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The map label for this gene is hisE

Identifier: 187930288

GI number: 187930288

Start: 3369845

End: 3370219

Strand: Reverse

Name: hisE

Synonym: Rpic_3221

Alternate gene names: 187930288

Gene position: 3370219-3369845 (Counterclockwise)

Preceding gene: 187930289

Following gene: 187930287

Centisome position: 85.48

GC content: 65.07

Gene sequence:

>375_bases
ATGAGTGACACCCTGCGCCGCCTGGGCGAGGTGCTCGAATCCCGCAAGCTCGCCAACGGCGGTGACCCGGAAAAGAGCTA
CATCGCGCGCCTGTTCAACAAGGGCGACGATGCCATCCTCAAAAAGATCGGCGAAGAGGCCACCGAGACCGTCATGGCCG
CCAAGGATGCTCGGGCCGCGGGCATGACCGACGAGGCGCGCAGCAAAGTCGTCTACGAAGTAGCCGACCTGTGGTTCCAC
ACCATGGTGCTGCTGTCGCACTTCGACCTCACGCCGGATGACGTCGTGGGCGAACTGGCGCGCCGCGAGGGGCTTTCCGG
TCTGGAAGAGAAGGCGCTGCGCAAGTTGCAGGCACGCGACGCAGCGGGGGACTGA

Upstream 100 bases:

>100_bases
CAGAAGTTCGAAGGCAATGTGGAAGACGGCGATTGGCACACCGTCGAGCCGGTGCTCAAGAACCCCGACGACATTTACGC
CGGCAAGCCCGGCCACAATC

Downstream 100 bases:

>100_bases
CTACGGTGACGGATCGTCGCAGGGAGGCAGTGTGGACAAATACGCAGCGGCAGTGGTGATGACGGACGACGCGGAGCGCC
TAGCCGGGCTGCGTCGCCTC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFNKGDDAILKKIGEEATETVMAAKDARAAGMTDEARSKVVYEVADLWFH
TMVLLSHFDLTPDDVVGELARREGLSGLEEKALRKLQARDAAGD

Sequences:

>Translated_124_residues
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFNKGDDAILKKIGEEATETVMAAKDARAAGMTDEARSKVVYEVADLWFH
TMVLLSHFDLTPDDVVGELARREGLSGLEEKALRKLQARDAAGD
>Mature_123_residues
SDTLRRLGEVLESRKLANGGDPEKSYIARLFNKGDDAILKKIGEEATETVMAAKDARAAGMTDEARSKVVYEVADLWFHT
MVLLSHFDLTPDDVVGELARREGLSGLEEKALRKLQARDAAGD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_RALPJ (B2UEE3)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900775.1
- ProteinModelPortal:   B2UEE3
- GeneID:   6286062
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_3221
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13635; Mature: 13503

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFNKGDDAILKKIGEEATETVMAAKDARAA
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GMTDEARSKVVYEVADLWFHTMVLLSHFDLTPDDVVGELARREGLSGLEEKALRKLQARD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
AAGD
CCCC
>Mature Secondary Structure 
SDTLRRLGEVLESRKLANGGDPEKSYIARLFNKGDDAILKKIGEEATETVMAAKDARAA
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GMTDEARSKVVYEVADLWFHTMVLLSHFDLTPDDVVGELARREGLSGLEEKALRKLQARD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
AAGD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA