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The map label for this gene is recQ [H]

Identifier: 187930372

GI number: 187930372

Start: 3442811

End: 3444724

Strand: Reverse

Name: recQ [H]

Synonym: Rpic_3305

Alternate gene names: 187930372

Gene position: 3444724-3442811 (Counterclockwise)

Preceding gene: 187930373

Following gene: 187930370

Centisome position: 87.37

GC content: 67.82

Gene sequence:

>1914_bases
ATGTACGACTCTCCCGCCATAGACCACGCGCTGCAGGCGCTGCCCGAAGACACCGCCGCCGCGACGCATGCGGTGCTGCA
CGATGTGTTCGGCTACAGCGCCTTCCGCGGCCCGCAGGCGGAAATCGTCGCGCACGTCGCCGACGGCGGCGATTGTCTCG
TGCTGATGCCGACCGGCGGTGGCAAATCGCTCTGTTACCAGATACCGGCGCTCGTGCGGCACCGGCGCGGGCAGGGCGCC
GGCATTGTGGTTTCGCCGCTGATCGCGTTGATGCAGGACCAGGTGGCCGCGCTGGAAGAAGCCGGCGTGCGCGCCGCGTA
CCTCAACTCCGCGCTGACGGGCGCCGAGGCCGCCCAGGTCGAGCGAGATTTGGCGGCGGGCCGGCTGGATCTCGTCTACG
TGGCGCCCGAGCGGTTGATGACGCCGCGCTTCCTCGAGTTGCTTGAGCGATCGCGCATCGGCCTGTTCGCCATCGACGAA
GCGCACTGCGTGTCGCAATGGGGGCACGATTTCCGGCCCGAGTACATCCAGCTTTCCGTGCTGCACGAGCGTTTTCCGCA
CGTGCCGCGCATCGCGCTCACCGCCACGGCCGATGCGGTCACGCGGGACGAGATCATCGAACGGCTCGCGCTCACGGGTT
CCCGCGTCTTCCTCTCCAGCTTCGACCGCCCGAACATCCGCTACACCATCGTCGAGAAGGACAGCGCGCGGCAGCAGCTG
CTGCGCTTCATTCGCGCCGAGCACATGGACGGCGACACCTGCGACGCCGGCATCGTCTACTGCCTGTCGCGCAAGAAGGT
GGAAGAGACCGCGCAGTGGCTGGCCGAGCAGGGCATCCGCGCGCTGCCGTATCACGCCGGGATGGACTCCGACGTGCGCG
CACGCCATCAGGCCATCTTCCGCAAGGAGGAAGGCGTCGTGATGGTGGCGACCATCGCTTTCGGCATGGGGATCGACAAG
CCGGACGTCCGCTTCGTTGCCCACCTGGATCTGCCCAAGAGCCTGGAGGGCTACTATCAGGAGACTGGCCGTGCGGGCCG
TGACGGCATGCCCGCCAACGCCTGGATGGCTTACGGTCTGGCCGACGTGGTGCAGCAGCGCCGGATGATCGACGAGTCCG
ATGCGGACGATGTGCATAAGCGCGTCTCAACCGCCAAGCTCGAAGCGCTGCTCGGCCTGTGCGAAGCCGCAACCTGCCGC
CGTGTGGCGCTGCTCGCGTACTTCGGGGAAAGCAGCCAGCCCTGCGGCAACTGCGATACGTGCCTCACGCCGCCGCAAAC
CTGGGATGCCACACGCGAGGCACAGATGGCGCTGTCCTGCGCATACCGCGTCCAGCAAGCCAGCCGCGTGAGTTTTGGCG
CGGGCCAGCTCATCGACATCCTGCGCGGCAACGCAACCGAGCGCATCAAGCAGTGGCACCACGAAACGCTGTCCACCTTC
GGCATCGGCAGCGATCTGTCCGAAGCCGCTTGGCGCAGCGTATTCCGTCAGTTGGTTGCGCAGGGCTTGTTTGCGGTGGA
CCACGGCGGCCACGGTGCGCTGATCCTGACCGATGCCGCGCGCCCCGTGCTCAAGGGCGCGCAATCGGTGATCCTGCGCC
GTCAGGCCGAGAAGGTGCGCGGCGCGTCGTCATCGTCGACGAAGAAGGAGCGTCGCGCCGATCCGGCCGCCGAGCTTTCC
ACCGAGGCGCAGGTGCGCTGGCAGGCGTTGCGGGCCTGGCGGACGCAGGCCGCGCGCGAGCACAGCGTGCCGGCGTATGT
GATCTTCCACGACGCGACGCTTGCGCGCATTGCCGAGACCGATCCGGATTCGCGCGAGGCGCTCGGCGAGCTGCCGGGTA
TCGGCATGGCCAAGTTGGACCGCTACGGCCAGGCGCTGCTCGACGTACTGGAGAAGTGCCGCGAGCAAGCCTAG

Upstream 100 bases:

>100_bases
CCACAATCCGACTGTCCTGATTGACCACCCCTCGGCGGGGTTTGTCACAATAGCGGTTTCGCCCAGCCCGCGCGTGACAC
TGCGCGCACCCGCCGTCCCG

Downstream 100 bases:

>100_bases
GCGGACAGCGGCAATGGCCCCATCACGGCGGTGCTGCGCAGGTGGTCGCCCAGAAAATCGACAAACGCCCGCACCTTTGG
CAGCAGGTGCACACGCTGCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MYDSPAIDHALQALPEDTAAATHAVLHDVFGYSAFRGPQAEIVAHVADGGDCLVLMPTGGGKSLCYQIPALVRHRRGQGA
GIVVSPLIALMQDQVAALEEAGVRAAYLNSALTGAEAAQVERDLAAGRLDLVYVAPERLMTPRFLELLERSRIGLFAIDE
AHCVSQWGHDFRPEYIQLSVLHERFPHVPRIALTATADAVTRDEIIERLALTGSRVFLSSFDRPNIRYTIVEKDSARQQL
LRFIRAEHMDGDTCDAGIVYCLSRKKVEETAQWLAEQGIRALPYHAGMDSDVRARHQAIFRKEEGVVMVATIAFGMGIDK
PDVRFVAHLDLPKSLEGYYQETGRAGRDGMPANAWMAYGLADVVQQRRMIDESDADDVHKRVSTAKLEALLGLCEAATCR
RVALLAYFGESSQPCGNCDTCLTPPQTWDATREAQMALSCAYRVQQASRVSFGAGQLIDILRGNATERIKQWHHETLSTF
GIGSDLSEAAWRSVFRQLVAQGLFAVDHGGHGALILTDAARPVLKGAQSVILRRQAEKVRGASSSSTKKERRADPAAELS
TEAQVRWQALRAWRTQAAREHSVPAYVIFHDATLARIAETDPDSREALGELPGIGMAKLDRYGQALLDVLEKCREQA

Sequences:

>Translated_637_residues
MYDSPAIDHALQALPEDTAAATHAVLHDVFGYSAFRGPQAEIVAHVADGGDCLVLMPTGGGKSLCYQIPALVRHRRGQGA
GIVVSPLIALMQDQVAALEEAGVRAAYLNSALTGAEAAQVERDLAAGRLDLVYVAPERLMTPRFLELLERSRIGLFAIDE
AHCVSQWGHDFRPEYIQLSVLHERFPHVPRIALTATADAVTRDEIIERLALTGSRVFLSSFDRPNIRYTIVEKDSARQQL
LRFIRAEHMDGDTCDAGIVYCLSRKKVEETAQWLAEQGIRALPYHAGMDSDVRARHQAIFRKEEGVVMVATIAFGMGIDK
PDVRFVAHLDLPKSLEGYYQETGRAGRDGMPANAWMAYGLADVVQQRRMIDESDADDVHKRVSTAKLEALLGLCEAATCR
RVALLAYFGESSQPCGNCDTCLTPPQTWDATREAQMALSCAYRVQQASRVSFGAGQLIDILRGNATERIKQWHHETLSTF
GIGSDLSEAAWRSVFRQLVAQGLFAVDHGGHGALILTDAARPVLKGAQSVILRRQAEKVRGASSSSTKKERRADPAAELS
TEAQVRWQALRAWRTQAAREHSVPAYVIFHDATLARIAETDPDSREALGELPGIGMAKLDRYGQALLDVLEKCREQA
>Mature_637_residues
MYDSPAIDHALQALPEDTAAATHAVLHDVFGYSAFRGPQAEIVAHVADGGDCLVLMPTGGGKSLCYQIPALVRHRRGQGA
GIVVSPLIALMQDQVAALEEAGVRAAYLNSALTGAEAAQVERDLAAGRLDLVYVAPERLMTPRFLELLERSRIGLFAIDE
AHCVSQWGHDFRPEYIQLSVLHERFPHVPRIALTATADAVTRDEIIERLALTGSRVFLSSFDRPNIRYTIVEKDSARQQL
LRFIRAEHMDGDTCDAGIVYCLSRKKVEETAQWLAEQGIRALPYHAGMDSDVRARHQAIFRKEEGVVMVATIAFGMGIDK
PDVRFVAHLDLPKSLEGYYQETGRAGRDGMPANAWMAYGLADVVQQRRMIDESDADDVHKRVSTAKLEALLGLCEAATCR
RVALLAYFGESSQPCGNCDTCLTPPQTWDATREAQMALSCAYRVQQASRVSFGAGQLIDILRGNATERIKQWHHETLSTF
GIGSDLSEAAWRSVFRQLVAQGLFAVDHGGHGALILTDAARPVLKGAQSVILRRQAEKVRGASSSSTKKERRADPAAELS
TEAQVRWQALRAWRTQAAREHSVPAYVIFHDATLARIAETDPDSREALGELPGIGMAKLDRYGQALLDVLEKCREQA

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=655, Percent_Identity=34.9618320610687, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI14591902, Length=409, Percent_Identity=37.6528117359413, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI14591904, Length=409, Percent_Identity=37.6528117359413, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI148612816, Length=435, Percent_Identity=38.1609195402299, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI110735439, Length=588, Percent_Identity=32.6530612244898, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI169218196, Length=588, Percent_Identity=32.6530612244898, Blast_Score=267, Evalue=3e-71,
Organism=Homo sapiens, GI51242947, Length=405, Percent_Identity=38.2716049382716, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI51242943, Length=405, Percent_Identity=38.2716049382716, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI284005309, Length=366, Percent_Identity=36.0655737704918, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI48994977, Length=607, Percent_Identity=45.7990115321252, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1788930, Length=324, Percent_Identity=26.5432098765432, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=562, Percent_Identity=36.1209964412811, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71987997, Length=413, Percent_Identity=39.9515738498789, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71987993, Length=413, Percent_Identity=39.9515738498789, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI32564293, Length=675, Percent_Identity=32.1481481481481, Blast_Score=284, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17552866, Length=413, Percent_Identity=36.319612590799, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71987143, Length=339, Percent_Identity=24.7787610619469, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115533224, Length=350, Percent_Identity=24, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510307, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17510309, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=226, Percent_Identity=26.9911504424779, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=498, Percent_Identity=37.7510040160643, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6320224, Length=354, Percent_Identity=20.0564971751412, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=389, Percent_Identity=23.6503856041131, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324217, Length=355, Percent_Identity=23.6619718309859, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646066, Length=631, Percent_Identity=35.1822503961965, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI24664226, Length=460, Percent_Identity=36.7391304347826, Blast_Score=268, Evalue=1e-71,
Organism=Drosophila melanogaster, GI62472181, Length=457, Percent_Identity=37.199124726477, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24664230, Length=457, Percent_Identity=37.199124726477, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21358123, Length=367, Percent_Identity=35.6948228882834, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574962, Length=339, Percent_Identity=25.6637168141593, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18857967, Length=346, Percent_Identity=24.5664739884393, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 69967; Mature: 69967

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDSPAIDHALQALPEDTAAATHAVLHDVFGYSAFRGPQAEIVAHVADGGDCLVLMPTGG
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCEEEEEECCC
GKSLCYQIPALVRHRRGQGAGIVVSPLIALMQDQVAALEEAGVRAAYLNSALTGAEAAQV
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
ERDLAAGRLDLVYVAPERLMTPRFLELLERSRIGLFAIDEAHCVSQWGHDFRPEYIQLSV
HHHHHCCCEEEEEECHHHHCCHHHHHHHHHCCCCEEEECHHHHHHHCCCCCCCCHHHHHH
LHERFPHVPRIALTATADAVTRDEIIERLALTGSRVFLSSFDRPNIRYTIVEKDSARQQL
HHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCHHHHHH
LRFIRAEHMDGDTCDAGIVYCLSRKKVEETAQWLAEQGIRALPYHAGMDSDVRARHQAIF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RKEEGVVMVATIAFGMGIDKPDVRFVAHLDLPKSLEGYYQETGRAGRDGMPANAWMAYGL
HCCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ADVVQQRRMIDESDADDVHKRVSTAKLEALLGLCEAATCRRVALLAYFGESSQPCGNCDT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
CLTPPQTWDATREAQMALSCAYRVQQASRVSFGAGQLIDILRGNATERIKQWHHETLSTF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
GIGSDLSEAAWRSVFRQLVAQGLFAVDHGGHGALILTDAARPVLKGAQSVILRRQAEKVR
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
GASSSSTKKERRADPAAELSTEAQVRWQALRAWRTQAAREHSVPAYVIFHDATLARIAET
CCCCCCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCC
DPDSREALGELPGIGMAKLDRYGQALLDVLEKCREQA
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYDSPAIDHALQALPEDTAAATHAVLHDVFGYSAFRGPQAEIVAHVADGGDCLVLMPTGG
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCEEEEEECCC
GKSLCYQIPALVRHRRGQGAGIVVSPLIALMQDQVAALEEAGVRAAYLNSALTGAEAAQV
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
ERDLAAGRLDLVYVAPERLMTPRFLELLERSRIGLFAIDEAHCVSQWGHDFRPEYIQLSV
HHHHHCCCEEEEEECHHHHCCHHHHHHHHHCCCCEEEECHHHHHHHCCCCCCCCHHHHHH
LHERFPHVPRIALTATADAVTRDEIIERLALTGSRVFLSSFDRPNIRYTIVEKDSARQQL
HHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCHHHHHH
LRFIRAEHMDGDTCDAGIVYCLSRKKVEETAQWLAEQGIRALPYHAGMDSDVRARHQAIF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RKEEGVVMVATIAFGMGIDKPDVRFVAHLDLPKSLEGYYQETGRAGRDGMPANAWMAYGL
HCCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ADVVQQRRMIDESDADDVHKRVSTAKLEALLGLCEAATCRRVALLAYFGESSQPCGNCDT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
CLTPPQTWDATREAQMALSCAYRVQQASRVSFGAGQLIDILRGNATERIKQWHHETLSTF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
GIGSDLSEAAWRSVFRQLVAQGLFAVDHGGHGALILTDAARPVLKGAQSVILRRQAEKVR
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
GASSSSTKKERRADPAAELSTEAQVRWQALRAWRTQAAREHSVPAYVIFHDATLARIAET
CCCCCCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCC
DPDSREALGELPGIGMAKLDRYGQALLDVLEKCREQA
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]