACCAAAACAAAGAGTTGCAATTCATTAAAAAATGCTTGTTGTGCTATTT
TTTCGCCCCTTTGTGTGGGG

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNNSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPEQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK

Sequences:

>Translated_262_residues
MNNSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPEQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK
>Mature_262_residues
MNNSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPEQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=261, Percent_Identity=28.735632183908, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI126723750, Length=263, Percent_Identity=25.8555133079848, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=27.2030651340996, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787905, Length=260, Percent_Identity=32.6923076923077, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=25.1937984496124, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=27.4193548387097, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=28.0632411067194, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=26.2948207171315, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787545, Length=270, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=271, Percent_Identity=26.5682656826568, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=27.34375, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=25, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=23.828125, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=269, Percent_Identity=22.6765799256506, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=276, Percent_Identity=27.8985507246377, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=27.9850746268657, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=26.3565891472868, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=27.9527559055118, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=273, Percent_Identity=27.4725274725275, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=25.0950570342205, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=272, Percent_Identity=27.5735294117647, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=27.037037037037, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=26.0700389105058, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=25.0980392156863, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=278, Percent_Identity=26.6187050359712, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=279, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=278, Percent_Identity=27.3381294964029, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=274, Percent_Identity=26.2773722627737, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=27.3408239700375, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=26.8199233716475, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=287, Percent_Identity=28.9198606271777, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=221, Percent_Identity=28.0542986425339, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=28.957528957529, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=26.8482490272374, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644337, Length=117, Percent_Identity=39.3162393162393, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=23.7354085603113, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=25.6809338521401, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 28605; Mature: 28605

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCE
KAKAYPLNVLEPEQYTELFKQIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNN
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCH
IYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVETMVKYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHH
AVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
HHCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEE
DETQSGWLTGQTIVVDGGTTFK
CCCCCCEEECCEEEECCCCCCC
>Mature Secondary Structure
MNNSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCE
KAKAYPLNVLEPEQYTELFKQIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNN
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCH
IYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVETMVKYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHH
AVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
HHCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEE
DETQSGWLTGQTIVVDGGTTFK
CCCCCCEEECCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]