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The map label for this gene is hisB

Identifier: 187930294

GI number: 187930294

Start: 3373612

End: 3374202

Strand: Reverse

Name: hisB

Synonym: Rpic_3227

Alternate gene names: 187930294

Gene position: 3374202-3373612 (Counterclockwise)

Preceding gene: 187930295

Following gene: 187930293

Centisome position: 85.58

GC content: 64.47

Gene sequence:

>591_bases
ATGAGCCGCCGTGCCGAGGTCACTCGTAACACCTCTGAAACGCAGATCCGCGTCGCCCTTGATTTGGACGGCACGGGCAA
GCAGACGCTGAACACCGGCGTCCCCTTCCTGGACCACATGCTCGACCAGATCGCCCGACATGGCATGGTCGACCTGGACG
TCTCGGCCACTGGCGACACCCATATCGACGATCACCACACCGTGGAAGACGTCGGCATCACGCTGGGCCAGGCCGTCGCC
AAGGCCATCGGCGACAAGAAGGGCATCGTGCGCTACGGCCACAGCTACGTACCGCTGGACGAGGCCCTGTCGCGCGTGGT
CATCGACTTCTCGGGCCGTCCGGGCCTGGAGTTCCACGTGCCGTTCACGCGCGCACGCGTGGGCAACTTTGACGTTGACC
TGTCCATCGAATTCTTCCGCGGGTTCGTCAACCATGCCGGCGTGACGCTGCATATCGACAACCTGCGCGGCGTCAACGCG
CACCACCAGATCGAAACCGTGTTCAAGGCCTTTGGCCGCGCGCTGCGCATGGCGGTAGAGATCGATCCGCGCGCTGCCGG
CACGATTCCGTCGACCAAGGGCGCCCTGTAA

Upstream 100 bases:

>100_bases
TGCACCCGTTGCTGGCCAACTGTCTGCGCGTGACGGTCAGCAATCCCGAAGAAAACGCGCAATTTATCGATGCCTTTGTC
GCATCGATGCAGGAAGCCCC

Downstream 100 bases:

>100_bases
ATCACTGCGTCGGCCTGGCCGCGCCTACCGACTCAGAAACCGGCCGCCGATCCGATGGATCTGACAAAAAGCTTCTTCTC
GCTGCTCGCGCTGATCAACC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVSATGDTHIDDHHTVEDVGITLGQAVA
KAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGNFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNA
HHQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL

Sequences:

>Translated_196_residues
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVSATGDTHIDDHHTVEDVGITLGQAVA
KAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGNFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNA
HHQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL
>Mature_195_residues
SRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVSATGDTHIDDHHTVEDVGITLGQAVAK
AIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGNFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAH
HQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50, Blast_Score=193, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_RALPJ (B2UEE9)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900781.1
- ProteinModelPortal:   B2UEE9
- SMR:   B2UEE9
- GeneID:   6287350
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_3227
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21403; Mature: 21271

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVSATGDT
CCCCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCC
HIDDHHTVEDVGITLGQAVAKAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCEEEC
PFTRARVGNFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQIETVFKAFGRALRMAVE
CHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEE
IDPRAAGTIPSTKGAL
ECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVSATGDT
CCCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCC
HIDDHHTVEDVGITLGQAVAKAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCEEEC
PFTRARVGNFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQIETVFKAFGRALRMAVE
CHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEE
IDPRAAGTIPSTKGAL
ECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA