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The map label for this gene is kefC [H]

Identifier: 187930445

GI number: 187930445

Start: 3541430

End: 3543370

Strand: Reverse

Name: kefC [H]

Synonym: Rpic_3379

Alternate gene names: 187930445

Gene position: 3543370-3541430 (Counterclockwise)

Preceding gene: 187930446

Following gene: 187930443

Centisome position: 89.87

GC content: 65.89

Gene sequence:

>1941_bases
ATGCAATCGCACGATCTGCTCGTCAATTTCGTCATCTACCTGGCTGCGGCTGTGGCAGCGGTGCCGCTGGCGCGTCGGCT
GGGGCTGGGCTCGGTGCTCGGCTATCTGCTGGCCGGGGTGATCGTCGGGCCGTGGGGCCTGCGGCTCATCACCAATGTGC
AGTCGATTCTGGATTTCTCTGAATTCGGCGTCGTACTGATGATGTTTGTGATTGGCCTGGAGCTGGAGCCGGCGCGGCTG
TGGTCGCTGCGGCGGAGCATCTTCGGCTACGGCGGGCTGCAGATTGTGGTGTGTGCGCTGGCCGTCGGGCTGGCGGTCAT
GGCGGTGGGCCATCCGTGGCGCTCAGCTGTGGTGGCGGGGCTGGGCCTGGCGCTGTCATCCACGGCGATTGCGCTGGCCA
CGCTTTCCGAGCGCAACCTCATGCGCACGCCCGCTGGCACGGCCAGCTTCGGCATTCTGCTGTTCCAGGACATTGCGGCC
ATCCCGATGATCGCGCTGCTGCCACTGTTGGCGACGGACGCAAGCGACGCGTCCGGCGGCCATAGCTGGGTGGCGGCGGC
CAAGGCAGTGGGCGTGGTGGCAGCCGTGATCTTTGGCGGACGCACCCTGCTGCGGCCCGTGCTGCGCGCAATTGCCCGCA
CCAACATGCGCGAGATGTTCACCTCGTTCTCGCTGCTGCTGGTGGTGGGCATTGCGCTGCTGATGCACGGCGTGGGCCTG
TCGATGGCGCTGGGCGCCTTCATTGCCGGTGTGCTGCTCGCCGATTCCGAATACCGTCACGCGCTCGAAACCGACATCGA
GCCGTTCAAGGGCCTGCTGCTCGGCCTGTTTTTCCTGGCCGTCGGCATGTCGATCGACTTTGGCGTGCTGATGCGCCAGC
CGTGGGCTGTGATCGGGCTGGTTGCGGTGTTCCTGGCGGTCAAGATTGGCGCGCTGCGCCTGCTCGCCAACCGCTTTGGC
ATTGCGCGCGGGCAGGCGTGGCTGTTTGCATTCCTGCTCTCGCAGGGTGGTGAATTTGCATTCGTGGTGTTCGGCCCCGG
CGTGGCGGGCAACGTGCTCGGTGCGGAGACGGCTGCTGCGCTCAACCTCGTGGTGGCGCTCTCGATGGCCGCGACGCCGT
TGCTGCTGCTCCTGCACGACAAGGTGCTGGTGCCGCGGTTCATGGATGGCAAGAAGCGCGCGCCCGACACGATCGAGCCG
CAGGAGAACGAAGTCATCATCGCGGGCTTCGGCCGATTTGGGCAGATTGTCGGTCGCATGCTCTATAGCCAGGGCTACAG
CGCCACCGTGCTCGATCACGACCCCGACCAGATCGACATGCTGCGCCGCTTCGGCTTCAAGGTCTTCTACGGCGATGCCA
CGCGCATGGACCTGCTGGAGACCGCCGGCGCCGACAAGGCCAGCATGATGGTTGTCGCCATCGACGACATGGAAACCAAC
CTGGAGGTGGTCGACCGCGTGCGCGAGCGCTTTCCCCACCTGAAGCTGTACGTGCGGGCGCGCAACGTGTCGCACGTGTA
CCAACTGCGCGACCGCGGCGTGGAAGTGATCGAGCGCGAGATGTTCGAGGGCTCGCTCATGCTTAGCCGCCGGGTGCTGG
AGGGCCTGGGCAAGGAGCCCTACGAAGCGCACCGCATCGCGCAGACGTTCCGCCGCCACACGCTCAATTCAATGGAGCAG
GTCTACCCGGTTTACCGCGATCAGAAGAAGCTCGTTTCCCTTGCACAGCAAGGGCGTGACGAACTGACCGAAATGTTCCA
GCGCGACCGCATGCAGCGCAAGCGCCTGCGCGAATCCGGCATGCCCTGGGGCGAGGGCGACGACCACAGCGACGTGGAAG
GCATGCAGCCCGACAGCGACCTGGCCAACGAAGGTGACGGTGGCGACGCCGACGCTCCGATTGATTGCCCCGCGCGCGCG
GGCATCCGACGCGACGGCTGA

Upstream 100 bases:

>100_bases
ACGCCCATATCGCGCAGGTCCGCGCCGCACTGCAGCCCTGGCTCCGGGCCGATGCCGACGCCAACTCCGTCGCCTGACGT
TTCCGATCTCTTCCCTGCCT

Downstream 100 bases:

>100_bases
CCCGCGCTGGTGATGAACCCCGTTCTAGGCGCAAGCAGCGTGAACAAACAAAAAGGAGCGCTTTTGGGCGCTCCTCGGGG
CAGACTGGCAGGATTGCGCG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MQSHDLLVNFVIYLAAAVAAVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQIVVCALAVGLAVMAVGHPWRSAVVAGLGLALSSTAIALATLSERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLATDASDASGGHSWVAAAKAVGVVAAVIFGGRTLLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHGVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPWAVIGLVAVFLAVKIGALRLLANRFG
IARGQAWLFAFLLSQGGEFAFVVFGPGVAGNVLGAETAAALNLVVALSMAATPLLLLLHDKVLVPRFMDGKKRAPDTIEP
QENEVIIAGFGRFGQIVGRMLYSQGYSATVLDHDPDQIDMLRRFGFKVFYGDATRMDLLETAGADKASMMVVAIDDMETN
LEVVDRVRERFPHLKLYVRARNVSHVYQLRDRGVEVIEREMFEGSLMLSRRVLEGLGKEPYEAHRIAQTFRRHTLNSMEQ
VYPVYRDQKKLVSLAQQGRDELTEMFQRDRMQRKRLRESGMPWGEGDDHSDVEGMQPDSDLANEGDGGDADAPIDCPARA
GIRRDG

Sequences:

>Translated_646_residues
MQSHDLLVNFVIYLAAAVAAVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQIVVCALAVGLAVMAVGHPWRSAVVAGLGLALSSTAIALATLSERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLATDASDASGGHSWVAAAKAVGVVAAVIFGGRTLLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHGVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPWAVIGLVAVFLAVKIGALRLLANRFG
IARGQAWLFAFLLSQGGEFAFVVFGPGVAGNVLGAETAAALNLVVALSMAATPLLLLLHDKVLVPRFMDGKKRAPDTIEP
QENEVIIAGFGRFGQIVGRMLYSQGYSATVLDHDPDQIDMLRRFGFKVFYGDATRMDLLETAGADKASMMVVAIDDMETN
LEVVDRVRERFPHLKLYVRARNVSHVYQLRDRGVEVIEREMFEGSLMLSRRVLEGLGKEPYEAHRIAQTFRRHTLNSMEQ
VYPVYRDQKKLVSLAQQGRDELTEMFQRDRMQRKRLRESGMPWGEGDDHSDVEGMQPDSDLANEGDGGDADAPIDCPARA
GIRRDG
>Mature_646_residues
MQSHDLLVNFVIYLAAAVAAVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQIVVCALAVGLAVMAVGHPWRSAVVAGLGLALSSTAIALATLSERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLATDASDASGGHSWVAAAKAVGVVAAVIFGGRTLLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHGVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPWAVIGLVAVFLAVKIGALRLLANRFG
IARGQAWLFAFLLSQGGEFAFVVFGPGVAGNVLGAETAAALNLVVALSMAATPLLLLLHDKVLVPRFMDGKKRAPDTIEP
QENEVIIAGFGRFGQIVGRMLYSQGYSATVLDHDPDQIDMLRRFGFKVFYGDATRMDLLETAGADKASMMVVAIDDMETN
LEVVDRVRERFPHLKLYVRARNVSHVYQLRDRGVEVIEREMFEGSLMLSRRVLEGLGKEPYEAHRIAQTFRRHTLNSMEQ
VYPVYRDQKKLVSLAQQGRDELTEMFQRDRMQRKRLRESGMPWGEGDDHSDVEGMQPDSDLANEGDGGDADAPIDCPARA
GIRRDG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=360, Percent_Identity=25, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786232, Length=620, Percent_Identity=51.2903225806452, Blast_Score=604, Evalue=1e-174,
Organism=Escherichia coli, GI1789749, Length=597, Percent_Identity=46.2311557788945, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786685, Length=539, Percent_Identity=29.6846011131725, Blast_Score=182, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 70204; Mature: 70204

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSHDLLVNFVIYLAAAVAAVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPARLWSLRRSIFGYGGLQIVVCALAVGLAVMAVGHPWRSAVVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGLALSSTAIALATLSERNLMRTPAGTASFGILLFQDIAAIPMIALLPLLATDASDASGG
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSWVAAAKAVGVVAAVIFGGRTLLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHGVGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPWAVIGL
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHH
VAVFLAVKIGALRLLANRFGIARGQAWLFAFLLSQGGEFAFVVFGPGVAGNVLGAETAAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LNLVVALSMAATPLLLLLHDKVLVPRFMDGKKRAPDTIEPQENEVIIAGFGRFGQIVGRM
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
LYSQGYSATVLDHDPDQIDMLRRFGFKVFYGDATRMDLLETAGADKASMMVVAIDDMETN
HHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCC
LEVVDRVRERFPHLKLYVRARNVSHVYQLRDRGVEVIEREMFEGSLMLSRRVLEGLGKEP
HHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YEAHRIAQTFRRHTLNSMEQVYPVYRDQKKLVSLAQQGRDELTEMFQRDRMQRKRLRESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
MPWGEGDDHSDVEGMQPDSDLANEGDGGDADAPIDCPARAGIRRDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQSHDLLVNFVIYLAAAVAAVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPARLWSLRRSIFGYGGLQIVVCALAVGLAVMAVGHPWRSAVVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGLALSSTAIALATLSERNLMRTPAGTASFGILLFQDIAAIPMIALLPLLATDASDASGG
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSWVAAAKAVGVVAAVIFGGRTLLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHGVGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPWAVIGL
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHH
VAVFLAVKIGALRLLANRFGIARGQAWLFAFLLSQGGEFAFVVFGPGVAGNVLGAETAAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LNLVVALSMAATPLLLLLHDKVLVPRFMDGKKRAPDTIEPQENEVIIAGFGRFGQIVGRM
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
LYSQGYSATVLDHDPDQIDMLRRFGFKVFYGDATRMDLLETAGADKASMMVVAIDDMETN
HHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCCC
LEVVDRVRERFPHLKLYVRARNVSHVYQLRDRGVEVIEREMFEGSLMLSRRVLEGLGKEP
HHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YEAHRIAQTFRRHTLNSMEQVYPVYRDQKKLVSLAQQGRDELTEMFQRDRMQRKRLRESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
MPWGEGDDHSDVEGMQPDSDLANEGDGGDADAPIDCPARAGIRRDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA