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The map label for this gene is lspA

Identifier: 188526880

GI number: 188526880

Start: 66115

End: 66588

Strand: Reverse

Name: lspA

Synonym: HPSH_00360

Alternate gene names: 188526880

Gene position: 66588-66115 (Counterclockwise)

Preceding gene: 188526881

Following gene: 188526879

Centisome position: 4.14

GC content: 36.29

Gene sequence:

>474_bases
GTGCTAAAAACCACCCAAAAAAGCCTGTTGATTTTTATAGTGGTTTTTTCCCTTATTTTTGGCACGGATCAAGCGATTAA
ATACGCTATTTTAGAGGGGTTTCGCTATGAAAGTTTGATTATAGATATTGTTTTAGTGTTCAATAAAGGCGTGGCGTTTT
CCTTGCTCAGTTTTTTAGAGGGGGGTTTGAAATACTTGCAAATCCTTTTGATTTTAGGGCTTTTTATCTTTTTAATGTGC
CAAAAGGAGCTTTTTAAAAACCATGCGATAGAGTTTGGCATGGTGTTTGGCGCTGGGGTTTCTAATGTTTTAGACCGGTT
TGTGCATGGGGGCGTGGTGGATTATGTGTATTATCATTATGGCTTTGATTTTGCCATTTTTAATTTCGCTGATGTCATGA
TAGATGTGGGCGTGGGCGTTTTATTGTTAAGACAATTCTTTTTTAAGCAAAAACAAAACAAAATTAAGGCATAA

Upstream 100 bases:

>100_bases
GCGGCACTGAAAACAAATTACGAATCCTCTTAGAAGCTAAAGATGAAAAACTTTTAGAATCCAAAATGCAAGAATTAAAA
GAGTTTTTTGAAGGGCATTT

Downstream 100 bases:

>100_bases
TTACCCTTTTTAAAATAAAAGGTCGCGTAGCTCAGTTGGTAGAGCACTACCTTGACATGGTAGTGGCCGCTGGTTCAAGT
CCAGTCGTGGCCACCATTAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MLKTTQKSLLIFIVVFSLIFGTDQAIKYAILEGFRYESLIIDIVLVFNKGVAFSLLSFLEGGLKYLQILLILGLFIFLMC
QKELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA

Sequences:

>Translated_157_residues
MLKTTQKSLLIFIVVFSLIFGTDQAIKYAILEGFRYESLIIDIVLVFNKGVAFSLLSFLEGGLKYLQILLILGLFIFLMC
QKELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA
>Mature_157_residues
MLKTTQKSLLIFIVVFSLIFGTDQAIKYAILEGFRYESLIIDIVLVFNKGVAFSLLSFLEGGLKYLQILLILGLFIFLMC
QKELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17907; Mature: 17907

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTTQKSLLIFIVVFSLIFGTDQAIKYAILEGFRYESLIIDIVLVFNKGVAFSLLSFLE
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHH
GGLKYLQILLILGLFIFLMCQKELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
GFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKTTQKSLLIFIVVFSLIFGTDQAIKYAILEGFRYESLIIDIVLVFNKGVAFSLLSFLE
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHH
GGLKYLQILLILGLFIFLMCQKELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
GFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]