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The map label for this gene is lip2 [H]

Identifier: 187930572

GI number: 187930572

Start: 3677042

End: 3677989

Strand: Reverse

Name: lip2 [H]

Synonym: Rpic_3507

Alternate gene names: 187930572

Gene position: 3677989-3677042 (Counterclockwise)

Preceding gene: 187930573

Following gene: 187930568

Centisome position: 93.29

GC content: 67.19

Gene sequence:

>948_bases
ATGGCCGTCGATCCGCAAATCCTGCAGTTCTACCAACGCCTTGCCGAACAGTTCGGCGCCCTGCCACTGCCCGAGGACGC
AGCCGCGCAGCGCGCGCGCTTCGAGGCGATTGCTGCGGTATCCGCCCGACCCGATCCCGACGGCGTTGAAGTTTCTGACT
TGAGCGTGCCGCTTGCGGGCCGCACGCTCGACGCCATCGTCTTTCGTCCGAAAGGCGTGGCAACGCCGCGTTTGCTGGTG
TGGTTTCACGGTGGCGGATGGGTGGTTGGCGCGCCGCGCACAACGCATCGCATGCTGGCCGCATTGATGGCGCAAGACAC
CGGCTGCGCCGTGATGAGCGTCGACTACCGCCTCGCGCCGGAGCATCCATTTCCCGTGCCGGCCGATGATGCCCGCGACG
CGCTCGCGTACCTGGCCGAGCAGCGCGTGCACCTCGGCTTCGATCCGGACTTCCTGGCTGTGGGTGGCGACAGCGCCGGC
GGCCATCTTGCGGTGCAGGCCGCGCAGGGTGCGCGCCCTGGCCTCGTCAATGCGCAGTTCCTGCTGTACCCCGTCACCAC
GCCGGCTTTTGGCAGCGAGAGCTACAACGCGTTTGCGCAAGGCCCCGGCCTCACGCGCGATGAAATGCGCTGGTACTGGG
AGAAATACATCGGTGCAGACGCCCTCGCCAAGCCCCTCGCCGAGCAAGACCCCCGCATCTTCCTGATGGCGCGCACGCCG
GCAACTACGCCGCCCGATACCGTCGTCATCGTGGCGGCGCACGACGTGCTGCGCGACGATGGCCTGCAATACGCCGACTA
CCTCGTGCAGCACGGCGCGCAGGTCATCACCATCGAAGCCTCGGGCATGACGCACGCCTTTGCGCGCATCCAGTTCGAGG
CCGAGCGTGCACGTGAATGGATGCGCCGCGCGGCGCACGCATTCGTCGGGATGATCAGCGGGGAATAA

Upstream 100 bases:

>100_bases
ATTCCGCTGCCGCTCGCGCCGTGCGGCTTCCTGACGTATCGGAAGGTCCAAGCCAGCGCGACGCGCTACACTCGGGCGGT
CGTCGCATCCCGCTTACGTC

Downstream 100 bases:

>100_bases
GTGAGGGGCAGGGCCTAACGCGTCGGCGTGCGGCGCTGGCGGAACGCGGCACGCACGCGGCGTGTGACAAACAGCGAGAG
ATAGTCCTGCACGCTGGCAT

Product: alpha/beta hydrolase fold-3 domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAVDPQILQFYQRLAEQFGALPLPEDAAAQRARFEAIAAVSARPDPDGVEVSDLSVPLAGRTLDAIVFRPKGVATPRLLV
WFHGGGWVVGAPRTTHRMLAALMAQDTGCAVMSVDYRLAPEHPFPVPADDARDALAYLAEQRVHLGFDPDFLAVGGDSAG
GHLAVQAAQGARPGLVNAQFLLYPVTTPAFGSESYNAFAQGPGLTRDEMRWYWEKYIGADALAKPLAEQDPRIFLMARTP
ATTPPDTVVIVAAHDVLRDDGLQYADYLVQHGAQVITIEASGMTHAFARIQFEAERAREWMRRAAHAFVGMISGE

Sequences:

>Translated_315_residues
MAVDPQILQFYQRLAEQFGALPLPEDAAAQRARFEAIAAVSARPDPDGVEVSDLSVPLAGRTLDAIVFRPKGVATPRLLV
WFHGGGWVVGAPRTTHRMLAALMAQDTGCAVMSVDYRLAPEHPFPVPADDARDALAYLAEQRVHLGFDPDFLAVGGDSAG
GHLAVQAAQGARPGLVNAQFLLYPVTTPAFGSESYNAFAQGPGLTRDEMRWYWEKYIGADALAKPLAEQDPRIFLMARTP
ATTPPDTVVIVAAHDVLRDDGLQYADYLVQHGAQVITIEASGMTHAFARIQFEAERAREWMRRAAHAFVGMISGE
>Mature_314_residues
AVDPQILQFYQRLAEQFGALPLPEDAAAQRARFEAIAAVSARPDPDGVEVSDLSVPLAGRTLDAIVFRPKGVATPRLLVW
FHGGGWVVGAPRTTHRMLAALMAQDTGCAVMSVDYRLAPEHPFPVPADDARDALAYLAEQRVHLGFDPDFLAVGGDSAGG
HLAVQAAQGARPGLVNAQFLLYPVTTPAFGSESYNAFAQGPGLTRDEMRWYWEKYIGADALAKPLAEQDPRIFLMARTPA
TTPPDTVVIVAAHDVLRDDGLQYADYLVQHGAQVITIEASGMTHAFARIQFEAERAREWMRRAAHAFVGMISGE

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=289, Percent_Identity=26.2975778546713, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI206597554, Length=268, Percent_Identity=26.1194029850746, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI68051721, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI157041239, Length=122, Percent_Identity=35.2459016393443, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786682, Length=269, Percent_Identity=26.0223048327138, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17567059, Length=249, Percent_Identity=30.1204819277108, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=113, Percent_Identity=38.9380530973451, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 34159; Mature: 34028

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDPQILQFYQRLAEQFGALPLPEDAAAQRARFEAIAAVSARPDPDGVEVSDLSVPLAG
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCCCC
RTLDAIVFRPKGVATPRLLVWFHGGGWVVGAPRTTHRMLAALMAQDTGCAVMSVDYRLAP
CCEEEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEEEECC
EHPFPVPADDARDALAYLAEQRVHLGFDPDFLAVGGDSAGGHLAVQAAQGARPGLVNAQF
CCCCCCCCCHHHHHHHHHHHCCEECCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEE
LLYPVTTPAFGSESYNAFAQGPGLTRDEMRWYWEKYIGADALAKPLAEQDPRIFLMARTP
EEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCC
ATTPPDTVVIVAAHDVLRDDGLQYADYLVQHGAQVITIEASGMTHAFARIQFEAERAREW
CCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCEEEEEEECCCEEEEHEEEEEHHHHHHH
MRRAAHAFVGMISGE
HHHHHHHHHHEECCC
>Mature Secondary Structure 
AVDPQILQFYQRLAEQFGALPLPEDAAAQRARFEAIAAVSARPDPDGVEVSDLSVPLAG
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCCCC
RTLDAIVFRPKGVATPRLLVWFHGGGWVVGAPRTTHRMLAALMAQDTGCAVMSVDYRLAP
CCEEEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEEEECC
EHPFPVPADDARDALAYLAEQRVHLGFDPDFLAVGGDSAGGHLAVQAAQGARPGLVNAQF
CCCCCCCCCHHHHHHHHHHHCCEECCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEE
LLYPVTTPAFGSESYNAFAQGPGLTRDEMRWYWEKYIGADALAKPLAEQDPRIFLMARTP
EEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCC
ATTPPDTVVIVAAHDVLRDDGLQYADYLVQHGAQVITIEASGMTHAFARIQFEAERAREW
CCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCEEEEEEECCCEEEEHEEEEEHHHHHHH
MRRAAHAFVGMISGE
HHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]