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The map label for this gene is ttdR [H]

Identifier: 187930542

GI number: 187930542

Start: 3633044

End: 3633955

Strand: Reverse

Name: ttdR [H]

Synonym: Rpic_3477

Alternate gene names: 187930542

Gene position: 3633955-3633044 (Counterclockwise)

Preceding gene: 187930548

Following gene: 187930541

Centisome position: 92.17

GC content: 65.9

Gene sequence:

>912_bases
ATGGACAAGCTCAAGCAGATCGAAGCGTTCATCGCCGTGGTGGAGCACGGCAGCATGGCCGCCGCCGCGCTCACGCAGGA
TGTGACGCCCGTCATGATCGGCCGCCGCATCAACGCGCTGGAAGCCCGCCTTGGCGTGAAGCTGCTGCATCGGTCCACCC
GCCGCATTGCGGTGACGGAGCAGGGCGCGGTCTTCATGGAACAGTGCAAGAAGGCGCTGGGCGAGCTGGACCGCGCGGAG
CTGCTCGTTGCCGAAGGCCGCCACAAGGCGACCGGGCACCTGATCGTCTCGGCGCCCGCAGCCTTCGGCCGCAAGCACGT
CGCGCCGCATGCGCCGGACTTTCTGCGTGCCAACCCCGACGTGCGCATCTCGTTCAACCTGACCGACCGCGTGGTCGACC
TCGTGCGCGAAGGCTACGACGTGGGCATCCGCATTGGCGGCGCGATCGATCCGAACTTCGTGGCGATTCGCCTGGCGTCG
AACAAGCGCGTCGTGTGCGGCACGCCCGCGTACTTCGCCAAGCATGGCGTGCCGCGCACGCTCGATGATCTCGCGCGCCA
CAACTGCCTAGCCTTTAACCTGCAGGGCGGGCAGCAGCGCGGCTGGTATTTCCAGCAGAACGGCAAGGCCGTCACCGTGA
AGGTGAACGGCAACCTCGACTGTAACGATGGTGAGTTGCTGCACCGCTGGATGGGTGAAGGCCTCGGTCTGGGCTGGCGC
TCAACGTGGGAGATTCAGCCGGAGCTGGAATCCGGCGCGCTGATGACGGTGCTGGACGACTACGCGCTGCCCGACTACGA
CATCCTCGCCGTGTACCCGCAGCAGCGGCCGGTGCCGGCAAAGATCCGGTTCTTTATCGAACACCTGAAGTCGGTGTACG
GGCAGGCAGGGTATTGGTCGCGAACGGGTTGA

Upstream 100 bases:

>100_bases
CATTTCTGTCATTCGTCACAGGTGATATGCGCCAGAAAGTCGCAATCCAGGTACGGAATGCTCACTAAAATGGTCAGACA
TTGCGAACTGGAATGATGGA

Downstream 100 bases:

>100_bases
GCGTGCGGAAACGGATGACGGTTCCTAAACTTGTCATCAGACGCATCGCGGGTGGCGCGCTCAATGCCGGAGACTGAAGA
TGCTACACAGAACTGCAGTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MDKLKQIEAFIAVVEHGSMAAAALTQDVTPVMIGRRINALEARLGVKLLHRSTRRIAVTEQGAVFMEQCKKALGELDRAE
LLVAEGRHKATGHLIVSAPAAFGRKHVAPHAPDFLRANPDVRISFNLTDRVVDLVREGYDVGIRIGGAIDPNFVAIRLAS
NKRVVCGTPAYFAKHGVPRTLDDLARHNCLAFNLQGGQQRGWYFQQNGKAVTVKVNGNLDCNDGELLHRWMGEGLGLGWR
STWEIQPELESGALMTVLDDYALPDYDILAVYPQQRPVPAKIRFFIEHLKSVYGQAGYWSRTG

Sequences:

>Translated_303_residues
MDKLKQIEAFIAVVEHGSMAAAALTQDVTPVMIGRRINALEARLGVKLLHRSTRRIAVTEQGAVFMEQCKKALGELDRAE
LLVAEGRHKATGHLIVSAPAAFGRKHVAPHAPDFLRANPDVRISFNLTDRVVDLVREGYDVGIRIGGAIDPNFVAIRLAS
NKRVVCGTPAYFAKHGVPRTLDDLARHNCLAFNLQGGQQRGWYFQQNGKAVTVKVNGNLDCNDGELLHRWMGEGLGLGWR
STWEIQPELESGALMTVLDDYALPDYDILAVYPQQRPVPAKIRFFIEHLKSVYGQAGYWSRTG
>Mature_303_residues
MDKLKQIEAFIAVVEHGSMAAAALTQDVTPVMIGRRINALEARLGVKLLHRSTRRIAVTEQGAVFMEQCKKALGELDRAE
LLVAEGRHKATGHLIVSAPAAFGRKHVAPHAPDFLRANPDVRISFNLTDRVVDLVREGYDVGIRIGGAIDPNFVAIRLAS
NKRVVCGTPAYFAKHGVPRTLDDLARHNCLAFNLQGGQQRGWYFQQNGKAVTVKVNGNLDCNDGELLHRWMGEGLGLGWR
STWEIQPELESGALMTVLDDYALPDYDILAVYPQQRPVPAKIRFFIEHLKSVYGQAGYWSRTG

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=285, Percent_Identity=34.7368421052632, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87081978, Length=292, Percent_Identity=34.2465753424658, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786401, Length=297, Percent_Identity=30.3030303030303, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787128, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789639, Length=297, Percent_Identity=26.2626262626263, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI145693193, Length=293, Percent_Identity=27.6450511945392, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787589, Length=293, Percent_Identity=25.5972696245734, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786448, Length=255, Percent_Identity=24.3137254901961, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788706, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789173, Length=259, Percent_Identity=25.0965250965251, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790011, Length=293, Percent_Identity=19.7952218430034, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI157672245, Length=161, Percent_Identity=29.1925465838509, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33546; Mature: 33546

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLKQIEAFIAVVEHGSMAAAALTQDVTPVMIGRRINALEARLGVKLLHRSTRRIAVTE
CCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEC
QGAVFMEQCKKALGELDRAELLVAEGRHKATGHLIVSAPAAFGRKHVAPHAPDFLRANPD
CCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCC
VRISFNLTDRVVDLVREGYDVGIRIGGAIDPNFVAIRLASNKRVVCGTPAYFAKHGVPRT
EEEEECCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHCCCCCC
LDDLARHNCLAFNLQGGQQRGWYFQQNGKAVTVKVNGNLDCNDGELLHRWMGEGLGLGWR
HHHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
STWEIQPELESGALMTVLDDYALPDYDILAVYPQQRPVPAKIRFFIEHLKSVYGQAGYWS
CEEEECCCCCCCEEEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
RTG
CCC
>Mature Secondary Structure
MDKLKQIEAFIAVVEHGSMAAAALTQDVTPVMIGRRINALEARLGVKLLHRSTRRIAVTE
CCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEC
QGAVFMEQCKKALGELDRAELLVAEGRHKATGHLIVSAPAAFGRKHVAPHAPDFLRANPD
CCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCC
VRISFNLTDRVVDLVREGYDVGIRIGGAIDPNFVAIRLASNKRVVCGTPAYFAKHGVPRT
EEEEECCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHCCCCCC
LDDLARHNCLAFNLQGGQQRGWYFQQNGKAVTVKVNGNLDCNDGELLHRWMGEGLGLGWR
HHHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
STWEIQPELESGALMTVLDDYALPDYDILAVYPQQRPVPAKIRFFIEHLKSVYGQAGYWS
CEEEECCCCCCCEEEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
RTG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]